Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formyltetrahydrofolate deformylase

Gene

PurU

Organism
Methylobacterium extorquens (Methylobacterium dichloromethanicum) (Protomonas extorquens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (PurU)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei230UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:PurUImported
Synonyms:purUUniRule annotation
OrganismiMethylobacterium extorquens (Methylobacterium dichloromethanicum) (Protomonas extorquens)Imported
Taxonomic identifieri408 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Structurei

3D structure databases

ProteinModelPortaliQ9X7F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 87ACTInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU. 1 hit.
InterProiView protein in InterPro
IPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR004810. PurU.
PANTHERiPTHR42706. PTHR42706. 1 hit.
PfamiView protein in Pfam
PF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiView protein in PROSITE
PS51671. ACT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X7F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKRYVLKI SCADRPGIVA AVSGALLERD CNIVEAKQFE DVIEKRFFMR
60 70 80 90 100
VVFSGINGQN SLREHQEAMT PLAQRFEMDW SIRDCETKRR VMILVSRFDH
110 120 130 140 150
CLVDILYRKR IGELPMDLTA VVTNHAAENY AHLDLCGAPL ISLPVTAETK
160 170 180 190 200
RAQEDKLLEL IERTGTEVVV LARYMQVLSA ELSARLSRRC INIHHSFLPG
210 220 230 240 250
FKGAKPYHQA YERGVKLMGA TAHYVTDDLD EGPIIEQDVE RISHSDSPED
260 270 280
LVRKGRDIER RVLARALRYH LDDRVLLNGH KTVVFPD
Length:287
Mass (Da):32,750
Last modified:November 1, 1999 - v1
Checksum:i4280864A02E1DE18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011316 Genomic DNA. Translation: CAB39401.1.
PIRiT51706.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9X7F7_METEX
AccessioniPrimary (citable) accession number: Q9X7F7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 5, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)