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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi: lipoprotein biosynthesis (signal peptide cleavage)

This protein is involved in the pathway lipoprotein biosynthesis (signal peptide cleavage), which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (signal peptide cleavage) and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311UniRule annotation
Active sitei160 – 1601UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

UniPathwayiUPA00665.

Protein family/group databases

MEROPSiA08.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:ML1199
ORF Names:MLCB458.14
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1199.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030CytoplasmicSequence analysisAdd
BLAST
Transmembranei31 – 5323HelicalUniRule annotationAdd
BLAST
Topological domaini54 – 8229ExtracellularSequence analysisAdd
BLAST
Transmembranei83 – 10523HelicalUniRule annotationAdd
BLAST
Topological domaini106 – 1116CytoplasmicSequence analysis
Transmembranei112 – 13423HelicalUniRule annotationAdd
BLAST
Topological domaini135 – 15521ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 17823HelicalUniRule annotationAdd
BLAST
Topological domaini179 – 20123CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Lipoprotein signal peptidasePRO_0000178797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1199.

Structurei

3D structure databases

ProteinModelPortaliQ9X7E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107ZIW. Bacteria.
COG0597. LUCA.
HOGENOMiHOG000096992.
KOiK03101.
OMAiVAKLEHH.
OrthoDBiPOG091H059F.

Family and domain databases

HAMAPiMF_00161. LspA. 1 hit.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PANTHERiPTHR33695:SF1. PTHR33695:SF1. 1 hit.
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X7E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGRVPDGPT GLAALVPSVE EAQAMLPPRR LRLLLSIAAV VLTLDIVTKV
60 70 80 90 100
LAVKFLLPGK SVSIIGDTVT WTLVRNSGAA FSMATGYTWV LTLIATGVVI
110 120 130 140 150
GIFWMGRRLV SSWWALGLGM ILGGAMGNLV DRFFRAPAPL RGHVVDFLSI
160 170 180 190 200
GWWPVFNVAD PSVVVGAILL VVLSIFGFDF DTVGRRKAEF DIAGQRKAEQ

R
Length:201
Mass (Da):21,691
Last modified:November 1, 1999 - v1
Checksum:iE4D7B58EE5C9B496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049478 Genomic DNA. Translation: CAB39579.1.
AL583921 Genomic DNA. Translation: CAC31580.1.
PIRiA87059.
RefSeqiNP_301873.1. NC_002677.1.
WP_010908194.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31580; CAC31580; CAC31580.
GeneIDi910324.
KEGGimle:ML1199.
PATRICi18054524. VBIMycLep78757_2202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049478 Genomic DNA. Translation: CAB39579.1.
AL583921 Genomic DNA. Translation: CAC31580.1.
PIRiA87059.
RefSeqiNP_301873.1. NC_002677.1.
WP_010908194.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9X7E7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1199.

Protein family/group databases

MEROPSiA08.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31580; CAC31580; CAC31580.
GeneIDi910324.
KEGGimle:ML1199.
PATRICi18054524. VBIMycLep78757_2202.

Organism-specific databases

LepromaiML1199.

Phylogenomic databases

eggNOGiENOG4107ZIW. Bacteria.
COG0597. LUCA.
HOGENOMiHOG000096992.
KOiK03101.
OMAiVAKLEHH.
OrthoDBiPOG091H059F.

Enzyme and pathway databases

UniPathwayiUPA00665.

Family and domain databases

HAMAPiMF_00161. LspA. 1 hit.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PANTHERiPTHR33695:SF1. PTHR33695:SF1. 1 hit.
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSPA_MYCLE
AccessioniPrimary (citable) accession number: Q9X7E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.