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Protein
Submitted name:

Putative type I fatty acid synthase

Gene

fas

Organism
Mycobacterium leprae
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative type I fatty acid synthaseImported
Gene namesi
Name:fasImported
OrganismiMycobacterium lepraeImported
Taxonomic identifieri1769 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Organism-specific databases

LepromaiML1191.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1191.

Structurei

3D structure databases

ProteinModelPortaliQ9X7E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4107RX2. Bacteria.
COG0304. LUCA.
COG0331. LUCA.
COG2030. LUCA.
COG4981. LUCA.
COG4982. LUCA.
HOGENOMiHOG000051526.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSiPR01483. FASYNTHASE.
SMARTiSM00827. PKS_AT. 1 hit.
SM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X7E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHEHDQVS ADRNGNSLHG SRALADRLKA GEPYVVAFGG QGSAWLETLE
60 70 80 90 100
ELVSSAGLEA DLATLVCEVE LLLEPVAKEL VVVRPIGFEP LQWVRALLAE
110 120 130 140 150
DLVPSDKHLT SAAVSVPGVL LTQIAVGRAL ARQGMDLIAT PPVGIVGHSQ
160 170 180 190 200
GVLAVEALKA GGARDAELLA MAQLIGAAGT LVARRRGISV LGDRPPMVSV
210 220 230 240 250
TNADPERIRR LLDEFAQDVR TVLPPVLSIR NGWRSVVITG TPEQLSRFER
260 270 280 290 300
YCRQISDKEE EDRRKKIRGG DIFAPVFDPV QVEIGFHTPH LADGIGIVGG
310 320 330 340 350
WAEKVGLDVT LARELTEAIL VRGVDWVREI TRVHGAGVRW IIDLGPGDIL
360 370 380 390 400
TRLTAPVIRG LGVGIVPVAN RGGQRTLFTV GAVPEVVRAW LSYAPTVVQL
410 420 430 440 450
PDGRIKLSTK FTRLTGRSPI LLAGMTPTTV DANIVAAAAN AGHWAELAGG
460 470 480 490 500
GQVTEEIFAN RVEQLSGLLE PGRTYQFNAL FLDPYLWKLQ VGGKRLVQKA
510 520 530 540 550
RQSGAAIDGV VISGGILDLE DAVELIEELG GIGISYVVFK PGTIEQIRSV
560 570 580 590 600
IRIATEMSTK PVIMHVEGGR AGGHHSWEDL DDLLLATYSE LRSHANITVC
610 620 630 640 650
VGGGIGTPEK AAEYLSGRWA QAYGFPLMPI DGILVGTAAM ATKEATTSPS
660 670 680 690 700
VKRMLVETQG TDQWIGSGKA QGGMASSRSQ LGADIHEIDN AASRCGRLLD
710 720 730 740 750
EVAGDAEAVA ERRDEIIAAM ANTAKPYFGD VSEMTYLQWL QRYVELTIGE
760 770 780 790 800
GNSTADTASP GSPWLADTWR DRFQKMLQRA ESRLHPSDFG LIKTIFTDPV
810 820 830 840 850
LLEKPNQAIA ALLKYYPDAE TVQLHPADAP FFVMLCQMLG KPVNFVPVID
860 870 880 890 900
KDVRRWWRSD SLWQAHDARY DADQVCIIPG IAAVAGITQM DEPVGELLDR
910 920 930 940 950
FEQAAIDEVL AGGAEPVVVM SRRLGRADVA GPLAVVLDAP DVLWAGRIAT
960 970 980 990 1000
NPVHRIADPN EWQVNGNLSA THSSTGAQLQ VKSEDQQVVL SVPVSNGWID
1010 1020 1030 1040 1050
IPFTLPTNTV DGGALLVSTE DATSAMRAVL AIVAGVDGPE LLSPVKDGTA
1060 1070 1080 1090 1100
IVTVDWNPER VADHTGVTAT FREPLAPSLA TVPDALVGAC WPAVFSAIGS
1110 1120 1130 1140 1150
AVTEAGVLVV EGLLNLLHLD HAVCVVGKLP TVPAQLTVTA TVSLAIDTDM
1160 1170 1180 1190 1200
GRVVPVSVTI RDTTGADGAV LATLEERFVI LGRTGTAELT GPVRAGGAIS
1210 1220 1230 1240 1250
ENATDTPRRR RRDVTLTAPI DMRPFAVVSG DHNPIHTDRT AALLAGLESP
1260 1270 1280 1290 1300
IVHGMWLSAA AQHVVMATDG QARPAARLIG WTARFLGMAH PGDKVDFRVD
1310 1320 1330 1340 1350
RIGIDQGAEI LEVSARISSG LVMSATARLA APKTVYAFPG QGIQHKGMGM
1360 1370 1380 1390 1400
DVRARSKAAR RVWDDADKFT RSGLGFSVLH VVRDNPTNIT ANGVHYHHPD
1410 1420 1430 1440 1450
GVLYLTQFTQ VAMATVAVAQ VAEMREQGAF VEGAIACGHS VGEYTALACV
1460 1470 1480 1490 1500
MGVYELEALL ETVFHRGSKM HDIVLRDELG RSNYRLAAIR PSQIGLPDDE
1510 1520 1530 1540 1550
VPAFVRGIAE STGEFLEIVN FNLRGSQYAI AGTVHGLEAL EAEVERRREL
1560 1570 1580 1590 1600
TGGRRSFILV PGIDVPFHSR VLRVGVAEFR RSLDRVLPQD QDPDWIIGRY
1610 1620 1630 1640 1650
IPNLVPRPFT LARDFIQEIR DLVPAEPLDD ILADYDTWRR ERPSEMARRV
1660 1670 1680 1690 1700
LIELLAWQFA SPVRWIETQD LLFTEEAAGG LGVERFVEIG VKSAPTVAGL
1710 1720 1730 1740 1750
ATDTLKLPEY SHNTVEVLNV ERDAAVLFAT DTDPELEPEP ENVSDASAAL
1760 1770 1780 1790 1800
PAESALALGT VAPAPVVPSG PRPEDISFGA ADATLALIAL SAKMRLDQIE
1810 1820 1830 1840 1850
EMDSIESITD GASSRRNQLL VDLGSELSLG AIDGVAEADL AGLRSQVTKL
1860 1870 1880 1890 1900
ARTYKPYGPV LSELINDQLR SALGPSGKRP GVIAERVKKI WELGDGWVKH
1910 1920 1930 1940 1950
VTVEIALGTR EGTSVRGGPL GNLNEGALAD VDSVDKAVDA AVASVAARHG
1960 1970 1980 1990 2000
VVVALPSAGS GGSATVDVAA LSEFTDQITG HDGVLASAAR LVLGQLGLDG
2010 2020 2030 2040 2050
PVTAAPATTD TGLIDLVTAE LSTDWPRLVA PVFDVKKAVV FDDRWASARE
2060 2070 2080 2090 2100
DLVRLWLNDE GEIEAQWSHL SERFEGAGHV VATQATWWQG KSLAAGRQIH
2110 2120 2130 2140 2150
ASLYGRIAAG AQNPDRGLYS SEIAVVTGAS KGSIAASVAA RLLDGGATVI
2160 2170 2180 2190 2200
ATTSKLDEER ITFYRALYRD HARYGAALWV VAANMASYSD IDALVEWIGN
2210 2220 2230 2240 2250
EQTESLGPQS IHIKDAQTPT LLFPFAAPRV IGDLSEAGAR SEIEMKVLLW
2260 2270 2280 2290 2300
AVQRLIVGLS KIGTERDVAS RLHVVLPGSP NRGMFGGDGA YGEAKSALDA
2310 2320 2330 2340 2350
VVSRWHAESS WAARVSLAHA LIGWTRGTGL MGHNDVIVSA VEEAGVTTYS
2360 2370 2380 2390 2400
TDEMAAMLLD LCNAESKVAA AGTPITVDLT GGLGEVDLDM AELAAKARED
2410 2420 2430 2440 2450
HAAQAAEDEA TEASEVAGTI AALPSPPRGY TPASPHWDDL DVDPADLVVI
2460 2470 2480 2490 2500
VGGAEIGPYG SSRTRFEMEV AGELSAAGVL ELVWTTGLIR WEDDPQPGWY
2510 2520 2530 2540 2550
DTESGELVDE SELVERYHDT VVQRCGIREF VDDGTIDPDH AYPLLVSVFL
2560 2570 2580 2590 2600
DKDFAFVVSS EADARAFVEF DPEHTVIRPV PDSSDWQVIR KAGTEIRVPR
2610 2620 2630 2640 2650
KMKLSRVVGG QIPTGFDPTV WGISPDMVSS IDRVAVWSIV ATVDAFLSAG
2660 2670 2680 2690 2700
FTPAEVMRYV HPSLVANTMG TGMGGGTSIQ RLYHSSLLGR NKPNDIFQEI
2710 2720 2730 2740 2750
LPNIVAAHVV QSYIGSYGSM IHPVAACATA AVSVEEGVDK IRLGKAELVV
2760 2770 2780 2790 2800
AGGIDDLTLE GIIGFGDMAA TADTAMMRGR GIHDSKFSRP NDRRRLGFVE
2810 2820 2830 2840 2850
AQGGGTILLA RGDLALKMGL PVFAVVAFAQ SFGDGVHTSI PAPGLGALGA
2860 2870 2880 2890 2900
GRGGKDSPLV QSLAKLGVSA DDIAVISKHD TSTLANDPNE TELHERLADA
2910 2920 2930 2940 2950
MGRSAGAPLF VVSQKSLTGH AKGGAAVFQM MGLCQMLRDG VIPPNRSLDC
2960 2970 2980 2990 3000
VDEELAGAAH FVWLRDTLRL GEKFPLKAGM LTSLGFGHVS GLVALVHPQA
3010 3020 3030 3040 3050
FIAALDPGQR DDYQRRANVR LLAGQRRLAS AIAGGAPMYE RPPDRRFDHH
3060 3070
VPEKLQEAAM LLNPAARLGD GDAYIG
Length:3,076
Mass (Da):328,361
Last modified:November 1, 1999 - v1
Checksum:iD88556730478E549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049478 Genomic DNA. Translation: CAB39571.1.
PIRiA87058.

Genome annotation databases

PATRICi18054494. VBIMycLep78757_2187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049478 Genomic DNA. Translation: CAB39571.1.
PIRiA87058.

3D structure databases

ProteinModelPortaliQ9X7E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1191.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi18054494. VBIMycLep78757_2187.

Organism-specific databases

LepromaiML1191.

Phylogenomic databases

eggNOGiENOG4107RX2. Bacteria.
COG0304. LUCA.
COG0331. LUCA.
COG2030. LUCA.
COG4981. LUCA.
COG4982. LUCA.
HOGENOMiHOG000051526.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSiPR01483. FASYNTHASE.
SMARTiSM00827. PKS_AT. 1 hit.
SM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae."
    Eiglmeier K., Honore N., Woods S.A., Caudron B., Cole S.T.
    Mol. Microbiol. 7:197-206(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. James K.D., Parkhill J., Barrell B.G., Rajandream M.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Seeger K.J., Harris D.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9X7E2_MYCLR
AccessioniPrimary (citable) accession number: Q9X7E2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.