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Q9X7C7 (TRPC_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:ML1271
ORF Names:MLCB1610.33
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134_B

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134_B

Sequence similarities

Belongs to the TrpC family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionindole-3-glycerol-phosphate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134_B
PRO_0000154233

Regions

Compositional bias32 – 398Poly-Ala HAMAP-Rule MF_00134_B

Sequences

Sequence LengthMass (Da)Tools
Q9X7C7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: DA5596D8D1D0DC59

FASTA27228,145
        10         20         30         40         50         60 
MCPATVLDSI LKGVRADVAA REACISLSEI KAAAAAAPAP LDAMAALREP GIGVIAEVKR 

        70         80         90        100        110        120 
ASPSVGSLAT IADPAKLAQA YEDGGARIIS VLTEERRFNG SLDDLDAVRA AVSVPVLRKD 

       130        140        150        160        170        180 
FVVQPYQIHE ARAHGADMLL LIVAALDQSA LMSMLDRTES LGMIALVEVR TEQEADRALK 

       190        200        210        220        230        240 
AGAKVIGVNA RDLMTLEVDR DCFSRIAPGL PSNVIRIAES GVRGPADLLA YAGAGADAVL 

       250        260        270 
VGEGLVKSGD PRAAVADLVT AGTHPSCPKP AR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL049913 Genomic DNA. Translation: CAB43179.1.
AL583921 Genomic DNA. Translation: CAC31652.1.
PIRT45256.
RefSeqNP_301916.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9X7C7.
ModBaseSearch...

Protein-protein interaction databases

STRING272631.ML1271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31652; CAC31652; CAC31652.
GeneID910382.
KEGGmle:ML1271.
PATRIC18054792. VBIMycLep78757_2335.

Organism-specific databases

LepromaML1271.
CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
HOGENOMHOG000230462.
KOK01609.
OMAYQAGGAR.
ProtClustDBPRK00278.

Enzyme and pathway databases

UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_B. IGPS_B.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_MYCLE
AccessionPrimary (citable) accession number: Q9X7C7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 29, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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