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Q9X7C5 (TRPE_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:ML1269
ORF Names:MLCB1610.31
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Anthranilate synthase component 1
PRO_0000154098

Sequences

Sequence LengthMass (Da)Tools
Q9X7C5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: A0D1E0920BA5E3D0

FASTA52957,031
        10         20         30         40         50         60 
MHAHLAATTS REDFRQLAVD HRVVPVTRKV LADSETPLSA YRKLAANRPS TFLLESAENG 

        70         80         90        100        110        120 
RSWSQWSFIG VGAPSALTIR DGEAVWLGTV PQDAPTGGDP LHVLQATLEL LATAAMPGLP 

       130        140        150        160        170        180 
PLSSGMVGFF AYDMVRRLER LPELALNDLQ LPDMLLLLAT DVAAVDHHEG TITLIANAVN 

       190        200        210        220        230        240 
WNGTDERVDQ AYDDAIARLD VMTAALGQPL PSTIATFSRP DPRRRAQCTI EEYGAIVDHL 

       250        260        270        280        290        300 
VDQIAAGEAF QVVPSQRFEV DTDVDPIDVY RMLRVTNPSP YMYLLHVPNS DGATGFSIVG 

       310        320        330        340        350        360 
SSPEALVTVK DGRVTTHPIA GTRWRGQTEE EDQLLEKELL ADEKERAEHL MLVDLGRNDL 

       370        380        390        400        410        420 
GRVCTPGTVR VEDYSHVERY SHVMHMVSTV TGLLGEGRTA LDAVTACFPA GTLSGAPKVR 

       430        440        450        460        470        480 
SMELIEEVEK TRRGLYGGVV GYLDFAGNAD FAIAIRTALM RDGIAYVQAG GGVVADSNGP 

       490        500        510        520 
YEYIEASNKA RAVLNAIAAA ETLTSLDFGV ALAPGRVAAR GEAGNQGRL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL049913 Genomic DNA. Translation: CAB43177.1.
AL583921 Genomic DNA. Translation: CAC31650.1.
PIRT45254.
RefSeqNP_301914.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9X7C5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029079; EBMYCP00000028685; EBMYCG00000029074.
GeneID910378.
GenomeReviewsGene locus ML1269 in contig AL450380_GR.
KEGGmle:ML1269.
NMPDRfig|272631.1.peg.786.
PATRIC18054788. VBIMycLep78757_2333.

Organism-specific databases

LepromaML1269.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015088.
HOGENOMHBG507440.
OMARTIYGRA.
ProtClustDBPRK13571.

Enzyme and pathway databases

BioCycMLEP272631:ML1269-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR005256. Anth_synth_I_PabB.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01657.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR00564. TrpE_most. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_MYCLE
AccessionPrimary (citable) accession number: Q9X7C5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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