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Q9X7C3 (HIS3_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19
Gene names
Name:hisI
Ordered Locus Names:ML1264
ORF Names:MLCB1610.27
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021

Subcellular location

Cytoplasm By similarity HAMAP MF_01021.

Sequence similarities

Belongs to the PRA-CH family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphoribosyl-AMP cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 115115Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021
PRO_0000136484

Sequences

Sequence LengthMass (Da)Tools
Q9X7C3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 623A2361F6F076E1

FASTA11512,582
        10         20         30         40         50         60 
MTLDPDIAVR LKRNAEGLFT AVVQERSSGD VLMVAWMDDQ ALARTLETRE ANYYSRSRAE 

        70         80         90        100        110 
QWIKGSTSGN TQHVHSVRLD CDGDTVLLTV DQVGGACHTG AHSCFDSAML LAPQD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL049913 Genomic DNA. Translation: CAB43173.1.
AL583921 Genomic DNA. Translation: CAC31645.1.
PIRT45252.
RefSeqNP_301912.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9X7C3.
SMRQ9X7C3. Positions 7-108.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029469; EBMYCP00000029075; EBMYCG00000029464.
GeneID910370.
GenomeReviewsGene locus ML1264 in contig AL450380_GR.
KEGGmle:ML1264.
NMPDRfig|272631.1.peg.784.
PATRIC18054774. VBIMycLep78757_2326.

Organism-specific databases

LepromaML1264.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017128.
HOGENOMHBG294308.
OMAGACHVGY.
ProtClustDBPRK00051.

Enzyme and pathway databases

BioCycMLEP272631:ML1264-MONOMER.

Family and domain databases

HAMAPMF_01021. HisI.
[Tree]
InterProIPR002496. PRib_AMP_CycHydrolase.
[Graphical view]
KOK01496.
PfamPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameHIS3_MYCLE
AccessionPrimary (citable) accession number: Q9X7C3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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