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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferase (EC:2.3.1.15)
Short name:
GPAT
Gene namesi
Name:plsB
Ordered Locus Names:ML1246
ORF Names:MLCB1610.07
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1246.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Glycerol-3-phosphate acyltransferasePRO_0000195224Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1246.

Structurei

3D structure databases

ProteinModelPortaliQ9X7B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi268 – 2736HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.Curated

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000045991.
KOiK00631.
OMAiEYLGEPH.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X7B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEPDVEISS VLTGEDTLVL ASMDTPAEIE LVMDWLCQQR NRNPDIKFDV
60 70 80 90 100
LKLPSRNLAP AALTALVEQL ESDEDRSVVP VRVFWMPPAE RSKLAKLAGL
110 120 130 140 150
LPGRDPYHPN RRQQRHILKT DARRALVIAG DSAKVSELRQ YWRDTTVGEN
160 170 180 190 200
ECDFAQFVTR RAILAMERAE SRILGPQYKS PRLVKPEILA STRFRAGLEK
210 220 230 240 250
ISGATVEEAG KMLDELATGW SRASVDLVSV LGRMLSRGFE PEIDYDEYQV
260 270 280 290 300
AAMRAALEAH PAVLLFSHRS YIDGAVVPVA MQENRLPPVH VFAGINLSFG
310 320 330 340 350
LMGPLLRRSG VIFIRRNIGD NPLYKYVLRE YVGYIVEKRF NLSWSIEGTR
360 370 380 390 400
SRTGKMLPPK LGLLTYVADA YLDGRSEDIL LQPVSISFDQ LHETAEYAAY
410 420 430 440 450
ARGGEKTPEG VAWLYSFIKA QGERNYGKIY VRFPEAVSMR QYLGAPHGAL
460 470 480 490 500
VQDQDAKRLA LQKMSFEVAW RILCATPVTA TALVSALLLT TRGVALTLDQ
510 520 530 540 550
LHHTLQESLD YLERKQTPVS KSALRLRSRE GVRAAVDALS SGHPITRVDS
560 570 580 590 600
GREPVWYITP GNEHAAAFYR NSVIHAFLET SIVELALAHA RHVEGDRMKV
610 620 630 640 650
FWAQAMRLRD LLKFDFYFAD SAAFRANIAE EIAWHQNWED RVSGDGDDID
660 670 680 690 700
AMLLTKRPLI SDAMLRVFFE AYDIVADVLR DAPADVGQKE LTELALGVGR
710 720 730 740 750
QYVAQGRVRS GESVSTLLFA TAYQVVVDQN LIAPAPDLAE RRMVFRRELR
760 770
DIRRDFDYVE QIARSRFIVR EFKSR
Length:775
Mass (Da):87,364
Last modified:November 1, 1999 - v1
Checksum:i03DD77C778293CDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049913 Genomic DNA. Translation: CAB43153.1.
AL583921 Genomic DNA. Translation: CAC31627.1.
PIRiT45238.
RefSeqiNP_301900.1. NC_002677.1.
WP_010908221.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31627; CAC31627; CAC31627.
GeneIDi910352.
KEGGimle:ML1246.
PATRICi18054718. VBIMycLep78757_2298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049913 Genomic DNA. Translation: CAB43153.1.
AL583921 Genomic DNA. Translation: CAC31627.1.
PIRiT45238.
RefSeqiNP_301900.1. NC_002677.1.
WP_010908221.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9X7B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31627; CAC31627; CAC31627.
GeneIDi910352.
KEGGimle:ML1246.
PATRICi18054718. VBIMycLep78757_2298.

Organism-specific databases

LepromaiML1246.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000045991.
KOiK00631.
OMAiEYLGEPH.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_MYCLE
AccessioniPrimary (citable) accession number: Q9X7B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.