Q9X795 (COAA_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	ML1954
ORF Names:	MLCB1222.23

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_0000194438
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9X795 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: FBAEF9DD3F397871	FASTA	312	35,492
	10 20 30 40 50 60 MPRLSEPSPY VEFDRKQWRA LRMSTPLALT EEELIGLRGL GEQIDLLEVE EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATAEFLGE PQQNPGRPVP FIIGVAGSVA VGKSTTARVL QALLARWDHH 130 140 150 160 170 180 TRVDLVTTDG FLYPNAELGR RNLMHRKGFP ESYNRRALMR FVTSVKSGAD YACAPVYSHL 190 200 210 220 230 240 RYDTIPGAKH VVRHPDILIL EGLNVLQTGP TLMVSDLFDF SLYVDARIQD IEQWYVSRFL 250 260 270 280 290 300 AMRGTAFADP ESHFHHYSAL TDSKAIIAAR EIWRSINRPN LVENILPTRP RATLVLRKDA 310 DHSINRLRLR KL

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL049491 Genomic DNA. Translation: CAB39829.1. AL583923 Genomic DNA. Translation: CAC30909.1.
PIR	E87153.
RefSeq	NP_302319.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q9X795.
SMR	Q9X795. Positions 5-312.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029107; EBMYCP00000028713; EBMYCG00000029102.
GeneID	909435.
GenomeReviews	Gene locus ML1954 in contig AL450380_GR.
KEGG	mle:ML1954.
NMPDR	fig|272631.1.peg.1191.
PATRIC	18057558. VBIMycLep78757_3703.
Organism-specific databases
Leproma	ML1954.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016369.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1954-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_MYCLE

Accession

Primary (citable) accession number: Q9X795

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program