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Protein

Pantothenate kinase

Gene

coaA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase (EC:2.7.1.33)
Alternative name(s):
Pantothenic acid kinase
Gene namesi
Name:coaA
Ordered Locus Names:ML1954
ORF Names:MLCB1222.23
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1954.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001944381 – 312Pantothenate kinaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1954.

Structurei

3D structure databases

ProteinModelPortaliQ9X795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.
OrthoDBiPOG091H073G.

Family and domain databases

CDDicd02025. PanK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLSEPSPY VEFDRKQWRA LRMSTPLALT EEELIGLRGL GEQIDLLEVE
60 70 80 90 100
EVYLPLARLI HLQVAARQRL FAATAEFLGE PQQNPGRPVP FIIGVAGSVA
110 120 130 140 150
VGKSTTARVL QALLARWDHH TRVDLVTTDG FLYPNAELGR RNLMHRKGFP
160 170 180 190 200
ESYNRRALMR FVTSVKSGAD YACAPVYSHL RYDTIPGAKH VVRHPDILIL
210 220 230 240 250
EGLNVLQTGP TLMVSDLFDF SLYVDARIQD IEQWYVSRFL AMRGTAFADP
260 270 280 290 300
ESHFHHYSAL TDSKAIIAAR EIWRSINRPN LVENILPTRP RATLVLRKDA
310
DHSINRLRLR KL
Length:312
Mass (Da):35,492
Last modified:November 1, 1999 - v1
Checksum:iFBAEF9DD3F397871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049491 Genomic DNA. Translation: CAB39829.1.
AL583923 Genomic DNA. Translation: CAC30909.1.
PIRiE87153.
RefSeqiNP_302319.1. NC_002677.1.
WP_010908640.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30909; CAC30909; CAC30909.
GeneIDi909435.
KEGGimle:ML1954.
PATRICi18057558. VBIMycLep78757_3703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049491 Genomic DNA. Translation: CAB39829.1.
AL583923 Genomic DNA. Translation: CAC30909.1.
PIRiE87153.
RefSeqiNP_302319.1. NC_002677.1.
WP_010908640.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9X795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30909; CAC30909; CAC30909.
GeneIDi909435.
KEGGimle:ML1954.
PATRICi18057558. VBIMycLep78757_3703.

Organism-specific databases

LepromaiML1954.

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.
OrthoDBiPOG091H073G.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

CDDicd02025. PanK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAA_MYCLE
AccessioniPrimary (citable) accession number: Q9X795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.