Q9X784 (EX7S_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease 7 small subunit
EC=3.1.11.6

Alternative name(s):
Exodeoxyribonuclease VII small subunit
Short name=Exonuclease VII small subunit

Gene names

Name:	xseB
Ordered Locus Names:	ML1941
ORF Names:	MLCB1222.09

Organism

Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP]

Taxonomic identifier

272631 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00337
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00337
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00337.
Sequence similarities	Belongs to the XseB family.
Sequence caution	The sequence CAB39815.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC30896.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular_function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 78	78	Exodeoxyribonuclease 7 small subunit HAMAP-Rule MF_00337		PRO_0000206973

Sequences

	Sequence		Length	Mass (Da)
	Q9X784 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 610D601F32D0725E	FASTA	78	8,865
	10 20 30 40 50 60 MRSTTPINTT PINQLGYEAC RDELIEVVRL LEQGGLNLDM SLKLWERGEQ LAKRCEEHLD 70 GARQRVADVL SARQVEEA

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL049491 Genomic DNA. Translation: CAB39815.1. Different initiation. AL583923 Genomic DNA. Translation: CAC30896.1. Different initiation.
PIR	H87151.
RefSeq	NP_302309.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q9X784.
ModBase	Search...
Protein-protein interaction databases
STRING	272631.ML1941.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC30896; CAC30896; CAC30896.
GeneID	910018.
KEGG	mle:ML1941.
PATRIC	18057516. VBIMycLep78757_3682.
Organism-specific databases
Leproma	ML1941.
CMR	Search...
Phylogenomic databases
eggNOG	COG1722.
HOGENOM	HOG000228798.
KO	K03602.
ProtClustDB	PRK00977.
Family and domain databases
Gene3D	1.10.287.1040. 1 hit.
HAMAP	MF_00337. Exonuc_7_S.
InterPro	IPR003761. Exonuc_VII_S. [Graphical view]
Pfam	PF02609. Exonuc_VII_S. 1 hit. [Graphical view]
PIRSF	PIRSF006488. Exonuc_VII_S. 1 hit.
ProDom	PD028235. Exonuc_VII_S. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF116842. SSF116842. 1 hit.
TIGRFAMs	TIGR01280. xseB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7S_MYCLE

Accession

Primary (citable) accession number: Q9X784

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program