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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:ML1940
ORF Names:MLCB1222.08
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1940.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Exodeoxyribonuclease 7 large subunitPRO_0000197859Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1940.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229264.
KOiK03601.
OMAiENAQVRC.
OrthoDBiPOG091H02EK.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAVPTDSV DSKASSQVNS AENPFPVRAV ALRIAGWIDK LGTVWVEGQL
60 70 80 90 100
AQITMRPNAK TVFMVLRDPA ADISLIVTCS RDFVLRAPVK LAEGIQVVVC
110 120 130 140 150
GKPSFYIGRG TFSLRLSDIR AVGIGELLVR IDRLRRLLDS EGLFDPRLKR
160 170 180 190 200
PIPFLPNMIG IITGRASAAE RDVTTVASAR WPAARFAIRN TAVQGPNAVS
210 220 230 240 250
QIVEALRELD RNVDVEVIVV ARGGGSVEDL LTFSDETLCR AIAACRTPVI
260 270 280 290 300
SAVGHEPDNP LCDLVADLRA ATPTDAAKKV VPDAAVEQRL IEDLQRRSAQ
310 320 330 340 350
ALRNWVSREQ RTLVQLRSRP VLAEPLRTLT TRSEEIHRAQ SAIRREIIRL
360 370 380 390 400
VTTETERVGH LATQLATLGP AATLARGYAI VQALEDGTQT VTAAVLRSVD
410 420
DAPTGTRLRV RVSDGAIVAV SEGRADGP
Length:428
Mass (Da):46,322
Last modified:November 1, 1999 - v1
Checksum:i575791F23EDB56C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049491 Genomic DNA. Translation: CAB39814.1.
AL583923 Genomic DNA. Translation: CAC30895.1.
PIRiG87151.
RefSeqiNP_302308.1. NC_002677.1.
WP_010908629.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30895; CAC30895; CAC30895.
GeneIDi910082.
KEGGimle:ML1940.
PATRICi18057514. VBIMycLep78757_3681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049491 Genomic DNA. Translation: CAB39814.1.
AL583923 Genomic DNA. Translation: CAC30895.1.
PIRiG87151.
RefSeqiNP_302308.1. NC_002677.1.
WP_010908629.1. NC_002677.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30895; CAC30895; CAC30895.
GeneIDi910082.
KEGGimle:ML1940.
PATRICi18057514. VBIMycLep78757_3681.

Organism-specific databases

LepromaiML1940.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229264.
KOiK03601.
OMAiENAQVRC.
OrthoDBiPOG091H02EK.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_MYCLE
AccessioniPrimary (citable) accession number: Q9X783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.