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Q9X721

- Q9X721_CLOHI

UniProt

Q9X721 - Q9X721_CLOHI

Protein
Submitted name:

Collagenase

Gene

colG

Organism
Clostridium histolyticum
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi523 – 5231Zinc; via tele nitrogen
    Metal bindingi527 – 5271Zinc; via tele nitrogen
    Metal bindingi555 – 5551Zinc
    Metal bindingi795 – 7951Calcium 1Imported
    Metal bindingi796 – 7961Calcium 1; via carbonyl oxygenImported
    Metal bindingi823 – 8231Calcium 1Imported
    Metal bindingi825 – 8251Calcium 1Imported
    Metal bindingi864 – 8641Calcium 1Imported
    Metal bindingi1009 – 10091Calcium 2Imported
    Metal bindingi1011 – 10111Calcium 2Imported
    Metal bindingi1011 – 10111Calcium 3Imported
    Metal bindingi1013 – 10131Calcium 3Imported
    Metal bindingi1014 – 10141Calcium 3Imported
    Metal bindingi1032 – 10321Calcium 2; via carbonyl oxygenImported
    Metal bindingi1037 – 10371Calcium 2Imported
    Metal bindingi1037 – 10371Calcium 3Imported
    Metal bindingi1039 – 10391Calcium 3; via carbonyl oxygenImported
    Metal bindingi1040 – 10401Calcium 2Imported
    Metal bindingi1040 – 10401Calcium 3Imported

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported, ZincImported

    Protein family/group databases

    MEROPSiM09.002.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CollagenaseImported
    Gene namesi
    Name:colGImported
    OrganismiClostridium histolyticumImported
    Taxonomic identifieri1498 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: InterPro

    Pathology & Biotechi

    Protein family/group databases

    Allergomei5989. Clo hi Collagenase.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Y3UX-ray2.55A119-880[»]
    2Y50X-ray2.80A119-880[»]
    2Y6IX-ray3.25A119-880[»]
    2Y72X-ray1.18A/B799-880[»]
    3JQUX-ray1.40A/B797-881[»]
    4AQOX-ray0.99A792-880[»]
    4AREX-ray2.19A119-790[»]
    4HPKX-ray1.35A1006-1118[»]
    B1002-1118[»]
    4JRWX-ray1.60A/B797-881[»]
    ProteinModelPortaliQ9X721.
    SMRiQ9X721. Positions 1005-1118.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X721.

    Family & Domainsi

    Keywords - Domaini

    CollagenImported

    Family and domain databases

    Gene3Di2.60.40.670. 1 hit.
    InterProiIPR007280. Peptidase_C_arc/bac.
    IPR013661. Peptidase_M9_N_dom.
    IPR002169. Peptidase_M9A/M9B.
    IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    [Graphical view]
    PfamiPF01752. Peptidase_M9. 1 hit.
    PF08453. Peptidase_M9_N. 1 hit.
    PF00801. PKD. 1 hit.
    PF04151. PPC. 1 hit.
    [Graphical view]
    PRINTSiPR00931. MICOLLPTASE.
    SMARTiSM00089. PKD. 1 hit.
    [Graphical view]
    SUPFAMiSSF49299. SSF49299. 1 hit.
    PROSITEiPS50093. PKD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X721-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNILKILM DSYSKESKIQ TVRRVTSVSL LAVYLTMNTS SLVLAKPIEN     50
    TNDTSIKNVE KLRNAPNEEN SKKVEDSKND KVEHVKNIEE AKVEQVAPEV 100
    KSKSTLRSAS IANTNSEKYD FEYLNGLSYT ELTNLIKNIK WNQINGLFNY 150
    STGSQKFFGD KNRVQAIINA LQESGRTYTA NDMKGIETFT EVLRAGFYLG 200
    YYNDGLSYLN DRNFQDKCIP AMIAIQKNPN FKLGTAVQDE VITSLGKLIG 250
    NASANAEVVN NCVPVLKQFR ENLNQYAPDY VKGTAVNELI KGIEFDFSGA 300
    AYEKDVKTMP WYGKIDPFIN ELKALGLYGN ITSATEWASD VGIYYLSKFG 350
    LYSTNRNDIV QSLEKAVDMY KYGKIAFVAM ERITWDYDGI GSNGKKVDHD 400
    KFLDDAEKHY LPKTYTFDNG TFIIRAGDKV SEEKIKRLYW ASREVKSQFH 450
    RVVGNDKALE VGNADDVLTM KIFNSPEEYK FNTNINGVST DNGGLYIEPR 500
    GTFYTYERTP QQSIFSLEEL FRHEYTHYLQ ARYLVDGLWG QGPFYEKNRL 550
    TWFDEGTAEF FAGSTRTSGV LPRKSILGYL AKDKVDHRYS LKKTLNSGYD 600
    DSDWMFYNYG FAVAHYLYEK DMPTFIKMNK AILNTDVKSY DEIIKKLSDD 650
    ANKNTEYQNH IQELADKYQG AGIPLVSDDY LKDHGYKKAS EVYSEISKAA 700
    SLTNTSVTAE KSQYFNTFTL RGTYTGETSK GEFKDWDEMS KKLDGTLESL 750
    AKNSWSGYKT LTAYFTNYRV TSDNKVQYDV VFHGVLTDNA DISNNKAPIA 800
    KVTGPSTGAV GRNIEFSGKD SKDEDGKIVS YDWDFGDGAT SRGKNSVHAY 850
    KKAGTYNVTL KVTDDKGATA TESFTIEIKN EDTTTPITKE MEPNDDIKEA 900
    NGPIVEGVTV KGDLNGSDDA DTFYFDVKED GDVTIELPYS GSSNFTWLVY 950
    KEGDDQNHIA SGIDKNNSKV GTFKSTKGRH YVFIYKHDSA SNISYSLNIK 1000
    GLGNEKLKEK ENNDSSDKAT VIPNFNTTMQ GSLLGDDSRD YYSFEVKEEG 1050
    EVNIELDKKD EFGVTWTLHP ESNINDRITY GQVDGNKVSN KVKLRPGKYY 1100
    LLVYKYSGSG NYELRVNK 1118
    Length:1,118
    Mass (Da):126,242
    Last modified:November 1, 1999 - v1
    Checksum:i770CF3F60E4D4FD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87215 Genomic DNA. Translation: BAA77453.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87215 Genomic DNA. Translation: BAA77453.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Y3U X-ray 2.55 A 119-880 [» ]
    2Y50 X-ray 2.80 A 119-880 [» ]
    2Y6I X-ray 3.25 A 119-880 [» ]
    2Y72 X-ray 1.18 A/B 799-880 [» ]
    3JQU X-ray 1.40 A/B 797-881 [» ]
    4AQO X-ray 0.99 A 792-880 [» ]
    4ARE X-ray 2.19 A 119-790 [» ]
    4HPK X-ray 1.35 A 1006-1118 [» ]
    B 1002-1118 [» ]
    4JRW X-ray 1.60 A/B 797-881 [» ]
    ProteinModelPortali Q9X721.
    SMRi Q9X721. Positions 1005-1118.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 5989. Clo hi Collagenase.
    MEROPSi M09.002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9X721.

    Family and domain databases

    Gene3Di 2.60.40.670. 1 hit.
    InterProi IPR007280. Peptidase_C_arc/bac.
    IPR013661. Peptidase_M9_N_dom.
    IPR002169. Peptidase_M9A/M9B.
    IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    [Graphical view ]
    Pfami PF01752. Peptidase_M9. 1 hit.
    PF08453. Peptidase_M9_N. 1 hit.
    PF00801. PKD. 1 hit.
    PF04151. PPC. 1 hit.
    [Graphical view ]
    PRINTSi PR00931. MICOLLPTASE.
    SMARTi SM00089. PKD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49299. SSF49299. 1 hit.
    PROSITEi PS50093. PKD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene duplication and multiplicity of collagenases in Clostridium histolyticum."
      Matsushita O., Jung C.-M., Katayama S., Minami J., Takahashi Y., Okabe A.
      J. Bacteriol. 181:923-933(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JCM 1403Imported.
    2. "Crystal structure of Clostridium histolyticum colG collagenase polycystic kidney disease domain at 1.4 Angstrom resolution."
      Sakon J, Philominathan S.T.L., Matsushita O., Gunn S.
      Submitted (SEP-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 797-881.
    3. "Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis."
      Eckhard U., Schonauer E., Nuss D., Brandstetter H.
      Nat. Struct. Mol. Biol. 18:1109-1114(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.18 ANGSTROMS) OF 799-880 IN COMPLEX WITH ZINC.
    4. "Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum."
      Bauer R., Wilson J.J., Philominathan S.T., Davis D., Matsushita O., Sakon J.
      J. Bacteriol. 195:318-327(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 1006-1118 AND 1002-1118 IN COMPLEX WITH CALCIUM.
    5. "Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T."
      Eckhard U., Schonauer E., Brandstetter H.
      J. Biol. Chem. 288:20184-20194(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (0.99 ANGSTROMS) OF 792-880 IN COMPLEX WITH CALCIUM AND ZINC.
    6. "Crystal structure of Clostridium histolyticum colg collagenase PKD domain 2 at 1.6 Angstrom resolution."
      Sakon J., Philominathan S.T.L., Gann S., Bauer R., Matsushita O.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 797-881.

    Entry informationi

    Entry nameiQ9X721_CLOHI
    AccessioniPrimary (citable) accession number: Q9X721
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3