SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9X721

- Q9X721_CLOHI

UniProt

Q9X721 - Q9X721_CLOHI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Collagenase
Gene
colG
Organism
Clostridium histolyticum
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi523 – 5231Zinc; via tele nitrogen
Metal bindingi527 – 5271Zinc; via tele nitrogen
Metal bindingi555 – 5551Zinc
Metal bindingi795 – 7951Calcium 1Imported
Metal bindingi796 – 7961Calcium 1; via carbonyl oxygenImported
Metal bindingi823 – 8231Calcium 1Imported
Metal bindingi825 – 8251Calcium 1Imported
Metal bindingi864 – 8641Calcium 1Imported
Metal bindingi1009 – 10091Calcium 2Imported
Metal bindingi1011 – 10111Calcium 2Imported
Metal bindingi1011 – 10111Calcium 3Imported
Metal bindingi1013 – 10131Calcium 3Imported
Metal bindingi1014 – 10141Calcium 3Imported
Metal bindingi1032 – 10321Calcium 2; via carbonyl oxygenImported
Metal bindingi1037 – 10371Calcium 2Imported
Metal bindingi1037 – 10371Calcium 3Imported
Metal bindingi1039 – 10391Calcium 3; via carbonyl oxygenImported
Metal bindingi1040 – 10401Calcium 2Imported
Metal bindingi1040 – 10401Calcium 3Imported

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumImported, Metal-bindingImported, ZincImported

Protein family/group databases

MEROPSiM09.002.

Names & Taxonomyi

Protein namesi
Submitted name:
CollagenaseImported
Gene namesi
Name:colGImported
OrganismiClostridium histolyticumImported
Taxonomic identifieri1498 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei5989. Clo hi Collagenase.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y3UX-ray2.55A119-880[»]
2Y50X-ray2.80A119-880[»]
2Y6IX-ray3.25A119-880[»]
2Y72X-ray1.18A/B799-880[»]
3JQUX-ray1.40A/B797-881[»]
4AQOX-ray0.99A792-880[»]
4AREX-ray2.19A119-790[»]
4HPKX-ray1.35A1006-1118[»]
B1002-1118[»]
4JRWX-ray1.60A/B797-881[»]
ProteinModelPortaliQ9X721.
SMRiQ9X721. Positions 1005-1118.

Miscellaneous databases

EvolutionaryTraceiQ9X721.

Family & Domainsi

Keywords - Domaini

CollagenImported

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR007280. Peptidase_C_arc/bac.
IPR013661. Peptidase_M9_N_dom.
IPR002169. Peptidase_M9A/M9B.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF01752. Peptidase_M9. 1 hit.
PF08453. Peptidase_M9_N. 1 hit.
PF00801. PKD. 1 hit.
PF04151. PPC. 1 hit.
[Graphical view]
PRINTSiPR00931. MICOLLPTASE.
SMARTiSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X721-1 [UniParc]FASTAAdd to Basket

« Hide

MKKNILKILM DSYSKESKIQ TVRRVTSVSL LAVYLTMNTS SLVLAKPIEN     50
TNDTSIKNVE KLRNAPNEEN SKKVEDSKND KVEHVKNIEE AKVEQVAPEV 100
KSKSTLRSAS IANTNSEKYD FEYLNGLSYT ELTNLIKNIK WNQINGLFNY 150
STGSQKFFGD KNRVQAIINA LQESGRTYTA NDMKGIETFT EVLRAGFYLG 200
YYNDGLSYLN DRNFQDKCIP AMIAIQKNPN FKLGTAVQDE VITSLGKLIG 250
NASANAEVVN NCVPVLKQFR ENLNQYAPDY VKGTAVNELI KGIEFDFSGA 300
AYEKDVKTMP WYGKIDPFIN ELKALGLYGN ITSATEWASD VGIYYLSKFG 350
LYSTNRNDIV QSLEKAVDMY KYGKIAFVAM ERITWDYDGI GSNGKKVDHD 400
KFLDDAEKHY LPKTYTFDNG TFIIRAGDKV SEEKIKRLYW ASREVKSQFH 450
RVVGNDKALE VGNADDVLTM KIFNSPEEYK FNTNINGVST DNGGLYIEPR 500
GTFYTYERTP QQSIFSLEEL FRHEYTHYLQ ARYLVDGLWG QGPFYEKNRL 550
TWFDEGTAEF FAGSTRTSGV LPRKSILGYL AKDKVDHRYS LKKTLNSGYD 600
DSDWMFYNYG FAVAHYLYEK DMPTFIKMNK AILNTDVKSY DEIIKKLSDD 650
ANKNTEYQNH IQELADKYQG AGIPLVSDDY LKDHGYKKAS EVYSEISKAA 700
SLTNTSVTAE KSQYFNTFTL RGTYTGETSK GEFKDWDEMS KKLDGTLESL 750
AKNSWSGYKT LTAYFTNYRV TSDNKVQYDV VFHGVLTDNA DISNNKAPIA 800
KVTGPSTGAV GRNIEFSGKD SKDEDGKIVS YDWDFGDGAT SRGKNSVHAY 850
KKAGTYNVTL KVTDDKGATA TESFTIEIKN EDTTTPITKE MEPNDDIKEA 900
NGPIVEGVTV KGDLNGSDDA DTFYFDVKED GDVTIELPYS GSSNFTWLVY 950
KEGDDQNHIA SGIDKNNSKV GTFKSTKGRH YVFIYKHDSA SNISYSLNIK 1000
GLGNEKLKEK ENNDSSDKAT VIPNFNTTMQ GSLLGDDSRD YYSFEVKEEG 1050
EVNIELDKKD EFGVTWTLHP ESNINDRITY GQVDGNKVSN KVKLRPGKYY 1100
LLVYKYSGSG NYELRVNK 1118
Length:1,118
Mass (Da):126,242
Last modified:November 1, 1999 - v1
Checksum:i770CF3F60E4D4FD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87215 Genomic DNA. Translation: BAA77453.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87215 Genomic DNA. Translation: BAA77453.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Y3U X-ray 2.55 A 119-880 [» ]
2Y50 X-ray 2.80 A 119-880 [» ]
2Y6I X-ray 3.25 A 119-880 [» ]
2Y72 X-ray 1.18 A/B 799-880 [» ]
3JQU X-ray 1.40 A/B 797-881 [» ]
4AQO X-ray 0.99 A 792-880 [» ]
4ARE X-ray 2.19 A 119-790 [» ]
4HPK X-ray 1.35 A 1006-1118 [» ]
B 1002-1118 [» ]
4JRW X-ray 1.60 A/B 797-881 [» ]
ProteinModelPortali Q9X721.
SMRi Q9X721. Positions 1005-1118.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 5989. Clo hi Collagenase.
MEROPSi M09.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q9X721.

Family and domain databases

Gene3Di 2.60.40.670. 1 hit.
InterProi IPR007280. Peptidase_C_arc/bac.
IPR013661. Peptidase_M9_N_dom.
IPR002169. Peptidase_M9A/M9B.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view ]
Pfami PF01752. Peptidase_M9. 1 hit.
PF08453. Peptidase_M9_N. 1 hit.
PF00801. PKD. 1 hit.
PF04151. PPC. 1 hit.
[Graphical view ]
PRINTSi PR00931. MICOLLPTASE.
SMARTi SM00089. PKD. 1 hit.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 1 hit.
PROSITEi PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene duplication and multiplicity of collagenases in Clostridium histolyticum."
    Matsushita O., Jung C.-M., Katayama S., Minami J., Takahashi Y., Okabe A.
    J. Bacteriol. 181:923-933(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JCM 1403Imported.
  2. "Crystal structure of Clostridium histolyticum colG collagenase polycystic kidney disease domain at 1.4 Angstrom resolution."
    Sakon J, Philominathan S.T.L., Matsushita O., Gunn S.
    Submitted (SEP-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 797-881.
  3. "Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis."
    Eckhard U., Schonauer E., Nuss D., Brandstetter H.
    Nat. Struct. Mol. Biol. 18:1109-1114(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.18 ANGSTROMS) OF 799-880 IN COMPLEX WITH ZINC.
  4. "Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum."
    Bauer R., Wilson J.J., Philominathan S.T., Davis D., Matsushita O., Sakon J.
    J. Bacteriol. 195:318-327(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 1006-1118 AND 1002-1118 IN COMPLEX WITH CALCIUM.
  5. "Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T."
    Eckhard U., Schonauer E., Brandstetter H.
    J. Biol. Chem. 288:20184-20194(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.99 ANGSTROMS) OF 792-880 IN COMPLEX WITH CALCIUM AND ZINC.
  6. "Crystal structure of Clostridium histolyticum colg collagenase PKD domain 2 at 1.6 Angstrom resolution."
    Sakon J., Philominathan S.T.L., Gann S., Bauer R., Matsushita O.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 797-881.

Entry informationi

Entry nameiQ9X721_CLOHI
AccessioniPrimary (citable) accession number: Q9X721
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi