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Q9X713

- PANC_CORGL

UniProt

Q9X713 - PANC_CORGL

Protein

Pantothenate synthetase

Gene

panC

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.1 Publication

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton donorBy similarity
    Binding sitei57 – 571Beta-alanineBy similarity
    Binding sitei57 – 571PantoateBy similarity
    Binding sitei153 – 1531PantoateBy similarity
    Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 338ATPBy similarity
    Nucleotide bindingi147 – 1504ATPBy similarity
    Nucleotide bindingi184 – 1874ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetase (EC:6.3.2.1)
    Short name:
    PS
    Alternative name(s):
    Pantoate--beta-alanine ligase
    Pantoate-activating enzyme
    Gene namesi
    Name:panC
    Ordered Locus Names:Cgl0113, cg0148
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Pantothenate synthetasePRO_0000128224Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi196627.cg0148.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X713.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiIADFRQW.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X713-1 [UniParc]FASTAAdd to Basket

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    MQVATTKQAL IDALLHHKSV GLVPTMGALH SGHASLVKAA RAENDTVVAS    50
    IFVNPLQFEA LGDCDDYRNY PRQLDADLAL LEEAGVDIVF APDVEEMYPG 100
    GLPLVWARTG SIGTKLEGAS RPGHFDGVAT VVAKLFNLVR PDRAYFGQKD 150
    AQQVAVIRRL VADLDIPVEI RPVPIIRGAD GLAESSRNQR LSADQRAQAL 200
    VLPQVLSGLQ RRKAAGEALD IQGARDTLAS ADGVRLDHLE IVDPATLEPL 250
    EIDGLLTQPA LVVGAIFVGP VRLIDNIEL 279
    Length:279
    Mass (Da):29,888
    Last modified:November 1, 1999 - v1
    Checksum:iEE4CF5EB4198A768
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96580 Genomic DNA. Translation: CAA65398.1.
    BA000036 Genomic DNA. Translation: BAB97506.1.
    BX927148 Genomic DNA. Translation: CAF18681.1.
    PIRiT47120.
    RefSeqiNP_599366.1. NC_003450.3.
    WP_011013399.1. NC_006958.1.
    YP_224410.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB97506; BAB97506; BAB97506.
    CAF18681; CAF18681; cg0148.
    GeneIDi1021074.
    KEGGicgb:cg0148.
    cgl:NCgl0112.
    PATRICi21492274. VBICorGlu203724_0116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96580 Genomic DNA. Translation: CAA65398.1 .
    BA000036 Genomic DNA. Translation: BAB97506.1 .
    BX927148 Genomic DNA. Translation: CAF18681.1 .
    PIRi T47120.
    RefSeqi NP_599366.1. NC_003450.3.
    WP_011013399.1. NC_006958.1.
    YP_224410.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q9X713.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg0148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB97506 ; BAB97506 ; BAB97506 .
    CAF18681 ; CAF18681 ; cg0148 .
    GeneIDi 1021074.
    KEGGi cgb:cg0148.
    cgl:NCgl0112.
    PATRICi 21492274. VBICorGlu203724_0116.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi IADFRQW.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "D-pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction."
      Eggeling L., Sahm H.
      Appl. Environ. Microbiol. 65:1973-1979(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPANC_CORGL
    AccessioniPrimary (citable) accession number: Q9X713
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3