Reviewed, UniProtKB/Swiss-Prot Q9X6Y9 (DAPB_BORPE)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BP2509

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Dihydrodipicolinate reductase		PRO_0000141415

Sequences

	Sequence		Length	Mass (Da)
	Q9X6Y9-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 68DF3E7158BDAA31	FASTA	269	28,328
	10 20 30 40 50 60 MTQATPQRIA IAGASGRMGQ MLIEAVLDTE GVELAVALDR AGSPSIGQDA GAALGRPCGV 70 80 90 100 110 120 TITDQLDALA QADCLIDFTR PEGTLQHLQA CLRHDVKMVI GTTGFDSSGR AEIKVAAQKI 130 140 150 160 170 180 AIVFAPNMSV GVNATLKLLD MAARILNSGY DVEIFEAHHR NKVDAPSGTA LIMGETVASA 190 200 210 220 230 240 WDVALPDVAT WTRHGDTGVR KPGTIGFSVV RGGDIVGDHT VFFCGTGERI EISHRSSSRA 250 260 TYAQGAVRAA RFLARQDNGL YDMQAVLGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Pradel E. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[2]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238308 Genomic DNA. Translation: CAB41012.1. BX640418 Genomic DNA. Translation: CAE42781.1.
RefSeq	NP_881136.1.
3D structure databases
HSSP	HSSP built from PDB template 1DRW based on UniProtKB P04036.
ModBase	Search...
Genome annotation databases
GeneID	2665670.
GenomeReviews	Gene locus BP2509 in contig BX470248_GR.
KEGG	bpe:BP2509.
NMPDR	fig|257313.1.peg.2210.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9X6Y9.
Enzyme and pathway databases
BioCyc	BPER257313:BP2509-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

DAPB_BORPE

Accession

Primary (citable) accession number: Q9X6Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)