Q9X6Y8 (MURB_BORPE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase EC=1.1.1.158 Alternative name(s): UDP-N-acetylmuramate dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Bordetella pertussis | ||||
| Taxonomic identifier | 520 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella |
Protein attributes
| Sequence length | 351 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Cell wall formation By similarity. HAMAP MF_00037 |
| Catalytic activity | UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037 |
| Cofactor | FAD By similarity. HAMAP MF_00037 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00037. |
| Sequence similarities | Belongs to the MurB family. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cytoplasm |
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organizationInferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | UDP-N-acetylmuramate dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 351 | 351 | UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037 | PRO_0000179183 | |||||
Regions | |||||||||
| Domain | 29 – 199 | 171 | FAD-binding PCMH-type | ||||||
Sites | |||||||||
| Active site | 175 | 1 | By similarity | ||||||
| Active site | 248 | 1 | Proton donor By similarity | ||||||
| Active site | 344 | 1 | By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | Pradel E. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251. |
| [2] | "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J.Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ238308 Genomic DNA. Translation: CAB41011.1. BX640418 Genomic DNA. Translation: CAE42782.1. |
| RefSeq | NP_881137.1. NC_002929.2. |
3D structure databases | |
| ProteinModelPortal | Q9X6Y8. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2665671. |
| GenomeReviews | Gene locus BP2510 in contig BX470248_GR. |
| KEGG | bpe:BP2510. |
| NMPDR | fig|257313.1.peg.2211. |
| PATRIC | 21158454. VBIBorPer7866_2708. |
Phylogenomic databases | |
| HOGENOM | HBG686573. |
| OMA | ISERHAN. |
| PhylomeDB | Q9X6Y8. |
| ProtClustDB | PRK00046. |
Enzyme and pathway databases | |
| BioCyc | BPER257313:BP2510-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00037. MurB. [Tree] |
| InterPro | IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N. [Graphical view] |
| Gene3D | G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.90.78.10. MurB_C. 1 hit. |
| KO | K00075. |
| PANTHER | PTHR21071. MurB. 1 hit. |
| Pfam | PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit. [Graphical view] |
| SUPFAM | SSF56176. FAD-binding_2. 1 hit. SSF56194. MurB_C. 1 hit. |
| TIGRFAMs | TIGR00179. MurB. 1 hit. |
| PROSITE | PS51387. FAD_PCMH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MURB_BORPE | ||||||||
| Accession | Primary (citable) accession number: Q9X6Y8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with