pbpA

Functionⁱ

Catalyzes cross-linking of the peptidoglycan cell wall.UniRule annotation

Catalytic activityⁱ

Preferential cleavage: (Ac)₂-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.UniRule annotation

Pathwayⁱ: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	327	Acyl-ester intermediateUniRule annotation		1

GO - Molecular functionⁱ

penicillin binding Source: InterPro
serine-type D-Ala-D-Ala carboxypeptidase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell wall organization Source: UniProtKB-KW
peptidoglycan biosynthetic process Source: UniProtKB-UniRule
regulation of cell shape Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	CarboxypeptidaseUniRule annotation, Hydrolase, Protease
Biological process	Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00219.

UniPathwayⁱ

UPA00219.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidoglycan D,D-transpeptidase MrdAUniRule annotation (EC:3.4.16.4UniRule annotation) Alternative name(s): Penicillin-binding protein 2UniRule annotation Short name: PBP-2UniRule annotation
Gene namesⁱ	Name:pbpAImported Synonyms:mrdAUniRule annotationImported, spoVDImported ORF Names:AO964_03845Imported, AOY09_05445Imported, CAZ03_33860Imported, CAZ10_26315Imported, CGU42_07245Imported, CWI21_05040Imported, PAERUG_E15_London_28_01_14_04647Imported, RW109_RW109_01676Imported
Organismⁱ	Pseudomonas aeruginosaImported
Taxonomic identifierⁱ	287 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group
Proteomesⁱ	UP000194726 Componentⁱ: Unassembled WGS sequence UP000233777 Componentⁱ: Chromosome mainomosome UP000054840 Componentⁱ: Unassembled WGS sequence UP000232017 Componentⁱ: Chromosome UP000216659 Componentⁱ: Unassembled WGS sequence UP000194857 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

Pseudomonas genome database More...PseudoCAPⁱ	PA4003.

PseudoCAPⁱ

PA4003.

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_02081
; Single-pass membrane protein
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_02081

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	21 – 40	HelicalUniRule annotationAdd BLAST		20

GO - Cellular componentⁱ

integral component of plasma membrane Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL5539.
Drug and drug target database More...DrugBankⁱ	DB01413. Cefepime. DB00438. Ceftazidime.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	64 – 236	PBP_dimerInterPro annotationAdd BLAST		173
Domainⁱ	268 – 604	TranspeptidaseInterPro annotationAdd BLAST		337

Sequence similaritiesⁱ

Belongs to the transpeptidase family. MrdA subfamily.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CJN. Bacteria. COG0768. LUCA.
HOGENOMⁱ	HOG000266120.
KEGG Orthology (KO) More...KOⁱ	K05515.

Family and domain databases

HAMAPⁱ	MF_02081. MrdA_transpept. 1 hit.
InterProⁱ	View protein in InterPro IPR012338. Beta-lactam/transpept-like. IPR005311. PBP_dimer. IPR036138. PBP_dimer_sf. IPR001460. PCN-bd_Tpept. IPR017790. Penicillin-binding_protein_2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03717. PBP_dimer. 1 hit. PF00905. Transpeptidase. 1 hit.
SUPFAMⁱ	SSF56519. SSF56519. 1 hit. SSF56601. SSF56601. 1 hit.
TIGRFAMsⁱ	TIGR03423. pbp2_mrdA. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9X6V3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPQPIHLKDH EKDARLVRRR VIVGAVAVVL LTLVLVARMY HLQVTQYEYH 
        60         70         80         90        100
STLSENNRVH VQPIPPTRGI IFDRNGVIIA DNRPSFSLTI TRERTEDLQK 
       110        120        130        140        150
TLDTLVEILG LTEDDRAIFE KRMKQGRRPF EPVPIMFELN EEQIARIAVN 
       160        170        180        190        200
QFRLPGVDVA TQFVRHYPLK EHFAHSVGYV GRINEQELKN LDPINYSGTH 
       210        220        230        240        250
HIGKTGIERF YESELHGTVG YEEVETNARG RVLRVLKRTD PIPGKDIVLS 
       260        270        280        290        300
IDSRLQEAAE NALAGRRGAI VAIQPSTGDV LAMVSQPSYD PNLFVTGISF 
       310        320        330        340        350
KAYAELRDSI DRPLYNRVLR GLYPPGSTVK PAVALAGLDA GVVTPTSRVF 
       360        370        380        390        400
DPGYYQLPNY DHKYRNWNRY GDGWVSLESA IYRSNDTYFY DLAHKLGIDR 
       410        420        430        440        450
LHAFMSRFGF GQKVALDMFG EADGLMPSRE WKRKTRRQVW YPGETLILGI 
       460        470        480        490        500
GQGYMQATPI QLAQMTALLA NKGHWIRPHL AKTIDGQPPV DPDPMPDIVL 
       510        520        530        540        550
RDPANWDRVD YGMQQVVHGA RGTARKVGAT SAYLIAGKSG TAQVVAIKQN 
       560        570        580        590        600
ERYDRSKLLE RHRDHALFVG FAPANNPQIA VAVMVENGES GSGVAAPVVK 
       610        620        630        640 
QVMDAWLLDE HGKLKAEYAE PVAPLAAAVA KPEPTAAEPE APALEQ

Length:646

Mass (Da):72,213

Last modified:November 1, 1999 - v1

Checksum:ⁱ2F4CA6F5746CCCB1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF147448 Genomic DNA. Translation: AAD32230.1. CP012901 Genomic DNA. Translation: ALV80466.1. CP025055 Genomic DNA. Translation: AUA75512.1. CVWF01000185 Genomic DNA. Translation: CRQ64476.1. LLOD01000001 Genomic DNA. Translation: KSH18796.1. NFFO01000063 Genomic DNA. Translation: OTH74495.1. NFFZ01000017 Genomic DNA. Translation: OTI57375.1. NMRQ01000014 Genomic DNA. Translation: OZO18476.1. LT969520 Genomic DNA. Translation: SOV27592.1.
PIRⁱ	G83146.
NCBI Reference Sequences More...RefSeqⁱ	NP_252692.1. NC_002516.2. WP_003093191.1. NZ_PHST01000074.1.

Genome annotation databases

EnsemblBacteriaⁱ	CRO33333; CRO33333; PAERUG_P32_London_17_VIM_2_10_11_02137. CRQ64476; CRQ64476; PAERUG_E15_London_28_01_14_04647. KSH18796; KSH18796; AO964_03845.
GeneIDⁱ	878962.
KEGGⁱ	pae:PA4003. paeb:NCGM1900_0960.
PATRICⁱ	fig\|287.1477.peg.1343.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9X6V3	A0A1G5LWR0 A0A1E9CGH7 A0A157TV25 A0A0H3QY85 A0A0E1APY3 G3XCV7 A0A1C7C7Z0 A0A0H2ZEK5 A0A1S1BS28 W1MHH1 +19	Acinetobacter baumannii Pseudomonas sp. HMSC066B11 Enterobacter cloacae Pseudomonas aeruginosa str. Stone 130 Pseudomonas aeruginosa MTB-1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Pseudomonas aeruginosa BL04 Pseudomonas aeruginosa (strain UCBPP-PA14) Pseudomonas sp. HMSC059F05 Pseudomonas aeruginosa VRFPA03 And more	646	UniRef100_A0A1G5LWR0	Cluster: Peptidoglycan D,D-transpeptidase MrdA	30

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9X6V3	A0A1G5LWR0 A0A1E9CGH7 A0A157TV25 A0A0H3QY85 A0A0E1APY3 G3XCV7 A0A1C7C7Z0 A0A0H2ZEK5 A0A1S1BS28 W1MHH1 +82	Acinetobacter baumannii Pseudomonas sp. HMSC066B11 Enterobacter cloacae Pseudomonas aeruginosa str. Stone 130 Pseudomonas aeruginosa MTB-1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Pseudomonas aeruginosa BL04 Pseudomonas aeruginosa (strain UCBPP-PA14) Pseudomonas sp. HMSC059F05 Pseudomonas aeruginosa VRFPA03 And more	646	UniRef90_A0A1G5LWR0	Cluster: Peptidoglycan D,D-transpeptidase MrdA	93

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9X6V3	Q88GI2 A5W202 UPI000313C6B2 B0KML0 UPI0002E2CFB8 UPI000441B600 A0A177SMF4 UPI000A1EE291 UPI000903A309 A0A0Q4NFA9 +1205	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) Pseudomonas putida (Arthrobacter siderocapsulatus) Pseudomonas putida (strain GB-1) Pseudomonas Lipotes vexillifer (Yangtze river dolphin) Pseudomonas sp. Leaf58 Pseudomonas putida KG-4 Pseudomonas sp. NBRC 111133 Pseudomonas sp. URMO17WK12:I11 And more	631	UniRef50_Q88GI2	Cluster: Peptidoglycan D,D-transpeptidase MrdA	1,216

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF147448 Genomic DNA. Translation: AAD32230.1. CP012901 Genomic DNA. Translation: ALV80466.1. CP025055 Genomic DNA. Translation: AUA75512.1. CVWF01000185 Genomic DNA. Translation: CRQ64476.1. LLOD01000001 Genomic DNA. Translation: KSH18796.1. NFFO01000063 Genomic DNA. Translation: OTH74495.1. NFFZ01000017 Genomic DNA. Translation: OTI57375.1. NMRQ01000014 Genomic DNA. Translation: OZO18476.1. LT969520 Genomic DNA. Translation: SOV27592.1.
PIRⁱ	G83146.
NCBI Reference Sequences More...RefSeqⁱ	NP_252692.1. NC_002516.2. WP_003093191.1. NZ_PHST01000074.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

ChEMBLⁱ	CHEMBL5539.
Drug and drug target database More...DrugBankⁱ	DB01413. Cefepime. DB00438. Ceftazidime.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CRO33333; CRO33333; PAERUG_P32_London_17_VIM_2_10_11_02137. CRQ64476; CRQ64476; PAERUG_E15_London_28_01_14_04647. KSH18796; KSH18796; AO964_03845.
GeneIDⁱ	878962.
KEGGⁱ	pae:PA4003. paeb:NCGM1900_0960.
PATRICⁱ	fig\|287.1477.peg.1343.

Organism-specific databases

Pseudomonas genome database More...PseudoCAPⁱ	PA4003.

PseudoCAPⁱ

PA4003.

Phylogenomic databases

eggNOGⁱ	ENOG4105CJN. Bacteria. COG0768. LUCA.
HOGENOMⁱ	HOG000266120.
KEGG Orthology (KO) More...KOⁱ	K05515.

Enzyme and pathway databases

UniPathwayⁱ	UPA00219.

UniPathwayⁱ

UPA00219.

Family and domain databases

HAMAPⁱ	MF_02081. MrdA_transpept. 1 hit.
InterProⁱ	View protein in InterPro IPR012338. Beta-lactam/transpept-like. IPR005311. PBP_dimer. IPR036138. PBP_dimer_sf. IPR001460. PCN-bd_Tpept. IPR017790. Penicillin-binding_protein_2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03717. PBP_dimer. 1 hit. PF00905. Transpeptidase. 1 hit.
SUPFAMⁱ	SSF56519. SSF56519. 1 hit. SSF56601. SSF56601. 1 hit.
TIGRFAMsⁱ	TIGR03423. pbp2_mrdA. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9X6V3_PSEAI
Accessionⁱ	Q9X6V3Primary (citable) accession number: Q9X6V3 Secondary accession number(s): Q7DC85
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 1, 1999
	Last sequence update:	November 1, 1999
	Last modified:	March 28, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9X6V3 (Q9X6V3_PSEAI)

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Peptidoglycan D,D-transpeptidase MrdA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: peptidoglycan biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ