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Protein
Submitted name:

Penicillin-binding protein 2

Gene

pbpA

Organism
Pseudomonas aeruginosa
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Penicillin-binding protein 2Imported
Submitted name:
Pseudomonas aeruginosa genome assembly PAE221Imported
Gene namesi
Name:pbpAImported
Synonyms:penAImported
ORF Names:ERS445055_00950Imported, PA257_1150Imported, PA8380_10240Imported, PAE221_03750Imported, YQ19_05990Imported
OrganismiPseudomonas aeruginosaImported
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000033992 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4003.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

DrugBankiDB01413. Cefepime.
DB00438. Ceftazidime.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4003.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000266120.
KOiK05515.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X6V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQPIHLKDH EKDARLVRRR VIVGAVAVVL LTLVLVARMY HLQVTQYEYH
60 70 80 90 100
STLSENNRVH VQPIPPTRGI IFDRNGVIIA DNRPSFSLTI TRERTEDLQK
110 120 130 140 150
TLDTLVEILG LTEDDRAIFE KRMKQGRRPF EPVPIMFELN EEQIARIAVN
160 170 180 190 200
QFRLPGVDVA TQFVRHYPLK EHFAHSVGYV GRINEQELKN LDPINYSGTH
210 220 230 240 250
HIGKTGIERF YESELHGTVG YEEVETNARG RVLRVLKRTD PIPGKDIVLS
260 270 280 290 300
IDSRLQEAAE NALAGRRGAI VAIQPSTGDV LAMVSQPSYD PNLFVTGISF
310 320 330 340 350
KAYAELRDSI DRPLYNRVLR GLYPPGSTVK PAVALAGLDA GVVTPTSRVF
360 370 380 390 400
DPGYYQLPNY DHKYRNWNRY GDGWVSLESA IYRSNDTYFY DLAHKLGIDR
410 420 430 440 450
LHAFMSRFGF GQKVALDMFG EADGLMPSRE WKRKTRRQVW YPGETLILGI
460 470 480 490 500
GQGYMQATPI QLAQMTALLA NKGHWIRPHL AKTIDGQPPV DPDPMPDIVL
510 520 530 540 550
RDPANWDRVD YGMQQVVHGA RGTARKVGAT SAYLIAGKSG TAQVVAIKQN
560 570 580 590 600
ERYDRSKLLE RHRDHALFVG FAPANNPQIA VAVMVENGES GSGVAAPVVK
610 620 630 640
QVMDAWLLDE HGKLKAEYAE PVAPLAAAVA KPEPTAAEPE APALEQ
Length:646
Mass (Da):72,213
Last modified:November 1, 1999 - v1
Checksum:i2F4CA6F5746CCCB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147448 Genomic DNA. Translation: AAD32230.1.
CP011317 Genomic DNA. Translation: AKE67767.1.
AP014651 Genomic DNA. Translation: BAQ37770.1.
AP014839 Genomic DNA. Translation: BAR65873.1.
CDFS01000080 Genomic DNA. Translation: CEI78130.1.
LN831024 Genomic DNA. Translation: CKG90195.1.
PIRiG83146.
RefSeqiNP_252692.1. NC_002516.2.
WP_003093191.1. NZ_KN716066.1.

Genome annotation databases

EnsemblBacteriaiCDO83506; CDO83506; PSE305_43700c.
KDR47108; KDR47108; DQ20_17770.
KEF93157; KEF93157; RLJV_10720.
KEI25384; KEI25384; CH80_25095.
KFL11105; KFL11105; DR97_3864.
KGB87456; KGB87456; JF43_11625.
KHE31747; KHE31747; LH31_28070.
KHE64001; KHE64001; D480_0209355.
GeneIDi878962.
KEGGipae:PA4003.
paeb:NCGM1900_0960.
PATRICi19842677. VBIPseAer58763_4195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147448 Genomic DNA. Translation: AAD32230.1.
CP011317 Genomic DNA. Translation: AKE67767.1.
AP014651 Genomic DNA. Translation: BAQ37770.1.
AP014839 Genomic DNA. Translation: BAR65873.1.
CDFS01000080 Genomic DNA. Translation: CEI78130.1.
LN831024 Genomic DNA. Translation: CKG90195.1.
PIRiG83146.
RefSeqiNP_252692.1. NC_002516.2.
WP_003093191.1. NZ_KN716066.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4003.

Chemistry

ChEMBLiCHEMBL5539.
DrugBankiDB01413. Cefepime.
DB00438. Ceftazidime.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO83506; CDO83506; PSE305_43700c.
KDR47108; KDR47108; DQ20_17770.
KEF93157; KEF93157; RLJV_10720.
KEI25384; KEI25384; CH80_25095.
KFL11105; KFL11105; DR97_3864.
KGB87456; KGB87456; JF43_11625.
KHE31747; KHE31747; LH31_28070.
KHE64001; KHE64001; D480_0209355.
GeneIDi878962.
KEGGipae:PA4003.
paeb:NCGM1900_0960.
PATRICi19842677. VBIPseAer58763_4195.

Organism-specific databases

PseudoCAPiPA4003.

Phylogenomic databases

HOGENOMiHOG000266120.
KOiK05515.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of PBP5 of Pseudomonas aeruginosa."
    Gagnon L.A., Castro-Urbina I.M., Liao X., Hancock R.E.W., Clarke A.J., Huletsky A.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PAO1Imported.
  2. Manrique Marina
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Pae221_ST274Imported.
  3. Akiyama T., Kubota S., Kirikae T.
    Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCGM257Imported.
  4. "Draft Genome Sequence of the Quorum-Sensing and Biofilm-Producing Pseudomonas aeruginosa Strain Pae221, Belonging to the Epidemic High-Risk Clone Sequence Type 274."
    Ocampo-Sosa A.A., Fernandez-Martinez M., Cabot G., Pena C., Tubau F., Oliver A., Martinez-Martinez L.
    Genome Announc. 3:1-2(2015)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Pae221_ST274Imported.
  5. "Complete Genome Sequence of Pseudomonas aeruginosa Strain 8380, Isolated from the Human Gut."
    Ichise Y., Kosuge T., Uwate M., Nakae T., Maseda H.
    Genome Announc. 0:0-0(2015)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 8380Imported.
  6. "Molecular epidemiological risk assessment of nosocomial infection of Pseudomonas aeruginosa."
    Miyoshi-Akiyama T., Kubota S., Kirikae T.
    Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCGM257Imported.
  7. Informatics Pathogen
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCTC10332Imported.
  8. "Pseudomonas aeruginosa Carb 01 63."
    Kraak W., van der Zee A.
    Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Carb01 63Imported.

Entry informationi

Entry nameiQ9X6V3_PSEAI
AccessioniPrimary (citable) accession number: Q9X6V3
Secondary accession number(s): Q7DC85
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.