UniProtKB - Q9X6V3 (Q9X6V3_PSEAI)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Peptidoglycan D,D-transpeptidase MrdA
Gene
pbpA
Organism
Pseudomonas aeruginosa
Status
Functioni
Catalyzes cross-linking of the peptidoglycan cell wall.UniRule annotation
Catalytic activityi
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.UniRule annotation
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 327 | Acyl-ester intermediateUniRule annotation | 1 |
GO - Molecular functioni
- penicillin binding Source: InterPro
- serine-type D-Ala-D-Ala carboxypeptidase activity Source: UniProtKB-UniRule
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotation, Hydrolase, Protease |
Biological process | Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation |
Enzyme and pathway databases
UniPathwayi | UPA00219. |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidoglycan D,D-transpeptidase MrdAUniRule annotation (EC:3.4.16.4UniRule annotation)Alternative name(s): Penicillin-binding protein 2UniRule annotation Short name: PBP-2UniRule annotation |
Gene namesi | Name:pbpAImported Synonyms:mrdAUniRule annotationImported, spoVDImported ORF Names:AO964_03845Imported, AOY09_05445Imported, CAZ03_33860Imported, CAZ10_26315Imported, CGU42_07245Imported, CWI21_05040Imported, PAERUG_E15_London_28_01_14_04647Imported, RW109_RW109_01676Imported |
Organismi | Pseudomonas aeruginosaImported |
Taxonomic identifieri | 287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA4003. |
Subcellular locationi
- Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 40 | HelicalUniRule annotationAdd BLAST | 20 |
GO - Cellular componenti
- integral component of plasma membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Cell inner membraneUniRule annotation, Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL5539. |
DrugBanki | DB01413. Cefepime. DB00438. Ceftazidime. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 236 | PBP_dimerInterPro annotationAdd BLAST | 173 | |
Domaini | 268 – 604 | TranspeptidaseInterPro annotationAdd BLAST | 337 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
eggNOGi | ENOG4105CJN. Bacteria. COG0768. LUCA. |
HOGENOMi | HOG000266120. |
KOi | K05515. |
Family and domain databases
HAMAPi | MF_02081. MrdA_transpept. 1 hit. |
InterProi | View protein in InterPro IPR012338. Beta-lactam/transpept-like. IPR005311. PBP_dimer. IPR036138. PBP_dimer_sf. IPR001460. PCN-bd_Tpept. IPR017790. Penicillin-binding_protein_2. |
Pfami | View protein in Pfam PF03717. PBP_dimer. 1 hit. PF00905. Transpeptidase. 1 hit. |
SUPFAMi | SSF56519. SSF56519. 1 hit. SSF56601. SSF56601. 1 hit. |
TIGRFAMsi | TIGR03423. pbp2_mrdA. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9X6V3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQPIHLKDH EKDARLVRRR VIVGAVAVVL LTLVLVARMY HLQVTQYEYH
60 70 80 90 100
STLSENNRVH VQPIPPTRGI IFDRNGVIIA DNRPSFSLTI TRERTEDLQK
110 120 130 140 150
TLDTLVEILG LTEDDRAIFE KRMKQGRRPF EPVPIMFELN EEQIARIAVN
160 170 180 190 200
QFRLPGVDVA TQFVRHYPLK EHFAHSVGYV GRINEQELKN LDPINYSGTH
210 220 230 240 250
HIGKTGIERF YESELHGTVG YEEVETNARG RVLRVLKRTD PIPGKDIVLS
260 270 280 290 300
IDSRLQEAAE NALAGRRGAI VAIQPSTGDV LAMVSQPSYD PNLFVTGISF
310 320 330 340 350
KAYAELRDSI DRPLYNRVLR GLYPPGSTVK PAVALAGLDA GVVTPTSRVF
360 370 380 390 400
DPGYYQLPNY DHKYRNWNRY GDGWVSLESA IYRSNDTYFY DLAHKLGIDR
410 420 430 440 450
LHAFMSRFGF GQKVALDMFG EADGLMPSRE WKRKTRRQVW YPGETLILGI
460 470 480 490 500
GQGYMQATPI QLAQMTALLA NKGHWIRPHL AKTIDGQPPV DPDPMPDIVL
510 520 530 540 550
RDPANWDRVD YGMQQVVHGA RGTARKVGAT SAYLIAGKSG TAQVVAIKQN
560 570 580 590 600
ERYDRSKLLE RHRDHALFVG FAPANNPQIA VAVMVENGES GSGVAAPVVK
610 620 630 640
QVMDAWLLDE HGKLKAEYAE PVAPLAAAVA KPEPTAAEPE APALEQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF147448 Genomic DNA. Translation: AAD32230.1. CP012901 Genomic DNA. Translation: ALV80466.1. CP025055 Genomic DNA. Translation: AUA75512.1. CVWF01000185 Genomic DNA. Translation: CRQ64476.1. LLOD01000001 Genomic DNA. Translation: KSH18796.1. NFFO01000063 Genomic DNA. Translation: OTH74495.1. NFFZ01000017 Genomic DNA. Translation: OTI57375.1. NMRQ01000014 Genomic DNA. Translation: OZO18476.1. LT969520 Genomic DNA. Translation: SOV27592.1. |
PIRi | G83146. |
RefSeqi | NP_252692.1. NC_002516.2. WP_003093191.1. NZ_PHST01000074.1. |
Genome annotation databases
EnsemblBacteriai | CRO33333; CRO33333; PAERUG_P32_London_17_VIM_2_10_11_02137. CRQ64476; CRQ64476; PAERUG_E15_London_28_01_14_04647. KSH18796; KSH18796; AO964_03845. |
GeneIDi | 878962. |
KEGGi | pae:PA4003. paeb:NCGM1900_0960. |
PATRICi | fig|287.1477.peg.1343. |
Similar proteinsi
Entry informationi
Entry namei | Q9X6V3_PSEAI | |
Accessioni | Q9X6V3Primary (citable) accession number: Q9X6V3 Secondary accession number(s): Q7DC85 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1999 |
Last sequence update: | November 1, 1999 | |
Last modified: | March 28, 2018 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |