Reviewed,
UniProtKB/Swiss-Prot Q9X6U2 (BDHA_RALEH)
Last modified
February 9, 2010.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: D-beta-hydroxybutyrate dehydrogenase Short name=BDH EC=1.1.1.30 Alternative name(s): 3-hydroxybutyrate dehydrogenase Short name=3-HBDH | ||||
| Gene names |
| ||||
| Organism | Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 381666 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus |
Protein attributes
| Sequence length | 258 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-hydroxybutyrate dehydrogenase activity Inferred from electronic annotation. Source: EC bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 258 | 258 | D-beta-hydroxybutyrate dehydrogenase | PRO_0000054527 | |||||
Regions | |||||||||
| Nucleotide binding | 8 – 32 | 25 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 153 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 140 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 236 | 1 | L → Q in AAD33952. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequencing of the gene for beta-hydroxybutyrate dehydrogenase from Ralstonia eutropha." Kim J.W., Kang D.G., Rha E.G. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16." Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B. Nat. Biotechnol. 24:1257-1262(2006) [PubMed: 16964242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF145230 Genomic DNA. Translation: AAD33952.1. AM260479 Genomic DNA. Translation: CAJ92474.1. |
| RefSeq | YP_725842.1. |
3D structure databases | |
| SMR | Q9X6U2. Positions 2-258. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9X6U2. |
Genome annotation databases | |
| GeneID | 4249460. |
| GenomeReviews | Gene locus H16_A1334 in contig AM260479_GR. |
| KEGG | reh:H16_A1334. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1028. |
| HOGENOM | HBG750976. |
| OMA | GDSSHAR. |
| PhylomeDB | Q9X6U2. |
Family and domain databases | |
| InterPro | IPR011294. 3-OHbutyrate_DH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| TIGRFAMs | TIGR01963. PHB_DH. 1 hit. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BDHA_RALEH | ||||||||
| Accession | Primary (citable) accession number: Q9X6U2 Secondary accession number(s): Q0KBZ7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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