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Reviewed, UniProtKB/Swiss-Prot Q9X6U2 (BDHA_RALEH)

Last modified November 4, 2008. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    D-beta-hydroxybutyrate dehydrogenase
      Short name=BDH
    EC=1.1.1.30
Alternative name(s):
    3-hydroxybutyrate dehydrogenase
      Short name=3-HBDH
Gene names
Name: hbdH1
Ordered Locus Names: H16_A1334
OrganismRalstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)) [Complete proteome] [HAMAP]
Taxonomic identifier381666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

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Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Ontologies

Keywords

   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258D-beta-hydroxybutyrate dehydrogenase
PRO_0000054527

Regions

Nucleotide binding8 – 3225NAD By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site1401Substrate By similarity

Experimental info

Sequence conflict2361L → Q in AAD33952. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q9X6U2-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0B9A06D6CD97EF35

FASTA25826,999
        10         20         30         40         50         60 
MLNGKTALVT GSTSGIGLGI AKALAAQGAN IIVNGFGDAD AAKAEIAQAG QGIRVGYHGA 

        70         80         90        100        110        120 
DMSKAAEIED MMRYAQSDFG GADILVNNAG IQHVAAIEDF PPERWDAIIA INLTSAFHTT 

       130        140        150        160        170        180 
RLALPGMKQK DWGRIINVAS THGLVASAQK SAYVAAKHGI VGFTKVTALE TAQTGVTANA 

       190        200        210        220        230        240 
ICPGWVLTPL VQKQVEARAQ KEGIPVEQAK RELVLEKQPS GQFVTPDELG ALAVFLSSEA 

       250 
ARQVRGAIWN MDGGWVAQ

« Hide

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References

« Hide 'large scale' references
[1]"Cloning and sequencing of the gene for beta-hydroxybutyrate dehydrogenase from Ralstonia eutropha."
Kim J.W., Kang D.G., Rha E.G.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16."
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.
Nat. Biotechnol. 24:1257-1262(2006) [PubMed: 16964242] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AF145230 Genomic DNA. Translation: AAD33952.1.
AM260479 Genomic DNA. Translation: CAJ92474.1.
RefSeqYP_725842.1.

3D structure databases

HSSPHSSP built from PDB template 1EDO based on UniProtKB Q93X62.
ModBaseSearch...

Genome annotation databases

GeneID4249460.
GenomeReviewsGene locus H16_A1334 in contig AM260479_GR.
KEGGreh:H16_A1334.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9X6U2.

Family and domain databases

InterProIPR011294. 3-OHbutyrate_DHase.
IPR002198. DHase_sc/Rdtase_SDR.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
TIGRFAMsTIGR01963. PHB_DH. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameBDHA_RALEH
AccessionPrimary (citable) accession number: Q9X6U2
Secondary accession number(s): Q0KBZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 4, 2008
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents