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Protein

Transcription attenuation protein MtrB

Gene

mtrB

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription attenuation protein MtrB
Alternative name(s):
Trp RNA-binding attenuation protein
Short name:
TRAP
Tryptophan RNA-binding attenuator protein
Gene namesi
Name:mtrB
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7474Transcription attenuation protein MtrBPRO_0000206027Add
BLAST

Interactioni

Subunit structurei

Oligomer of 11 identical subunits arranged in doughnut-like structure.

Protein-protein interaction databases

DIPiDIP-29104N.

Structurei

Secondary structure

1
74
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 148Combined sources
Beta strandi17 – 237Combined sources
Beta strandi25 – 273Combined sources
Beta strandi30 – 367Combined sources
Beta strandi41 – 455Combined sources
Beta strandi48 – 6316Combined sources
Beta strandi66 – 683Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C9SX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
1GTFX-ray1.75A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
1GTNX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
1QAWX-ray2.50A/B/C/D/E/F/G/H/I/J/K1-74[»]
1UTDX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
2EXSX-ray2.00A/B/C2-74[»]
2EXTX-ray1.80A/B/C2-74[»]
2ZCZX-ray1.80A/B/C/D/E/F1-74[»]
2ZD0X-ray2.50A/B/C1-74[»]
2ZP8X-ray3.20A/B/C/D1-74[»]
2ZP9X-ray3.20A/B/F/G/K/L1-74[»]
3AQDX-ray3.20A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
3ZZSX-ray1.49A/B/C/D/E/F/G/H/I5-69[»]
4V4FX-ray1.90AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/AS/AT/AU/AV/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL/BM/BN/BO/BP/BQ/BR/BS/BT/BU/BV1-74[»]
ProteinModelPortaliQ9X6J6.
SMRiQ9X6J6. Positions 3-73.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X6J6.

Family & Domainsi

Sequence similaritiesi

Belongs to the MtrB family.Curated

Family and domain databases

Gene3Di2.60.40.50. 1 hit.
HAMAPiMF_00798. Trp_attenuator.
InterProiIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamiPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSiPR00687. TRPRNAAP.
SUPFAMiSSF51219. SSF51219. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X6J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTNSDFVVI KALEDGVNVI GLTRGADTRF HHSEKLDKGE VLIAQFTEHT
60 70
SAIKVRGKAY IQTRHGVIES EGKK
Length:74
Mass (Da):8,242
Last modified:November 1, 1999 - v1
Checksum:iB3E22117331531CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139535 Genomic DNA. Translation: AAD33793.1.
RefSeqiWP_033013997.1. NZ_LQYY01000023.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139535 Genomic DNA. Translation: AAD33793.1.
RefSeqiWP_033013997.1. NZ_LQYY01000023.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C9SX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
1GTFX-ray1.75A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
1GTNX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
1QAWX-ray2.50A/B/C/D/E/F/G/H/I/J/K1-74[»]
1UTDX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
2EXSX-ray2.00A/B/C2-74[»]
2EXTX-ray1.80A/B/C2-74[»]
2ZCZX-ray1.80A/B/C/D/E/F1-74[»]
2ZD0X-ray2.50A/B/C1-74[»]
2ZP8X-ray3.20A/B/C/D1-74[»]
2ZP9X-ray3.20A/B/F/G/K/L1-74[»]
3AQDX-ray3.20A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-74[»]
3ZZSX-ray1.49A/B/C/D/E/F/G/H/I5-69[»]
4V4FX-ray1.90AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/AS/AT/AU/AV/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL/BM/BN/BO/BP/BQ/BR/BS/BT/BU/BV1-74[»]
ProteinModelPortaliQ9X6J6.
SMRiQ9X6J6. Positions 3-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29104N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X6J6.

Family and domain databases

Gene3Di2.60.40.50. 1 hit.
HAMAPiMF_00798. Trp_attenuator.
InterProiIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamiPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSiPR00687. TRPRNAAP.
SUPFAMiSSF51219. SSF51219. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus."
    Chen X.-P., Antson A.A., Yang M., Baumann C., Dodson E.J., Dodson G.G., Gollnick P.
    J. Mol. Biol. 289:1003-1016(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
    Strain: ATCC 12980 / NCA 26.

Entry informationi

Entry nameiMTRB_GEOSE
AccessioniPrimary (citable) accession number: Q9X6J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.