Reviewed, UniProtKB/Swiss-Prot Q9X6J4 (TRPE_BACST)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Bacillus stearothermophilus (Geobacillus stearothermophilus)

Taxonomic identifier

1422 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Anthranilate synthase component 1		PRO_0000154078

Sequences

	Sequence		Length	Mass (Da)
	Q9X6J4-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 25EB252616160ADD	FASTA	508	56,441
	10 20 30 40 50 60 MSIDRLAAFL ADARQFRTIP IMRKFLADVI EPLQVFANLR EEAVFLLESK DDESPWARYS 70 80 90 100 110 120 FIGVAPFLTL ESETGETFLI KDENGNVQMT ASTLKEAFQA VERALCVKPL AEAAPFTGGA 130 140 150 160 170 180 VGFLGYDFIS AIEKVPRHRA PDLAMKAGHF VFCESLFAFD HEKRELSLIH YIRLKGHETM 190 200 210 220 230 240 QEKIAIYRAA EERIAALAAK ASRPRAEQPL LPAEDEAERA ALFSKASSNY EKEQFLRDVE 250 260 270 280 290 300 AVKQYIAAGD VFQAVLSQRF SVPVQAGGFA IYRILRHINP SPYMFYFRLD GIEIVGSSPE 310 320 330 340 350 360 KLIQVRNRRA EIDPIAGTRR RGRSPAEDEK LADELYHDPK ERAEHYMLVD LARNDIGRVA 370 380 390 400 410 420 KYGTVEVPVL MEIGKFSHVM HLISKVVGVL DDDIHPIDAL LAAFPAGTVS GAPKVRAMQI 430 440 450 460 470 480 LQELEPTARG LYAGAIAYIG FDGSIDSCIA IRTAVIKDGY AYVQAGAGIV ADSVPELEWK 490 500 ETRNKASALI YAIEQAERLF AKGEQIVC

References

[1]

"Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus." Chen X.-P., Antson A.A., Yang M., Baumann C., Dodson E.J., Dodson G.G., Gollnick P. J. Mol. Biol. 289:1003-1016(1999) [PubMed: 10369778] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 12980 / NCA 26.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF139534 Genomic DNA. Translation: AAD33791.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0G based on UniProtKB P05041.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.3.27. 266715.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR005256. Anth_synthI. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00564. trpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BACST

Accession

Primary (citable) accession number: Q9X6J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)