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Protein

Catalase-peroxidase

Gene

katG

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Transition state stabilizerUniRule annotation1
Active sitei103Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2640 YpCP01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Antigen 5
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Synonyms:katY
Ordered Locus Names:YPO3319, y0870, YP_0367
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Periplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotation1 PublicationAdd BLAST23
ChainiPRO_000005557824 – 737Catalase-peroxidaseAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-102)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PaxDbiQ9X6B0
PRIDEiQ9X6B0

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

IntActiQ9X6B0, 8 interactors
STRINGi187410.y0870

Structurei

3D structure databases

ProteinModelPortaliQ9X6B0
SMRiQ9X6B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiEPEEIFW

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9X6B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKILPVLI TLAIVHNTPT AWAAEAPKTD SFYLPKSLDL SPLRLHNIES
60 70 80 90 100
NPYGKDFNYA QQFKTLDLEA VKKDIKTVLT TSQDWWPADY GNYGPFFIRM
110 120 130 140 150
AWHGAGTYRI YDGRGGADGG QQRFEPLNSW PDNANLDKAR RLLWPIKKKY
160 170 180 190 200
GAKISWGDLM VLTGNVALES MGFKTLGFAG GREDDWQSDL VYWGAGNKML
210 220 230 240 250
SDNRDKNGKL PKPLAATQMG LIYVNPEGPN GKPDPVAAAK DIREAFARMA
260 270 280 290 300
MNDEETVALI AGGHTFGKAH GAASPEKCLG AAPGEAGLEQ QGLGWANKCG
310 320 330 340 350
SGNGKDTITS GLEGAWTTDP THFTMQYLSN LYKHEWVLTK SPAGAWQWKP
360 370 380 390 400
KNAANVVPDA TDPTKFHPLM MFTTDIALKV DPEYKKITTR FLENPEEFKM
410 420 430 440 450
AFARAWFKLT HRDMGPAARY LGDEVPKETF IWQDPLPAAN YKMIDSADIS
460 470 480 490 500
ELKDKILKTG LSDTKLIKTA WASASTFRGT DFRGGDNGAR IRLAPQKDWP
510 520 530 540 550
VNDPAELHSV LAALMEVQNN FNKDRSDGKK VSLSDLIVLG GNAAIEDAAK
560 570 580 590 600
KAGYSISIPF TPGRTDASQE ETDVSSFAVL EPTADGFRNY YDAKRNTLSP
610 620 630 640 650
IASLIDRANK LELTVPEMTV LIGGLRVLDV NSGGSKAGVL TNTPGQLNNN
660 670 680 690 700
FFVNLLDMST KWTKSPKAEG YFDGYDRKTG KLKWTASSVD LVFGSNPELR
710 720 730
AVAEVYASDD AKEKFVHDFT KVWEKVMNLD RFDIKNN
Length:737
Mass (Da):81,365
Last modified:November 1, 1999 - v1
Checksum:iDB870BC41ABD469A
GO

Sequence cautioni

The sequence AAM84455 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS60640 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135170 Genomic DNA Translation: AAD37313.1
AL590842 Genomic DNA Translation: CAL21910.1
AE009952 Genomic DNA Translation: AAM84455.1 Different initiation.
AE017042 Genomic DNA Translation: AAS60640.1 Different initiation.
PIRiAC0403
RefSeqiWP_002209433.1, NZ_PDBR01000056.1
YP_002348215.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84455; AAM84455; y0870
AAS60640; AAS60640; YP_0367
GeneIDi1176138
KEGGiype:YPO3319
ypj:CH55_1899
ypk:y0870
ypl:CH46_1776
ypm:YP_0367
ypv:BZ15_204
ypw:CH59_2730
PATRICifig|214092.21.peg.3790

Similar proteinsi

Entry informationi

Entry nameiKATG_YERPE
AccessioniPrimary (citable) accession number: Q9X6B0
Secondary accession number(s): Q0WBX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health