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Protein

Catalase-peroxidase

Gene

katG

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Transition state stabilizerUniRule annotation1
Active sitei103Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2640. YpCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Antigen 5
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Synonyms:katY
Ordered Locus Names:YPO3319, y0870, YP_0367
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Periplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotation1 PublicationAdd BLAST23
ChainiPRO_000005557824 – 737Catalase-peroxidaseAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-102)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ9X6B0.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

IntActiQ9X6B0. 8 interactors.
STRINGi187410.y0870.

Structurei

3D structure databases

ProteinModelPortaliQ9X6B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9X6B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKILPVLI TLAIVHNTPT AWAAEAPKTD SFYLPKSLDL SPLRLHNIES
60 70 80 90 100
NPYGKDFNYA QQFKTLDLEA VKKDIKTVLT TSQDWWPADY GNYGPFFIRM
110 120 130 140 150
AWHGAGTYRI YDGRGGADGG QQRFEPLNSW PDNANLDKAR RLLWPIKKKY
160 170 180 190 200
GAKISWGDLM VLTGNVALES MGFKTLGFAG GREDDWQSDL VYWGAGNKML
210 220 230 240 250
SDNRDKNGKL PKPLAATQMG LIYVNPEGPN GKPDPVAAAK DIREAFARMA
260 270 280 290 300
MNDEETVALI AGGHTFGKAH GAASPEKCLG AAPGEAGLEQ QGLGWANKCG
310 320 330 340 350
SGNGKDTITS GLEGAWTTDP THFTMQYLSN LYKHEWVLTK SPAGAWQWKP
360 370 380 390 400
KNAANVVPDA TDPTKFHPLM MFTTDIALKV DPEYKKITTR FLENPEEFKM
410 420 430 440 450
AFARAWFKLT HRDMGPAARY LGDEVPKETF IWQDPLPAAN YKMIDSADIS
460 470 480 490 500
ELKDKILKTG LSDTKLIKTA WASASTFRGT DFRGGDNGAR IRLAPQKDWP
510 520 530 540 550
VNDPAELHSV LAALMEVQNN FNKDRSDGKK VSLSDLIVLG GNAAIEDAAK
560 570 580 590 600
KAGYSISIPF TPGRTDASQE ETDVSSFAVL EPTADGFRNY YDAKRNTLSP
610 620 630 640 650
IASLIDRANK LELTVPEMTV LIGGLRVLDV NSGGSKAGVL TNTPGQLNNN
660 670 680 690 700
FFVNLLDMST KWTKSPKAEG YFDGYDRKTG KLKWTASSVD LVFGSNPELR
710 720 730
AVAEVYASDD AKEKFVHDFT KVWEKVMNLD RFDIKNN
Length:737
Mass (Da):81,365
Last modified:November 1, 1999 - v1
Checksum:iDB870BC41ABD469A
GO

Sequence cautioni

The sequence AAM84455 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS60640 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135170 Genomic DNA. Translation: AAD37313.1.
AL590842 Genomic DNA. Translation: CAL21910.1.
AE009952 Genomic DNA. Translation: AAM84455.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS60640.1. Different initiation.
PIRiAC0403.
RefSeqiWP_002209433.1. NZ_LQBA01000050.1.
YP_002348215.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84455; AAM84455; y0870.
AAS60640; AAS60640; YP_0367.
GeneIDi1176138.
KEGGiype:YPO3319.
ypj:CH55_1899.
ypk:y0870.
ypl:CH46_1776.
ypm:YP_0367.
ypv:BZ15_204.
ypw:CH59_2730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135170 Genomic DNA. Translation: AAD37313.1.
AL590842 Genomic DNA. Translation: CAL21910.1.
AE009952 Genomic DNA. Translation: AAM84455.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS60640.1. Different initiation.
PIRiAC0403.
RefSeqiWP_002209433.1. NZ_LQBA01000050.1.
YP_002348215.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ9X6B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9X6B0. 8 interactors.
STRINGi187410.y0870.

Protein family/group databases

PeroxiBasei2640. YpCP01.

Proteomic databases

PRIDEiQ9X6B0.

Protocols and materials databases

DNASUi1145817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84455; AAM84455; y0870.
AAS60640; AAS60640; YP_0367.
GeneIDi1176138.
KEGGiype:YPO3319.
ypj:CH55_1899.
ypk:y0870.
ypl:CH46_1776.
ypm:YP_0367.
ypv:BZ15_204.
ypw:CH59_2730.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_YERPE
AccessioniPrimary (citable) accession number: Q9X6B0
Secondary accession number(s): Q0WBX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.