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Q9X670 (G6PI_STRMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Synonyms:gpi
Ordered Locus Names:SMU_307
OrganismStreptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]
Taxonomic identifier210007 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180737

Sites

Active site2911Proton donor By similarity
Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9X670 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 6ADB7E073F86A202

FASTA44949,422
        10         20         30         40         50         60 
MTHIKFDYSK VLGKFLASHE LDYIQMQVTA ADEALRKGTG PGAEMTGWLN LPQNYDKEEF 

        70         80         90        100        110        120 
ARIKKAAEKI KSDSEVLVVI GIGGSYLGAR AAIDFLNSSF VNLENKEERK APQILYAGNS 

       130        140        150        160        170        180 
ISSNYLADLV DYVADKDFSV NVISKSGTTT EPAIAFRVFK DLLVKKYGQE EANQRIYATT 

       190        200        210        220        230        240 
DRVKGAVKVE ADANGWETFV VPDSVGGRFT VLTAVGLLPI AASGADLDQL MAGAEAARQD 

       250        260        270        280        290        300 
YSSAELSENE AYQYAAIRNI LYRKGYVTEV LANYEPSLQY FSEWWKQLAG ESEGKDQKGI 

       310        320        330        340        350        360 
YPTSANFSTD LHSLGQFIQE GNRNLFETVI RVEKARKNIL VPEAAEDLDG LAYLQGKDVD 

       370        380        390        400        410        420 
FVNKKATDGV LLAHTDGGVP NTFLTIPEQD EFTLGYVIYF FELAIGLSGY LNGVNPFDQP 

       430        440 
GVEAYKKNMF ALLGKPGFEE LGAELNARL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the operon for the sorbitol (glucitol) phosphoenolpyruvate:sugar phosphotransferase system in Streptococcus mutans."
Boyd D.A., Thevenot T., Gumbmann M., Honeyman A.L., Hamilton I.R.
Infect. Immun. 68:925-930(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT11.
[2]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132127 Genomic DNA. Translation: AAD33517.1.
AE014133 Genomic DNA. Translation: AAN58070.1.
PIRT51720.
RefSeqNP_720764.1. NC_004350.2.

3D structure databases

ProteinModelPortalQ9X670.
SMRQ9X670. Positions 3-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING210007.SMU.307.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN58070; AAN58070; SMU_307.
GeneID1029442.
KEGGsmu:SMU_307.
PATRIC19662861. VBIStrMut61772_0266.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMAKVNMFAL.
OrthoDBEOG64R61J.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycSMUT210007:GC7Z-316-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_STRMU
AccessionPrimary (citable) accession number: Q9X670
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways