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Protein

Copper-transporting P-type ATPase

Gene

actP

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in copper efflux.

Catalytic activityi

ATP + H2O + Cu2+(Side 1) = ADP + phosphate + Cu2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26CopperPROSITE-ProRule annotation1
Metal bindingi29CopperPROSITE-ProRule annotation1
Metal bindingi93CopperPROSITE-ProRule annotation1
Metal bindingi96CopperPROSITE-ProRule annotation1
Active sitei5154-aspartylphosphate intermediateBy similarity1
Metal bindingi714MagnesiumPROSITE-ProRule annotation1
Metal bindingi718MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting P-type ATPase (EC:3.6.3.4)
Gene namesi
Name:actP
Ordered Locus Names:Smed_4897
Encoded oniPlasmid pSMED010 Publication
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001108 Componenti: Plasmid pSMED01

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Transmembranei727 – 747HelicalSequence analysisAdd BLAST21
Transmembranei773 – 793HelicalSequence analysisAdd BLAST21
Transmembranei795 – 815HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463291 – 827Copper-transporting P-type ATPaseAdd BLAST827

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Transcriptionally regulated by HmrR in response to Cu+ ions.

Structurei

3D structure databases

ProteinModelPortaliQ9X5X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 81HMA 1PROSITE-ProRule annotationAdd BLAST66
Domaini83 – 149HMA 2PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Contains 2 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK17686.
OMAiQAWVQAD.
OrthoDBiPOG091H00YH.

Family and domain databases

CDDicd00371. HMA. 2 hits.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X5X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALKQTEKS TSLPMSFDFD IEGMTCASCV RRVEKAIAAV PGVASANVNL
60 70 80 90 100
ATERATVQFN GVPETTSVLR AVEKAGYAPR IVTEEIQIEG MTCASCVSRV
110 120 130 140 150
EKALKAVPGV ADASVNLATE KATVRLVSGS AEISALAAAV KGAGYGIRKA
160 170 180 190 200
TPAEAMKEDV DHRTAELRSL KSAVTISSLM TLPLFLLEMG SHFIPGVHDF
210 220 230 240 250
IMGTIGMRNN LYLQFALATL VLFGPGLRFF RKGVPNLLRW TPDMNSLVVL
260 270 280 290 300
GTTAAWGYSV VTTFVPAILP SGTANVYYEA AAVIVTLILV GRYLESRAKG
310 320 330 340 350
RTSQAIKRLV GLQPKTAFVL HSGEFVETEI TEVVTGDVIR IRPGEKIPVD
360 370 380 390 400
GTVTDGSSYV DESMITGEPV PVQKATDSAV IGGTINKTGS ITFKATKVGS
410 420 430 440 450
DTLLAQIIRL VEAAQGSKLP IQALVDRVTA WFVPVVILAA LLTFAAWYVL
460 470 480 490 500
GPSPALSFAL VNAVAVLIIA CPCAMGLATP TSIMVGTGRA AELGILFRKG
510 520 530 540 550
EALQSLRDAD VVAVDKTGTL TKGRPELTDL VAAEGFEPDE VLCLVASLET
560 570 580 590 600
LSEHPIAEAI VSAAKSRGIA TVAVSAFEAT PGFGVSGTVS GRRVLVGADR
610 620 630 640 650
ALVKNGIDIT GFADEAERLG SGGKSPLYAA IDGRLAAIVA VSDPVKESTP
660 670 680 690 700
QAIKSLHALG LKVAMVTGDN RRTAEAIAKK LGIDEVVAEV LPEGKVDAVR
710 720 730 740 750
KLRQGGRSVA FIGDGINDAP ALAEADVGIA VGTGTDIAIE SADVVLMSGD
760 770 780 790 800
LNGVAKALAL SKATIRNIKQ NLFWAFVYNI SLVPVAAGVL YPVNGTLLSP
810 820
IFAAAAMAMS SVFVLGNALR LKSFDPA
Length:827
Mass (Da):86,239
Last modified:November 1, 1999 - v1
Checksum:i707E2148DDDA5004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129004 Genomic DNA. Translation: AAD27639.1.
CP000739 Genomic DNA. Translation: ABR63681.1.
RefSeqiWP_012061811.1. NC_009620.1.
YP_001313614.1. NC_009620.1.

Genome annotation databases

EnsemblBacteriaiABR63681; ABR63681; Smed_4897.
GeneIDi5318235.
KEGGismd:Smed_4897.
PATRICi23615407. VBISinMed134228_1375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129004 Genomic DNA. Translation: AAD27639.1.
CP000739 Genomic DNA. Translation: ABR63681.1.
RefSeqiWP_012061811.1. NC_009620.1.
YP_001313614.1. NC_009620.1.

3D structure databases

ProteinModelPortaliQ9X5X3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR63681; ABR63681; Smed_4897.
GeneIDi5318235.
KEGGismd:Smed_4897.
PATRICi23615407. VBISinMed134228_1375.

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK17686.
OMAiQAWVQAD.
OrthoDBiPOG091H00YH.

Family and domain databases

CDDicd00371. HMA. 2 hits.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATCU_SINMW
AccessioniPrimary (citable) accession number: Q9X5X3
Secondary accession number(s): A6UJ51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.