Reviewed, UniProtKB/Swiss-Prot Q9X5V1 (AHPD_STRVD)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Synonyms:	ahpX

Organism

Streptomyces viridosporus

Taxonomic identifier

67581 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity.
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359511
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9X5V1-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: EA39EBEECDB18AE7	FASTA	174	18,808
	10 20 30 40 50 60 MSLDSLKSRI PDYAKDLKLN LGSVIGNSGL PAQQLWGTVL STAIASRSAI VLRELEPEAK 70 80 90 100 110 120 ANLSPEAYTA AKAAAAVMAM NNVFYRTRHL LSDHEYGNLR AGLRMNVIGN PGVDKVDFEF 130 140 150 160 170 WSFAVSAING CGMCLDSTKQ VLRKAGVERR SSRRRSDCRG TQAVAATLDA EAFS

References

[1]

"Isolation and analysis of three peroxide sensor regulatory gene homologs ahpC, ahpX and oxyR in Streptomyces viridosporus T7A -- a lignocellulose degrading actinomycete." Ramachandran S., Magnuson T.S., Crawford D.L. DNA Seq. 11:51-60(2000) [PubMed: 10902909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: T7A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF127576 Genomic DNA. Translation: AAD33341.1.
3D structure databases
HSSP	HSSP built from PDB template 1KNC based on UniProtKB Q57353.
ModBase	Search...
Protein family/group databases
PeroxiBase	4602. SvAhpD.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_STRVD

Accession

Primary (citable) accession number: Q9X5V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	November 1, 1999
Last modified:	March 24, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)