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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-4931-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:MSMEG_4959, MSMEI_4832
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001515791 – 550Arginine--tRNA ligaseAdd BLAST550

Proteomic databases

PRIDEiQ9X5M0

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_4959

Structurei

3D structure databases

ProteinModelPortaliQ9X5M0
SMRiQ9X5M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 140"HIGH" regionAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247214
KOiK01887
OMAiNKPLHLG
OrthoDBiPOG091H01RF

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X5M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPADLAELL KATAAAVLTE HDLDVAALPA TVTVERPRNP EHGDYATNLA
60 70 80 90 100
LQLGKKVGVN PRELAGWLAT ALTAADGIAV AEVAGPGFVN LRIEASAQGV
110 120 130 140 150
IITNVLAAEG SYGSSDQYAG RNVNLEFVSA NPTGPIHIGG TRWAAVGDAL
160 170 180 190 200
GRLLATQGAA VTREYYFNDH GAQIDRFVNS LIASAKGEPT PEDGYAGDYI
210 220 230 240 250
VDIAQQVIAK APDVLGLPED QQRETFRAIG VDLMFTHIKQ SLHDFGTDFD
260 270 280 290 300
VYTHEDSMHT SGRVDQAITQ LREAGSIYEK DGAVWLRTTD FGDDKDRVVI
310 320 330 340 350
KSDGNAAYIA GDLAYYLDKR KRGFDLCIYM LGADHHGYIA RLKAAAAALG
360 370 380 390 400
DDPDTVEVLI GQMVNLVRDG QPVRMSKRAG TVITLDDLVE AIGVDAARYA
410 420 430 440 450
LIRSSVDTPI DIDLELWSSA SNENPVYYVQ YAHARLCALA RNAADLGVSV
460 470 480 490 500
NTDHLDLLTH EKEGALIRNL GEFPRVLKTA ASLREPHRVC RYLEDLAGDY
510 520 530 540 550
HRFYDSCRVL PQGDEEPGDL HSARLALCRA TRQVIANGLA ILGVSAPERM
Length:550
Mass (Da):59,429
Last modified:July 10, 2007 - v2
Checksum:i4DAB7844FFFCFCEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149A → T in AAD32590 (Ref. 1) Curated1
Sequence conflicti232D → N in AAD32590 (Ref. 1) Curated1
Sequence conflicti255 – 257EDS → GDW in AAD32590 (Ref. 1) Curated3
Sequence conflicti331L → V in AAD32590 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126720 Genomic DNA Translation: AAD32590.1
CP000480 Genomic DNA Translation: ABK70921.1
CP001663 Genomic DNA Translation: AFP41277.1
RefSeqiWP_011730214.1, NZ_CP009494.1
YP_889211.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK70921; ABK70921; MSMEG_4959
AFP41277; AFP41277; MSMEI_4832
GeneIDi4534266
KEGGimsb:LJ00_24520
msg:MSMEI_4832
msm:MSMEG_4959
PATRICifig|246196.19.peg.4838

Similar proteinsi

Entry informationi

Entry nameiSYR_MYCS2
AccessioniPrimary (citable) accession number: Q9X5M0
Secondary accession number(s): A0R223, I7G6F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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