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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:PA0336
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0336.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000570171 – 159RNA pyrophosphohydrolaseAdd BLAST159

Proteomic databases

PaxDbiQ9X4P2.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0336.

Structurei

3D structure databases

ProteinModelPortaliQ9X4P2.
SMRiQ9X4P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 149Nudix hydrolaseUniRule annotationAdd BLAST144

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
InParanoidiQ9X4P2.
KOiK08311.
OMAiQNAWQFP.
PhylomeDBiQ9X4P2.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X4P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDSDGFRPN VGIILANEAG QVLWARRINQ EAWQFPQGGI NDRETPEEAL
60 70 80 90 100
YRELNEEVGL EAGDVRILAC TRGWLRYRLP QRLVRTHSQP LCIGQKQKWF
110 120 130 140 150
LLRLMSDEAR VRMDITSKPE FDGWRWVSYW YPLGQVVTFK REVYRRALKE

LAPRLLARD
Length:159
Mass (Da):18,759
Last modified:November 1, 1999 - v1
Checksum:i05E119F7B82FCBE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116285 Genomic DNA. Translation: AAD22458.1.
AE004091 Genomic DNA. Translation: AAG03725.1.
PIRiC83604.
RefSeqiNP_249027.1. NC_002516.2.
WP_003084400.1. NZ_ASJY01000068.1.

Genome annotation databases

EnsemblBacteriaiAAG03725; AAG03725; PA0336.
GeneIDi882290.
KEGGipae:PA0336.
PATRICi19834906. VBIPseAer58763_0354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116285 Genomic DNA. Translation: AAD22458.1.
AE004091 Genomic DNA. Translation: AAG03725.1.
PIRiC83604.
RefSeqiNP_249027.1. NC_002516.2.
WP_003084400.1. NZ_ASJY01000068.1.

3D structure databases

ProteinModelPortaliQ9X4P2.
SMRiQ9X4P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0336.

Proteomic databases

PaxDbiQ9X4P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03725; AAG03725; PA0336.
GeneIDi882290.
KEGGipae:PA0336.
PATRICi19834906. VBIPseAer58763_0354.

Organism-specific databases

PseudoCAPiPA0336.

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
InParanoidiQ9X4P2.
KOiK08311.
OMAiQNAWQFP.
PhylomeDBiQ9X4P2.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPPH_PSEAE
AccessioniPrimary (citable) accession number: Q9X4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.