Reviewed, UniProtKB/Swiss-Prot Q9X4M1 (ACKA1_LACSS)

Names and origin

Protein names

Recommended name:
    Acetate kinase 1
    EC=2.7.2.1
Alternative name(s):
    Acetokinase 1

Gene names

Name:	ackA1
Synonyms:	ack1, ackA
Ordered Locus Names:	LCA_0198

Organism

Lactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]

Taxonomic identifier

314315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Acetate kinase 1 HAMAP MF_00020		PRO_0000107572

Sequences

	Sequence		Length	Mass (Da)
	Q9X4M1-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: D461B493C9F4B824	FASTA	394	42,993
	10 20 30 40 50 60 MEKILAINAG SSTLKWQLFE MPSETVIAKG MIDRLGLSDS VFTAKYGDNQ KFKEVQDVTT 70 80 90 100 110 120 HEMAATLLLT RLKELGIVSH LDEITGVGHR VVGGGEAFSD SMVINPVALD EINRLAEYAP 130 140 150 160 170 180 LHNPTQAYYI KIFTALLPGV PQVAVFDTSF YSTLAPENYL YSIPQEYYQT FGARKYGAHG 190 200 210 220 230 240 TSHRYVAHRA AEILGTPLES QKMITLHLGS GASITAVQDG HAVDTSMGFT PLAGITMGTR 250 260 270 280 290 300 SGDIDVSLVA FLAKKLEITM PEMIDILNHK SGLLGISELS PDMRDLEETA ATRPQSALAL 310 320 330 340 350 360 SIFVNRVVKY VGSYVALMNG IDTLVFTAGS GENGSELRAD ICKQLACFGV KLDEEKNNVR 370 380 390 SQERIISADD SKVKVLIVPT NEELMIARDV MRLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ribose utilization in Lactobacillus sakei: analysis of the regulation of the rbs operon and putative involvement of a new transporter." Stentz R., Zagorec M. J. Mol. Microbiol. Biotechnol. 1:165-173(1999) [PubMed: 10941799] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K." Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M. Nat. Biotechnol. 23:1527-1533(2005) [PubMed: 16273110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF115391 Genomic DNA. Translation: AAD34334.1. CR936503 Genomic DNA. Translation: CAI54495.1.
RefSeq	YP_394807.1.
3D structure databases
SMR	Q9X4M1. Positions 3-393.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9X4M1.
Genome annotation databases
GeneID	3777622.
GenomeReviews	Gene locus LCA_0198 in contig CR936503_GR.
KEGG	lsa:LSA0198.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	FGARKYG.
PhylomeDB	Q9X4M1.
Enzyme and pathway databases
BioCyc	LSAK314315:LSA0198-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA1_LACSS

Accession

Primary (citable) accession number: Q9X4M1
Secondary accession number(s): Q38Z82

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)