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Q9X4K8

- MDH_GEOTD

UniProt

Q9X4K8 - MDH_GEOTD

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Protein
Malate dehydrogenase
Gene
mdh
Organism
Geobacillus thermodenitrificans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NAD By similarity
Binding sitei87 – 871Substrate By similarity
Binding sitei93 – 931Substrate By similarity
Binding sitei100 – 1001NAD By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei156 – 1561Substrate By similarity
Active sitei180 – 1801Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD By similarity
Nucleotide bindingi123 – 1253NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiGeobacillus thermodenitrificans
Taxonomic identifieri33940 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Malate dehydrogenaseUniRule annotation
PRO_0000113435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9X4K8.
SMRiQ9X4K8. Positions 5-308.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X4K8-1 [UniParc]FASTAAdd to Basket

« Hide

MAMKRKKISV IGAGFTGATT AFLLAQKELG DIVLVDIPQL ENPTKGKALD    50
MLESSPVLGF DANIVGTSDY ADTADSDIVV ITAGIARKPG MSRDDLVTTN 100
QKIMKQVTKE VVKYSPNCYI IVLTNPVDAM SYTVFKESGF PKNRVIGQSG 150
VLDTARFRTF VAQELNISVK DVTGFVLGGH GDDMVPLVRY SYAGGIPLEK 200
LIPKDRLDAI VERTRKGGGE IVNLLGNGSA YYAPAASLAE MVEAIVKDQR 250
RILPAITYLE GEYGYEGIYL GVPTILGGNG IEKVIELELT EDEKAALAKS 300
LESVKNVMRV LE 312
Length:312
Mass (Da):33,682
Last modified:November 1, 1999 - v1
Checksum:i68C691C462EFF452
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF114423 Genomic DNA. Translation: AAD28555.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF114423 Genomic DNA. Translation: AAD28555.1 .

3D structure databases

ProteinModelPortali Q9X4K8.
SMRi Q9X4K8. Positions 5-308.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Properties and primary structure of a thermostable L-malate dehydrogenase from 'Bacillus thermodenitrificans'."
    Williams R.A.D., Welch S.G., Alawadhi S.A.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 00462.

Entry informationi

Entry nameiMDH_GEOTD
AccessioniPrimary (citable) accession number: Q9X4K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi