Q9X4K7 (Q9X4K7_STRCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Propionyl-CoA carboxylase complex B subunit EMBL AAD28194.1

Gene names

Name:	pccB EMBL AAD28194.1
Ordered Locus Names:	SCO4926

Organism

Streptomyces coelicolor EMBL AAD28194.1

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Biotin PDB 1XNY PDB 3IB9
Technical term	3D-structure PDB 1XNY PDB 3IAV PDB 1XNW PDB 3IBB PDB 3IB9 PDB 3MFM PDB 1XNV PDB 1XO6 Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	acetyl-CoA carboxylase complex Inferred from electronic annotation. Source: InterPro
Molecular function	acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	377 – 379	3	Biotin 2 binding PDB 1XNY
	Region	417 – 420	4	Biotin 2 binding PDB 1XNY
Sites
	Binding site	43	1	Biotin 1 PDB 3IB9
	Binding site	202	1	Biotin 1 PDB 3IB9
	Binding site	221	1	Biotin 1 PDB 3IB9

Sequences

	Sequence		Length	Mass (Da)
	Q9X4K7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3CD6380087CFA431	FASTA	530	57,159
	10 20 30 40 50 60 MSEPEEQQPD IHTTAGKLAD LRRRIEEATH AGSARAVEKQ HAKGKLTARE RIDLLLDEGS 70 80 90 100 110 120 FVELDEFARH RSTNFGLDAN RPYGDGVVTG YGTVDGRPVA VFSQDFTVFG GALGEVYGQK 130 140 150 160 170 180 IVKVMDFALK TGCPVVGIND SGGARIQEGV ASLGAYGEIF RRNTHASGVI PQISLVVGPC 190 200 210 220 230 240 AGGAVYSPAI TDFTVMVDQT SHMFITGPDV IKTVTGEDVG FEELGGARTH NSTSGVAHHM 250 260 270 280 290 300 AGDEKDAVEY VKQLLSYLPS NNLSEPPAFP EEADLAVTDE DAELDTIVPD SANQPYDMHS 310 320 330 340 350 360 VIEHVLDDAE FFETQPLFAP NILTGFGRVE GRPVGIVANQ PMQFAGCLDI TASEKAARFV 370 380 390 400 410 420 RTCDAFNVPV LTFVDVPGFL PGVDQEHDGI IRRGAKLIFA YAEATVPLIT VITRKAFGGA 430 440 450 460 470 480 YDVMGSKHLG ADLNLAWPTA QIAVMGAQGA VNILHRRTIA DAGDDAEATR ARLIQEYEDA 490 500 510 520 530 LLNPYTAAER GYVDAVIMPS DTRRHIVRGL RQLRTKRESL PPKKHGNIPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.
[2]	"Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)." Rodriguez E., Gramajo H. Microbiology 145:3109-3119(1999) [PubMed: 10589718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A3 EMBL AAD28194.1.
[3]	"Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor." Arabolaza A., Shillito M.E., Lin T.W., Diacovich L., Melgar M., Pham H., Amick D., Gramajo H., Tsai S.C. Biochemistry 49:7367-7376(2010) [PubMed: 20690600] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH BIOTIN.
[4]	"Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity." Diacovich L., Mitchell D.L., Pham H., Gago G., Melgar M.M., Khosla C., Gramajo H., Tsai S.C. Biochemistry 43:14027-14036(2004) [PubMed: 15518551] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH BIOTIN.
[5]	Gramajo H.C., Rodriguez E.J., Danchin A. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A3 EMBL AAD28194.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF113605 Genomic DNA. Translation: AAD28194.1.
AL939121 Genomic DNA. Translation: CAD30916.1.

PIR

T42208.

RefSeq

NP_629079.1. NC_003888.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XNV	X-ray	2.30	A/B	1-530	[»]
1XNW	X-ray	2.60	A/B/C/D/E/F	1-530	[»]
1XNY	X-ray	2.20	A/B	1-530	[»]
1XO6	X-ray	2.20	A/B/C/D/E/F	1-530	[»]
3IAV	X-ray	1.75	A/B	1-530	[»]
3IB9	X-ray	2.00	A/B	1-530	[»]
3IBB	X-ray	3.50	A/B/C/D/E/F	1-530	[»]
3MFM	X-ray	2.38	A/B/C/D/E/F	1-530	[»]

ProteinModelPortal

Q9X4K7.

SMR

Q9X4K7. Positions 10-530.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1100367.

GenomeReviews

Gene locus SCO4926 in contig AL645882_GR.

KEGG

sco:SCO4926.

NMPDR

fig|100226.1.peg.4881.

PATRIC

23739690. VBIStrCoe124346_5005.

Phylogenomic databases

HOGENOM

HBG461319.

OMA

YQAAELG.

PhylomeDB

Q9X4K7.

ProtClustDB

CLSK636053.

Family and domain databases

InterPro

IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]

KO

K01966.

Pfam

PF01039. Carboxyl_trans. 1 hit.
[Graphical view]

PRINTS

PR01070. ACCCTRFRASEB.

PROSITE

PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9X4K7_STRCO

Accession

Primary (citable) accession number: Q9X4K7

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)