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Q9X4K7

- Q9X4K7_STRCH

UniProt

Q9X4K7 - Q9X4K7_STRCH

Protein
Submitted name:

Propionyl-CoA carboxylase complex B subunit

Gene

pccB

Organism
Streptomyces coelicolor
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431Biotin 1
    Binding sitei74 – 741Sulfate 3
    Binding sitei182 – 1821Substrate; via amide nitrogenImported
    Binding sitei183 – 1831Substrate; via amide nitrogenImported
    Binding sitei202 – 2021Biotin 1
    Binding sitei202 – 2021Biotin 2
    Binding sitei221 – 2211Biotin 1
    Binding sitei221 – 2211Biotin 2
    Sitei419 – 4191Important for catalytic activity; via amide nitrogenImported
    Sitei420 – 4201Important for catalytic activity; via amide nitrogenImported
    Binding sitei490 – 4901Sulfate 3

    GO - Molecular functioni

    1. acetyl-CoA carboxylase activity Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: InterPro

    Keywords - Ligandi

    BiotinImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Propionyl-CoA carboxylase complex B subunitImported
    Gene namesi
    Name:pccBImported
    OrganismiStreptomyces coelicolorImported
    Taxonomic identifieri1902 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

    Subcellular locationi

    GO - Cellular componenti

    1. acetyl-CoA carboxylase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO4926.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XNVX-ray2.30A/B1-530[»]
    1XNWX-ray2.60A/B/C/D/E/F1-530[»]
    1XNYX-ray2.20A/B1-530[»]
    1XO6X-ray2.20A/B/C/D/E/F1-530[»]
    3IAVX-ray1.75A/B1-530[»]
    3IB9X-ray2.00A/B1-530[»]
    3IBBX-ray3.50A/B/C/D/E/F1-530[»]
    3MFMX-ray2.38A/B/C/D/E/F1-530[»]
    ProteinModelPortaliQ9X4K7.
    SMRiQ9X4K7. Positions 10-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X4K7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni377 – 3793Biotin 4 bindingImported
    Regioni417 – 4204Biotin 4 bindingImported

    Phylogenomic databases

    HOGENOMiHOG000218693.
    KOiK01966.
    OrthoDBiEOG696BWK.
    PhylomeDBiQ9X4K7.

    Family and domain databases

    Gene3Di3.90.226.10. 2 hits.
    InterProiIPR000438. Acetyl_CoA_COase_Trfase_b_su.
    IPR000022. Carboxyl_trans.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR011762. COA_CT_N.
    [Graphical view]
    PfamiPF01039. Carboxyl_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01070. ACCCTRFRASEB.
    SUPFAMiSSF52096. SSF52096. 2 hits.
    PROSITEiPS50989. COA_CT_CTER. 1 hit.
    PS50980. COA_CT_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X4K7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEPEEQQPD IHTTAGKLAD LRRRIEEATH AGSARAVEKQ HAKGKLTARE    50
    RIDLLLDEGS FVELDEFARH RSTNFGLDAN RPYGDGVVTG YGTVDGRPVA 100
    VFSQDFTVFG GALGEVYGQK IVKVMDFALK TGCPVVGIND SGGARIQEGV 150
    ASLGAYGEIF RRNTHASGVI PQISLVVGPC AGGAVYSPAI TDFTVMVDQT 200
    SHMFITGPDV IKTVTGEDVG FEELGGARTH NSTSGVAHHM AGDEKDAVEY 250
    VKQLLSYLPS NNLSEPPAFP EEADLAVTDE DAELDTIVPD SANQPYDMHS 300
    VIEHVLDDAE FFETQPLFAP NILTGFGRVE GRPVGIVANQ PMQFAGCLDI 350
    TASEKAARFV RTCDAFNVPV LTFVDVPGFL PGVDQEHDGI IRRGAKLIFA 400
    YAEATVPLIT VITRKAFGGA YDVMGSKHLG ADLNLAWPTA QIAVMGAQGA 450
    VNILHRRTIA DAGDDAEATR ARLIQEYEDA LLNPYTAAER GYVDAVIMPS 500
    DTRRHIVRGL RQLRTKRESL PPKKHGNIPL 530
    Length:530
    Mass (Da):57,159
    Last modified:November 1, 1999 - v1
    Checksum:i3CD6380087CFA431
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113605 Genomic DNA. Translation: AAD28194.1.
    PIRiT42208.
    RefSeqiNP_629079.1. NC_003888.3.

    Genome annotation databases

    GeneIDi1100367.
    KEGGisco:SCO4926.
    PATRICi23739690. VBIStrCoe124346_5005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113605 Genomic DNA. Translation: AAD28194.1 .
    PIRi T42208.
    RefSeqi NP_629079.1. NC_003888.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XNV X-ray 2.30 A/B 1-530 [» ]
    1XNW X-ray 2.60 A/B/C/D/E/F 1-530 [» ]
    1XNY X-ray 2.20 A/B 1-530 [» ]
    1XO6 X-ray 2.20 A/B/C/D/E/F 1-530 [» ]
    3IAV X-ray 1.75 A/B 1-530 [» ]
    3IB9 X-ray 2.00 A/B 1-530 [» ]
    3IBB X-ray 3.50 A/B/C/D/E/F 1-530 [» ]
    3MFM X-ray 2.38 A/B/C/D/E/F 1-530 [» ]
    ProteinModelPortali Q9X4K7.
    SMRi Q9X4K7. Positions 10-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO4926.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1100367.
    KEGGi sco:SCO4926.
    PATRICi 23739690. VBIStrCoe124346_5005.

    Phylogenomic databases

    HOGENOMi HOG000218693.
    KOi K01966.
    OrthoDBi EOG696BWK.
    PhylomeDBi Q9X4K7.

    Miscellaneous databases

    EvolutionaryTracei Q9X4K7.

    Family and domain databases

    Gene3Di 3.90.226.10. 2 hits.
    InterProi IPR000438. Acetyl_CoA_COase_Trfase_b_su.
    IPR000022. Carboxyl_trans.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR011762. COA_CT_N.
    [Graphical view ]
    Pfami PF01039. Carboxyl_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01070. ACCCTRFRASEB.
    SUPFAMi SSF52096. SSF52096. 2 hits.
    PROSITEi PS50989. COA_CT_CTER. 1 hit.
    PS50980. COA_CT_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Gramajo H.C., Rodriguez E.J., Danchin A.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A3Imported.
    2. "Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)."
      Rodriguez E., Gramajo H.
      Microbiology 145:3109-3119(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A3Imported.
    3. "Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity."
      Diacovich L., Mitchell D.L., Pham H., Gago G., Melgar M.M., Khosla C., Gramajo H., Tsai S.C.
      Biochemistry 43:14027-14036(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH BIOTIN, ACTIVE SITE.
    4. "Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor."
      Arabolaza A., Shillito M.E., Lin T.W., Diacovich L., Melgar M., Pham H., Amick D., Gramajo H., Tsai S.C.
      Biochemistry 49:7367-7376(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH BIOTIN.

    Entry informationi

    Entry nameiQ9X4K7_STRCH
    AccessioniPrimary (citable) accession number: Q9X4K7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3