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Q9X4G0

- HGD_PSEAE

UniProt

Q9X4G0 - HGD_PSEAE

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871Proton acceptorUniRule annotation
Metal bindingi330 – 3301IronUniRule annotation
Metal bindingi336 – 3361IronUniRule annotation
Binding sitei345 – 3451homogentisateUniRule annotation
Metal bindingi366 – 3661IronUniRule annotation
Binding sitei366 – 3661homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:PA2009
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA2009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Homogentisate 1,2-dioxygenasePRO_0000220249Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA2009.

Structurei

3D structure databases

ProteinModelPortaliQ9X4G0.
SMRiQ9X4G0. Positions 8-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ9X4G0.
KOiK00451.
OMAiTTETHKL.
OrthoDBiEOG6D5FZK.
PhylomeDBiQ9X4G0.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X4G0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLDSTALAY QSGFGNEFSS EALPGALPVG QNSPQKAPYG LYAELLSGTA
60 70 80 90 100
FTMARSEARR TWLYRITPSA KHPPFRRLER QIAGAELDAP TPNRLRWDPL
110 120 130 140 150
ALPEQPTDFL DGLLRMAANA PGDKPAGVSI YQYLANRSME RCFYDADGEL
160 170 180 190 200
LLVPQLGRLR LCTELGALQV EPLEIAVIPR GMKFRVELLD GEARGYIAEN
210 220 230 240 250
HGAPLRLPDL GPIGSNGLAN PRDFLTPVAR YEDSRQPLQL VQKYLGELWA
260 270 280 290 300
CELDHSPLDV VAWHGNNVPY KYDLRRFNTI GTVSFDHPDP SIFTVLTSPT
310 320 330 340 350
SVPGLANIDF VIFPPRWMVA ENTFRPPWFH RNLMNEFMGL IQGAYDAKAG
360 370 380 390 400
GFVPGGASLH SCMSAHGPDA ESCDKAIAAD LKPHRIDQTM AFMFETSQVL
410 420 430
RPSRAALETP ALQNDYDACW ASLVSTFNPQ RR
Length:432
Mass (Da):47,841
Last modified:December 8, 2000 - v2
Checksum:i44B17EC2A0811E2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05397.1.
AF109214 Genomic DNA. Translation: AAD23385.1.
PIRiF83394.
RefSeqiNP_250699.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG05397; AAG05397; PA2009.
GeneIDi877745.
KEGGipae:PA2009.
PATRICi19838425. VBIPseAer58763_2093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004091 Genomic DNA. Translation: AAG05397.1 .
AF109214 Genomic DNA. Translation: AAD23385.1 .
PIRi F83394.
RefSeqi NP_250699.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9X4G0.
SMRi Q9X4G0. Positions 8-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA2009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG05397 ; AAG05397 ; PA2009 .
GeneIDi 877745.
KEGGi pae:PA2009.
PATRICi 19838425. VBIPseAer58763_2093.

Organism-specific databases

PseudoCAPi PA2009.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
InParanoidi Q9X4G0.
KOi K00451.
OMAi TTETHKL.
OrthoDBi EOG6D5FZK.
PhylomeDBi Q9X4G0.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. "Genes encoding phenylalanine catabolism in Pseudomonas aeruginosa."
    Beatson S.A., Whitchurch C.B., Mattick J.S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-236.
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiHGD_PSEAE
AccessioniPrimary (citable) accession number: Q9X4G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 8, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3