Reviewed,
UniProtKB/Swiss-Prot Q9X4F5 (HGD_RHIME)
Last modified
November 4, 2008.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisicase Homogentisate oxygenase Homogentisic acid oxidase | ||||||
| Gene names |
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| Organism | Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 382 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium |
Protein attributes
| Sequence length | 453 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Homogentisate + O(2) = 4-maleylacetoacetate. |
| Cofactor | Iron By similarity. |
| Pathway | |
| Induction | By nitrogen and carbon deprivation as well as in the presence of tyrosine. Also induced by phenylalanine, but only in nitrogen-free medium. |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel nutrient-deprivation-induced Sinorhizobium meliloti gene (hmgA) involved in the degradation of tyrosine." Milcamps A., de Bruijn F.J. Microbiology 145:935-947(1999) [PubMed: 10220173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1021. |
| [2] | "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. Galibert F.Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021. |
Cross-references
Sequence databases | |
|---|---|
| AF109131 Genomic DNA. Translation: AAD29874.1. AL591688 Genomic DNA. Translation: CAC47518.1. | |
| RefSeq | NP_387045.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EYB based on UniProtKB Q93099. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1234616. |
| GenomeReviews | Gene locus R02939 in contig AL591688_GR. |
| KEGG | sme:SMc03208. |
| NMPDR | fig|266834.1.peg.4233. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9X4F5. |
Enzyme and pathway databases | |
| BioCyc | SMEL266834:SMC03208-MON. |
Family and domain databases | |
| HAMAP | MF_00334. [Tree] |
| InterPro | IPR005708. Homogentis_dOase. [Graphical view] |
| PANTHER | PTHR11056. Homogentis_dOase. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| BLOCKS | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | HGD_RHIME | ||||||||
| Accession | Primary (citable) accession number: Q9X4F5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


