Q9X4E3 (TRPF_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	trpF
Ordered Locus Names:	RHOS4_36220
ORF Names:	RSP_3587

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Reference proteome] [HAMAP]

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135		PRO_0000154375

Sequences

	Sequence		Length	Mass (Da)
	Q9X4E3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: DF2D9294D0D8ACAC	FASTA	212	22,142
	10 20 30 40 50 60 MAGVRVKICG LRTESDVKAA ASSGAAYVGL VFFPKSPRHL ELAQAQRLAL AAPPGVAKVA 70 80 90 100 110 120 LTVDASDETL DAIVEAVPLD MLQLHGGESP ERVAEVRARY GLPVMKAVGV ADEGDLPQIL 130 140 150 160 170 180 EQSLAADQIL IDAKPPKGAA LPGGNGLSFD WRLISGRHWI RPWMLAGGLT VENLAEAVRR 190 200 210 TGASQVDVSS GVESAPGVKD PARIAAFLQA AR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple chromosomes in bacteria. The yin and yang of trp gene localization in Rhodobacter sphaeroides 2.4.1." Mackenzie C., Simmons A.E., Kaplan S. Genetics 153:525-538(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 2 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF107093 Genomic DNA. Translation: AAD29259.1. CP000144 Genomic DNA. Translation: ABA81190.1.
RefSeq	YP_355091.1. NC_007494.1.
3D structure databases
ProteinModelPortal	Q9X4E3.
ModBase	Search...
Protein-protein interaction databases
STRING	272943.RSP_3587.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3722104.
KEGG	rsp:RSP_3587.
PATRIC	23157357. VBIRhoSph57909_4023.
Phylogenomic databases
eggNOG	COG0135.
HOGENOM	HOG000161598.
KO	K01817.
OMA	FVNASRC.
ProtClustDB	PRK01222.
Enzyme and pathway databases
BioCyc	RSPH272943:GJAS-3716-MONOMER.
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00135. PRAI.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_RHOS4

Accession

Primary (citable) accession number: Q9X4E3
Secondary accession number(s): Q3IW94

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program