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Protein

Replicative DNA helicase

Gene

dnaB

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • DNA binding Source: UniProtKB-UniRule
  • DNA helicase activity Source: UniProtKB-UniRule
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseUniRule annotationImported, Hydrolase
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replicative DNA helicaseUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:dnaBImported
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)Imported
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

PrimosomeUniRule annotation

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-48437N.
IntActiQ9X4C9. 3 interactors.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R6AX-ray2.90A/B1-454[»]
2R6CX-ray4.00A/B/C/D/E/F1-454[»]
2R6DX-ray3.70A/B/C/D/E/F1-454[»]
2R6EX-ray5.02A/B1-454[»]
4ESVX-ray3.20A/B/C/D/E/F/G/H/I/J/K/L1-454[»]
4M4WX-ray6.10A/B/C/D/E/F1-454[»]
ProteinModelPortaliQ9X4C9.
SMRiQ9X4C9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X4C9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 445SF4 helicaseInterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the helicase family. DnaB subfamily.UniRule annotation

Family and domain databases

CDDicd00984. DnaB_C. 1 hit.
Gene3Di1.10.860.10. 1 hit.
InterProiView protein in InterPro
IPR007692. DNA_helicase_DnaB.
IPR007694. DNA_helicase_DnaB-like_C.
IPR007693. DNA_helicase_DnaB-like_N.
IPR016136. DNA_helicase_N/primase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00772. DnaB. 1 hit.
PF03796. DnaB_C. 1 hit.
SUPFAMiSSF48024. SSF48024. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00665. DnaB. 1 hit.
PROSITEiView protein in PROSITE
PS51199. SF4_HELICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X4C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELFSERIP PQSIEAEQAV LGAVFLDPAA LVPASEILIP EDFYRAAHQK
60 70 80 90 100
IFHAMLRVAD RGEPVDLVTV TAELAASEQL EEIGGVSYLS ELADAVPTAA
110 120 130 140 150
NVEYYARIVE EKSVLRRLIR TATSIAQDGY TREDEIDVLL DEADRKIMEV
160 170 180 190 200
SQRKHSGAFK NIKDILVQTY DNIEMLHNRD GEITGIPTGF TELDRMTSGF
210 220 230 240 250
QRSDLIIVAA RPSVGKTAFA LNIAQNVATK TNENVAIFSL EMSAQQLVMR
260 270 280 290 300
MLCAEGNINA QNLRTGKLTP EDWGKLTMAM GSLSNAGIYI DDTPSIRVSD
310 320 330 340 350
IRAKCRRLKQ ESGLGMIVID YLQLIQGSGR SKENRQQEVS EISRSLKALA
360 370 380 390 400
RELEVPVIAL SQLSRSVEQR QDKRPMMSDI RESGSIEQDA DIVAFLYRDD
410 420 430 440 450
YYNKDSENKN IIEIIIAKQR NGPVGTVQLA FIKEYNKFVN LERRFDEAQI

PPGA
Length:454
Mass (Da):50,643
Last modified:November 1, 1999 - v1
Checksum:iD6115B868E11BAC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106032 Genomic DNA. Translation: AAD20314.1.

Similar proteinsi

Entry informationi

Entry nameiQ9X4C9_GEOSE
AccessioniPrimary (citable) accession number: Q9X4C9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources