Reviewed, UniProtKB/Swiss-Prot Q9X450 (FABI_RHIME)

Names and origin

Protein names

Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase

Gene names

Name:

fabI

Organism

Rhizobium meliloti (Sinorhizobium meliloti)

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	55 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›55	›55	Enoyl-[acyl-carrier-protein] reductase [NADH]		PRO_0000054907
Regions
	Nucleotide binding	17 – 43	27	NAD By similarity
Experimental info
	Non-terminal residue	55	1

Sequences

	Sequence		Length	Mass (Da)
	Q9X450-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0FC6A58A8F0C3C50	FASTA	55	5,905
	10 20 30 40 50 MSIPTVKAKL LQGRKGLIVG IANDRSIAWG RARAFRALGA EIAVTYLNDK ALPLV

References

[1]

"Genes coding for phosphotransacetylase and acetate kinase in Sinorhizobium meliloti are in an operon that is inducible by phosphate stress and controlled by phoB." Summers M.L., Denton M.C., McDermott T.R. J. Bacteriol. 181:2217-2224(1999) [PubMed: 10094701] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 104A14.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF095903 Genomic DNA. Translation: AAD24359.1.
3D structure databases
HSSP	HSSP built from PDB template 1QSG based on UniProtKB P29132.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.1.9. 142.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABI_RHIME

Accession

Primary (citable) accession number: Q9X450

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)