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Protein

Redox-sensing transcriptional repressor Rex

Gene

rex

Organism
Thermus aquaticus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Modulates transcription in response to changes in cellular NADH/NAD+ redox state.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 52H-T-H motifUniRule annotationAdd BLAST40
Nucleotide bindingi87 – 92NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Redox-sensing transcriptional repressor RexUniRule annotation
Gene namesi
Name:rexUniRule annotation
OrganismiThermus aquaticus
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000979251 – 211Redox-sensing transcriptional repressor RexAdd BLAST211

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

DIPiDIP-48428N.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 21Combined sources17
Turni22 – 25Combined sources4
Helixi31 – 38Combined sources8
Helixi42 – 50Combined sources9
Helixi64 – 74Combined sources11
Turni75 – 78Combined sources4
Beta strandi81 – 87Combined sources7
Helixi90 – 95Combined sources6
Beta strandi103 – 111Combined sources9
Turni115 – 119Combined sources5
Beta strandi123 – 128Combined sources6
Beta strandi130 – 132Combined sources3
Helixi133 – 135Combined sources3
Turni138 – 140Combined sources3
Beta strandi143 – 146Combined sources4
Helixi150 – 162Combined sources13
Beta strandi166 – 170Combined sources5
Beta strandi172 – 174Combined sources3
Beta strandi182 – 186Combined sources5
Turni189 – 192Combined sources4
Helixi193 – 201Combined sources9
Turni203 – 205Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XCBX-ray2.90A/B/C/D/E/F/G1-211[»]
ProteinModelPortaliQ9X2V5.
SMRiQ9X2V5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2V5.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory Rex family.UniRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01131. Rex. 1 hit.
InterProiIPR003781. CoA-bd.
IPR016040. NAD(P)-bd_dom.
IPR009718. Rex_DNA-bd_C_dom.
IPR022876. Tscrpt_rep_Rex.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF06971. Put_DNA-bind_N. 1 hit.
[Graphical view]
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X2V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVPEAAISR LITYLRILEE LEAQGVHRTS SEQLGELAQV TAFQVRKDLS
60 70 80 90 100
YFGSYGTRGV GYTVPVLKRE LRHILGLNRK WGLCIVGMGR LGSALADYPG
110 120 130 140 150
FGESFELRGF FDVDPEKVGR PVRGGVIEHV DLLPQRVPGR IEIALLTVPR
160 170 180 190 200
EAAQKAADLL VAAGIKGILN FAPVVLEVPK EVAVENVDFL AGLTRLSFAI
210
LNPKWREEMM G
Length:211
Mass (Da):23,222
Last modified:November 1, 1999 - v1
Checksum:iA49C2755DDB1D7EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061257 Genomic DNA. Translation: AAD22519.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061257 Genomic DNA. Translation: AAD22519.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XCBX-ray2.90A/B/C/D/E/F/G1-211[»]
ProteinModelPortaliQ9X2V5.
SMRiQ9X2V5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48428N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2V5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01131. Rex. 1 hit.
InterProiIPR003781. CoA-bd.
IPR016040. NAD(P)-bd_dom.
IPR009718. Rex_DNA-bd_C_dom.
IPR022876. Tscrpt_rep_Rex.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF06971. Put_DNA-bind_N. 1 hit.
[Graphical view]
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiREX_THEAQ
AccessioniPrimary (citable) accession number: Q9X2V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.