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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.1.31. 5087.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:PA3182
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901021 – 2386-phosphogluconolactonaseAdd BLAST238

Proteomic databases

PaxDbiQ9X2N2.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3182.

Structurei

3D structure databases

ProteinModelPortaliQ9X2N2.
SMRiQ9X2N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108Q79. Bacteria.
COG0363. LUCA.
HOGENOMiHOG000256284.
InParanoidiQ9X2N2.
KOiK01057.
OMAiKQPHLAI.
PhylomeDBiQ9X2N2.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X2N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISELKLPA GVGLQVWGSA AEQARGLAAE VAGRLRSALA EQGQALLVVS
60 70 80 90 100
GGRSPVAFLE ALSEEPLDWS RITVSLADER WVPESHADSN AGLVRRHLLR
110 120 130 140 150
GEAAKARFIG LYQPAASLEE AAELADHHLH ELPLPIDVLV LGMGDDGHTA
160 170 180 190 200
SLFPNSPGLD LAMDPQGTRR CLPMWAPSVP HQRLTLPRAV LAAAKVQLLA
210 220 230
IQGQSKLATL NAALAVEDER RMPVRAFLRA PLTIHWYP
Length:238
Mass (Da):25,571
Last modified:May 30, 2000 - v2
Checksum:iEECE335BBE904F46
GO

Sequence cautioni

The sequence AAD22666 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029673 Genomic DNA. Translation: AAD22666.1. Different initiation.
AE004091 Genomic DNA. Translation: AAG06570.1.
PIRiH83247.
RefSeqiNP_251872.1. NC_002516.2.
WP_003113441.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06570; AAG06570; PA3182.
GeneIDi882680.
KEGGipae:PA3182.
PATRICi19840931. VBIPseAer58763_3326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029673 Genomic DNA. Translation: AAD22666.1. Different initiation.
AE004091 Genomic DNA. Translation: AAG06570.1.
PIRiH83247.
RefSeqiNP_251872.1. NC_002516.2.
WP_003113441.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9X2N2.
SMRiQ9X2N2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3182.

Proteomic databases

PaxDbiQ9X2N2.

Protocols and materials databases

DNASUi882680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06570; AAG06570; PA3182.
GeneIDi882680.
KEGGipae:PA3182.
PATRICi19840931. VBIPseAer58763_3326.

Organism-specific databases

PseudoCAPiPA3182.

Phylogenomic databases

eggNOGiENOG4108Q79. Bacteria.
COG0363. LUCA.
HOGENOMiHOG000256284.
InParanoidiQ9X2N2.
KOiK01057.
OMAiKQPHLAI.
PhylomeDBiQ9X2N2.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BRENDAi3.1.1.31. 5087.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_PSEAE
AccessioniPrimary (citable) accession number: Q9X2N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.