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Q9X2M2 (BETA_STAXY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Synonyms:cudB
OrganismStaphylococcus xylosus
Taxonomic identifier1288 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205605

Regions

Nucleotide binding6 – 3530FAD By similarity

Sites

Active site4721 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9X2M2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 4D8395EED9E584D7

FASTA56062,384
        10         20         30         40         50         60 
MKESYDYIII GGGSAGSVLG GRLSEDVSNN VLVLEAGRSD YPWDLLIQMP AALMYPAGNK 

        70         80         90        100        110        120 
LYDWIYETTP EPHMDGRKVG HARGKVLGGS SSINGMIYQR GNPMDYEKWA KPEGMESWDY 

       130        140        150        160        170        180 
AHCLPYFKRL ETTFGSKKGD PYRGHHGPIK LRRGPADNPL FQAFFDAGVE AGYNKTPDVN 

       190        200        210        220        230        240 
GFRQEGFGPF DSQVHNGRRV SASRAYLHPA MKRKNLEVQT RAFVTKLNFE GNKVTGVTFK 

       250        260        270        280        290        300 
KNGKEHTESA KEVILSGGAI NSPQLLQLSG IGDSEHLRSL GIEPRIHLPG VGENFEDHLE 

       310        320        330        340        350        360 
VYVQHACKQP VSMQPSLNKL KMPFIGLQWI LGRKGAAASN HFEGGGFVRS NDDVDYPNLM 

       370        380        390        400        410        420 
FHFLPIAVRY DGTKAPAAHG YQVHVGPMYS NSRGHLKIKS KDPFEKPEFV FNYLSTEEDK 

       430        440        450        460        470        480 
REWVEAIKVA RNILKQKALD PFNGGEISPG PEVQTDEEII EWVKRDGETA LHPSCSCRMG 

       490        500        510        520        530        540 
PASDEMSVVD PETFKVHGME NLRVVDASVM PRTTNGNIHS PVLMMAERAS DIIRGKKPLD 

       550        560 
PQYIDFYRHG VHDKDAGTVK 

« Hide

References

[1]"The choline-converting pathway in Staphylococcus xylosus C2A: genetic and physiological characterization."
Rosenstein R., Futter-Bryniok D., Gotz F.
J. Bacteriol. 181:2273-2278(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 20267 / Isolate C2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF009415 Genomic DNA. Translation: AAD23901.1.

3D structure databases

ProteinModelPortalQ9X2M2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_STAXY
AccessionPrimary (citable) accession number: Q9X2M2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways