Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Staphylococcus xylosus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei472Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 35FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Synonyms:cudB
OrganismiStaphylococcus xylosus
Taxonomic identifieri1288 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056051 – 560Oxygen-dependent choline dehydrogenaseAdd BLAST560

Structurei

3D structure databases

ProteinModelPortaliQ9X2M2
SMRiQ9X2M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Family and domain databases

Gene3Di3.50.50.604 hits
4.10.450.102 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X2M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESYDYIII GGGSAGSVLG GRLSEDVSNN VLVLEAGRSD YPWDLLIQMP
60 70 80 90 100
AALMYPAGNK LYDWIYETTP EPHMDGRKVG HARGKVLGGS SSINGMIYQR
110 120 130 140 150
GNPMDYEKWA KPEGMESWDY AHCLPYFKRL ETTFGSKKGD PYRGHHGPIK
160 170 180 190 200
LRRGPADNPL FQAFFDAGVE AGYNKTPDVN GFRQEGFGPF DSQVHNGRRV
210 220 230 240 250
SASRAYLHPA MKRKNLEVQT RAFVTKLNFE GNKVTGVTFK KNGKEHTESA
260 270 280 290 300
KEVILSGGAI NSPQLLQLSG IGDSEHLRSL GIEPRIHLPG VGENFEDHLE
310 320 330 340 350
VYVQHACKQP VSMQPSLNKL KMPFIGLQWI LGRKGAAASN HFEGGGFVRS
360 370 380 390 400
NDDVDYPNLM FHFLPIAVRY DGTKAPAAHG YQVHVGPMYS NSRGHLKIKS
410 420 430 440 450
KDPFEKPEFV FNYLSTEEDK REWVEAIKVA RNILKQKALD PFNGGEISPG
460 470 480 490 500
PEVQTDEEII EWVKRDGETA LHPSCSCRMG PASDEMSVVD PETFKVHGME
510 520 530 540 550
NLRVVDASVM PRTTNGNIHS PVLMMAERAS DIIRGKKPLD PQYIDFYRHG
560
VHDKDAGTVK
Length:560
Mass (Da):62,384
Last modified:November 1, 1999 - v1
Checksum:i4D8395EED9E584D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009415 Genomic DNA Translation: AAD23901.1

Similar proteinsi

Entry informationi

Entry nameiBETA_STAXY
AccessioniPrimary (citable) accession number: Q9X2M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program