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Q9X2I8

- SYE2_THEMA

UniProt

Q9X2I8 - SYE2_THEMA

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Protein

Glutamate--tRNA ligase 2

Gene
gltX2, TM_1875
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei257 – 2571ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1926-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2 (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase 2
Short name:
GluRS 2
Gene namesi
Name:gltX2
Ordered Locus Names:TM_1875
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Glutamate--tRNA ligase 2UniRule annotationPRO_0000119681Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-59231N.
STRINGi243274.TM1875.

Structurei

Secondary structure

1
487
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 294
Beta strandi34 – 363
Helixi39 – 5517
Beta strandi58 – 614
Turni68 – 703
Helixi73 – 8513
Beta strandi91 – 933
Turni94 – 963
Helixi105 – 1073
Helixi109 – 12113
Beta strandi124 – 1307
Beta strandi132 – 1343
Beta strandi137 – 1448
Helixi147 – 1515
Beta strandi156 – 1605
Beta strandi164 – 1718
Turni172 – 1743
Beta strandi175 – 1806
Helixi181 – 1833
Beta strandi187 – 1904
Turni192 – 1943
Helixi198 – 20811
Beta strandi212 – 2176
Helixi218 – 2236
Helixi224 – 23411
Beta strandi240 – 2445
Beta strandi252 – 2543
Turni257 – 2593
Beta strandi261 – 2633
Helixi264 – 2707
Helixi274 – 28310
Helixi296 – 2994
Helixi300 – 3023
Helixi305 – 3073
Helixi317 – 33014
Helixi333 – 34715
Helixi356 – 36611
Turni367 – 3693
Helixi373 – 38412
Helixi392 – 3976
Turni398 – 4003
Helixi404 – 41613
Helixi423 – 43513
Helixi441 – 45313
Beta strandi454 – 4574
Helixi461 – 4688
Helixi470 – 48415

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AFHX-ray2.00A2-487[»]
3AKZX-ray2.90A/B/C/D1-487[»]
3AL0X-ray3.37C1-487[»]
ProteinModelPortaliQ9X2I8.

Miscellaneous databases

EvolutionaryTraceiQ9X2I8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi31 – 4111"HIGH" regionUniRule annotationAdd
BLAST
Motifi254 – 2585"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
KOiK01885.
OMAiEIFDMEY.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X2I8-1 [UniParc]FASTAAdd to Basket

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MFITGAFFDI LEVGPKKIRR CFELVRVRFA PSPTGHLHVG GARTALFNWM    50
FARKEGGKFI LRIEDTDTER SSREYEQQIL ESLRWCGLDW DEGPDIGGDF 100
GPYRQSERLE IYREYAEKLV EDKRAYYVVY DKEDPSKELF TTYEYPHEYK 150
EKGHPVTIKF KVLPGKTSFE DLLKGYMEFD NSTLEDFIIM KSNGFPTYNF 200
AVVVDDHLMR ISHVFRGEDH LSNTPKQLMI YEAFGWEAPV FMHIPLILGS 250
DRTPLSKRHG ATSVEHFRRE GILSRALMNY LALLGWRVEG DEIFTIEEKL 300
QSFDPKDISN KGVIFDYQKL EWVNGKHMRR IDLEDLKREF IEWAKYAGKE 350
IPSVDERYFS ETLRICREKV NTLSQLYDIM YPFMNDDYEY EKDYVEKFLK 400
REEAERVLEE AKKAFKDLNS WNMEEIEKTL RDLSEKGLAS KKVVFQLIRG 450
AVTGKLVTPG LFETIEVLGK ERTLKRLERT LQFLKKT 487
Length:487
Mass (Da):57,382
Last modified:November 1, 1999 - v1
Checksum:i5E15A2E9E1580791
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36937.1.
PIRiF72200.
RefSeqiNP_229671.1. NC_000853.1.
WP_010865423.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD36937; AAD36937; TM_1875.
GeneIDi897796.
KEGGitma:TM1875.
PATRICi23938739. VBITheMar51294_1896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36937.1 .
PIRi F72200.
RefSeqi NP_229671.1. NC_000853.1.
WP_010865423.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AFH X-ray 2.00 A 2-487 [» ]
3AKZ X-ray 2.90 A/B/C/D 1-487 [» ]
3AL0 X-ray 3.37 C 1-487 [» ]
ProteinModelPortali Q9X2I8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59231N.
STRINGi 243274.TM1875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36937 ; AAD36937 ; TM_1875 .
GeneIDi 897796.
KEGGi tma:TM1875.
PATRICi 23938739. VBITheMar51294_1896.

Phylogenomic databases

eggNOGi COG0008.
KOi K01885.
OMAi EIFDMEY.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci TMAR243274:GC6P-1926-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9X2I8.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiSYE2_THEMA
AccessioniPrimary (citable) accession number: Q9X2I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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