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Q9X2E1

- OGG1_THEMA

UniProt

Q9X2E1 - OGG1_THEMA

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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).By similarity

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:TM_1821
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable N-glycosylase/DNA lyasePRO_0000159572Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1821.

Structurei

Secondary structure

207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 3232
Helixi35 – 4713
Turni48 – 503
Helixi53 – 6311
Helixi66 – 694
Helixi72 – 8110
Helixi87 – 9711
Helixi98 – 1003
Turni101 – 1033
Helixi104 – 1096
Helixi112 – 12211
Helixi128 – 1369
Turni137 – 1393
Helixi148 – 1569
Helixi169 – 18618
Helixi190 – 20213

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N0UX-ray1.50A/B/C1-207[»]
ProteinModelPortaliQ9X2E1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2E1.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiCOG1059.
InParanoidiQ9X2E1.
KOiK03653.
OMAiLDLYLWY.
OrthoDBiEOG68SW1J.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X2E1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN
60 70 80 90 100
WSAEGGIRAQ KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL
110 120 130 140 150
LGKLKNLVKG DPFQSREFLV RNAKGIGWKE ASHFLRNTGV EDLAILDKHV
160 170 180 190 200
LRLMKRHGLI QEIPKGWSKK RYLYVEEILR KVAEAFGESP GKFDLYLWYL

VKGKVDK
Length:207
Mass (Da):24,210
Last modified:November 1, 1999 - v1
Checksum:iDB4F7E3EF71C6204
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36884.1.
PIRiH72206.
RefSeqiNP_229618.1. NC_000853.1.
YP_007978180.1. NC_021214.1.
YP_008991080.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36884; AAD36884; TM_1821.
GeneIDi18092868.
897824.
KEGGitma:TM1821.
tmi:THEMA_05090.
tmm:Tmari_1831.
PATRICi23938629. VBITheMar51294_1841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36884.1 .
PIRi H72206.
RefSeqi NP_229618.1. NC_000853.1.
YP_007978180.1. NC_021214.1.
YP_008991080.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3N0U X-ray 1.50 A/B/C 1-207 [» ]
ProteinModelPortali Q9X2E1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1821.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36884 ; AAD36884 ; TM_1821 .
GeneIDi 18092868.
897824.
KEGGi tma:TM1821.
tmi:THEMA_05090.
tmm:Tmari_1831.
PATRICi 23938629. VBITheMar51294_1841.

Phylogenomic databases

eggNOGi COG1059.
InParanoidi Q9X2E1.
KOi K03653.
OMAi LDLYLWY.
OrthoDBi EOG68SW1J.

Miscellaneous databases

EvolutionaryTracei Q9X2E1.

Family and domain databases

HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiOGG1_THEMA
AccessioniPrimary (citable) accession number: Q9X2E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3