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Q9X2E1

- OGG1_THEMA

UniProt

Q9X2E1 - OGG1_THEMA

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.By similarity

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291By similarity

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyase
    Including the following 2 domains:
    8-oxoguanine DNA glycosylase (EC:3.2.2.-)
    DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
    Short name:
    AP lyase
    Gene namesi
    Name:ogg
    Ordered Locus Names:TM_1821
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Probable N-glycosylase/DNA lyasePRO_0000159572Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1821.

    Structurei

    Secondary structure

    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1 – 3232
    Helixi35 – 4713
    Turni48 – 503
    Helixi53 – 6311
    Helixi66 – 694
    Helixi72 – 8110
    Helixi87 – 9711
    Helixi98 – 1003
    Turni101 – 1033
    Helixi104 – 1096
    Helixi112 – 12211
    Helixi128 – 1369
    Turni137 – 1393
    Helixi148 – 1569
    Helixi169 – 18618
    Helixi190 – 20213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3N0UX-ray1.50A/B/C1-207[»]
    ProteinModelPortaliQ9X2E1.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X2E1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.Curated

    Phylogenomic databases

    eggNOGiCOG1059.
    KOiK03653.
    OMAiLDLYLWY.
    OrthoDBiEOG68SW1J.

    Family and domain databases

    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PfamiPF00730. HhH-GPD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X2E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN    50
    WSAEGGIRAQ KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL 100
    LGKLKNLVKG DPFQSREFLV RNAKGIGWKE ASHFLRNTGV EDLAILDKHV 150
    LRLMKRHGLI QEIPKGWSKK RYLYVEEILR KVAEAFGESP GKFDLYLWYL 200
    VKGKVDK 207
    Length:207
    Mass (Da):24,210
    Last modified:November 1, 1999 - v1
    Checksum:iDB4F7E3EF71C6204
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36884.1.
    PIRiH72206.
    RefSeqiNP_229618.1. NC_000853.1.
    YP_007978180.1. NC_021214.1.
    YP_008991080.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36884; AAD36884; TM_1821.
    GeneIDi897824.
    KEGGitma:TM1821.
    tmi:THEMA_05090.
    tmm:Tmari_1831.
    PATRICi23938629. VBITheMar51294_1841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36884.1 .
    PIRi H72206.
    RefSeqi NP_229618.1. NC_000853.1.
    YP_007978180.1. NC_021214.1.
    YP_008991080.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3N0U X-ray 1.50 A/B/C 1-207 [» ]
    ProteinModelPortali Q9X2E1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36884 ; AAD36884 ; TM_1821 .
    GeneIDi 897824.
    KEGGi tma:TM1821.
    tmi:THEMA_05090.
    tmm:Tmari_1831.
    PATRICi 23938629. VBITheMar51294_1841.

    Phylogenomic databases

    eggNOGi COG1059.
    KOi K03653.
    OMAi LDLYLWY.
    OrthoDBi EOG68SW1J.

    Miscellaneous databases

    EvolutionaryTracei Q9X2E1.

    Family and domain databases

    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    Pfami PF00730. HhH-GPD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiOGG1_THEMA
    AccessioniPrimary (citable) accession number: Q9X2E1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3