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Q9X2E1 (OGG1_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:TM_1821
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga ›

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159572

Sites

Active site1291 By similarity

Secondary structure

1 ........................... 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9X2E1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: DB4F7E3EF71C6204

FASTA20724,210
        10         20         30         40         50         60 
MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN WSAEGGIRAQ 

        70         80         90        100        110        120 
KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL LGKLKNLVKG DPFQSREFLV 

       130        140        150        160        170        180 
RNAKGIGWKE ASHFLRNTGV EDLAILDKHV LRLMKRHGLI QEIPKGWSKK RYLYVEEILR 

       190        200 
KVAEAFGESP GKFDLYLWYL VKGKVDK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD36884.1.
PIRH72206.
RefSeqNP_229618.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3N0UX-ray1.50A/B/C1-207[»]
ProteinModelPortalQ9X2E1.
ModBaseSearch...

Protein-protein interaction databases

STRING243274.TM1821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36884; AAD36884; TM_1821.
GeneID897824.
KEGGtma:TM1821.
PATRIC23938629. VBITheMar51294_1841.

Phylogenomic databases

eggNOGCOG1059.
KOK03653.
OMAIIDRHIL.
ProtClustDBPRK01229.

Family and domain databases

HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. DNA_glycsylse. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9X2E1.

Entry information

Entry nameOGG1_THEMA
AccessionPrimary (citable) accession number: Q9X2E1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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