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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).By similarity

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:TM_1821
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable N-glycosylase/DNA lyasePRO_0000159572Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1821.

Structurei

Secondary structure

207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 3232Combined sources
Helixi35 – 4713Combined sources
Turni48 – 503Combined sources
Helixi53 – 6311Combined sources
Helixi66 – 694Combined sources
Helixi72 – 8110Combined sources
Helixi87 – 9711Combined sources
Helixi98 – 1003Combined sources
Turni101 – 1033Combined sources
Helixi104 – 1096Combined sources
Helixi112 – 12211Combined sources
Helixi128 – 1369Combined sources
Turni137 – 1393Combined sources
Helixi148 – 1569Combined sources
Helixi169 – 18618Combined sources
Helixi190 – 20213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N0UX-ray1.50A/B/C1-207[»]
ProteinModelPortaliQ9X2E1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2E1.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiCOG1059.
InParanoidiQ9X2E1.
KOiK03653.
OMAiELCFCIL.
OrthoDBiEOG68SW1J.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X2E1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN
60 70 80 90 100
WSAEGGIRAQ KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL
110 120 130 140 150
LGKLKNLVKG DPFQSREFLV RNAKGIGWKE ASHFLRNTGV EDLAILDKHV
160 170 180 190 200
LRLMKRHGLI QEIPKGWSKK RYLYVEEILR KVAEAFGESP GKFDLYLWYL

VKGKVDK
Length:207
Mass (Da):24,210
Last modified:November 1, 1999 - v1
Checksum:iDB4F7E3EF71C6204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36884.1.
PIRiH72206.
RefSeqiNP_229618.1. NC_000853.1.
YP_007978180.1. NC_021214.1.
YP_008991080.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36884; AAD36884; TM_1821.
GeneIDi18092868.
897824.
KEGGitma:TM1821.
tmi:THEMA_05090.
PATRICi23938629. VBITheMar51294_1841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36884.1.
PIRiH72206.
RefSeqiNP_229618.1. NC_000853.1.
YP_007978180.1. NC_021214.1.
YP_008991080.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N0UX-ray1.50A/B/C1-207[»]
ProteinModelPortaliQ9X2E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36884; AAD36884; TM_1821.
GeneIDi18092868.
897824.
KEGGitma:TM1821.
tmi:THEMA_05090.
PATRICi23938629. VBITheMar51294_1841.

Phylogenomic databases

eggNOGiCOG1059.
InParanoidiQ9X2E1.
KOiK03653.
OMAiELCFCIL.
OrthoDBiEOG68SW1J.

Miscellaneous databases

EvolutionaryTraceiQ9X2E1.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiOGG1_THEMA
AccessioniPrimary (citable) accession number: Q9X2E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.