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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.

Cofactori

pyridoxal 5'-phosphateNote: Binds 1 pyridoxal phosphate per subunit.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ), Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB), Acetylglutamate kinase (Tmari_1793)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126Pyridoxal phosphate; via carbonyl oxygen1
Binding sitei129N2-acetyl-L-ornithineBy similarity1
Binding sitei267N2-acetyl-L-ornithineBy similarity1
Binding sitei268Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferase (EC:2.6.1.11)
Short name:
ACOAT
Gene namesi
Name:argD
Ordered Locus Names:TM_1785
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128051 – 385Acetylornithine aminotransferaseAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240N6-(pyridoxal phosphate)lysine1

Interactioni

Subunit structurei

Homodimer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi243274.TM1785.

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 19Combined sources7
Beta strandi21 – 24Combined sources4
Beta strandi29 – 34Combined sources6
Helixi35 – 38Combined sources4
Helixi47 – 59Combined sources13
Beta strandi67 – 69Combined sources3
Helixi70 – 81Combined sources12
Turni82 – 84Combined sources3
Beta strandi87 – 93Combined sources7
Helixi94 – 112Combined sources19
Beta strandi118 – 123Combined sources6
Helixi131 – 136Combined sources6
Helixi140 – 143Combined sources4
Helixi144 – 146Combined sources3
Beta strandi153 – 156Combined sources4
Helixi161 – 167Combined sources7
Beta strandi172 – 177Combined sources6
Beta strandi179 – 181Combined sources3
Turni183 – 185Combined sources3
Helixi191 – 204Combined sources14
Beta strandi207 – 211Combined sources5
Turni213 – 220Combined sources8
Beta strandi221 – 224Combined sources4
Helixi225 – 229Combined sources5
Beta strandi234 – 238Combined sources5
Helixi240 – 243Combined sources4
Beta strandi249 – 253Combined sources5
Turni255 – 257Combined sources3
Helixi273 – 286Combined sources14
Helixi291 – 312Combined sources22
Beta strandi316 – 322Combined sources7
Beta strandi325 – 330Combined sources6
Helixi336 – 345Combined sources10
Beta strandi351 – 353Combined sources3
Turni354 – 356Combined sources3
Beta strandi357 – 360Combined sources4
Helixi368 – 383Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E54X-ray1.50A1-385[»]
2ORDX-ray1.40A/B1-385[»]
ProteinModelPortaliQ9X2A5.
SMRiQ9X2A5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2A5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 95Pyridoxal phosphate binding2
Regioni211 – 214Pyridoxal phosphate binding4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8Y. Bacteria.
COG4992. LUCA.
InParanoidiQ9X2A5.
KOiK00821.
OMAiDFEPLMP.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3. 1 hit.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00707. argD. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X2A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLMNTYSRF PATFVYGKGS WIYDEKGNAY LDFTSGIAVN VLGHSHPRLV
60 70 80 90 100
EAIKDQAEKL IHCSNLFWNR PQMELAELLS KNTFGGKVFF ANTGTEANEA
110 120 130 140 150
AIKIARKYGK KKSEKKYRIL SAHNSFHGRT LGSLTATGQP KYQKPFEPLV
160 170 180 190 200
PGFEYFEFNN VEDLRRKMSE DVCAVFLEPI QGESGIVPAT KEFLEEARKL
210 220 230 240 250
CDEYDALLVF DEVQCGMGRT GKLFAYQKYG VVPDVLTTAK GLGGGVPIGA
260 270 280 290 300
VIVNERANVL EPGDHGTTFG GNPLACRAGV TVIKELTKEG FLEEVEEKGN
310 320 330 340 350
YLMKKLQEMK EEYDVVADVR GMGLMIGIQF REEVSNREVA TKCFENKLLV
360 370 380
VPAGNNTIRF LPPLTVEYGE IDLAVETLKK VLQGI
Length:385
Mass (Da):42,884
Last modified:November 1, 1999 - v1
Checksum:i4018F87FCBEBFFE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36848.1.
PIRiD72211.
RefSeqiNP_229582.1. NC_000853.1.
WP_004082331.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36848; AAD36848; TM_1785.
GeneIDi897842.
KEGGitma:TM1785.
PATRICi23938555. VBITheMar51294_1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36848.1.
PIRiD72211.
RefSeqiNP_229582.1. NC_000853.1.
WP_004082331.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E54X-ray1.50A1-385[»]
2ORDX-ray1.40A/B1-385[»]
ProteinModelPortaliQ9X2A5.
SMRiQ9X2A5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36848; AAD36848; TM_1785.
GeneIDi897842.
KEGGitma:TM1785.
PATRICi23938555. VBITheMar51294_1805.

Phylogenomic databases

eggNOGiENOG4105C8Y. Bacteria.
COG4992. LUCA.
InParanoidiQ9X2A5.
KOiK00821.
OMAiDFEPLMP.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109.

Miscellaneous databases

EvolutionaryTraceiQ9X2A5.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3. 1 hit.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00707. argD. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGD_THEMA
AccessioniPrimary (citable) accession number: Q9X2A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.