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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ), Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB), Acetylglutamate kinase (Tmari_1793)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase (EC:1.2.1.38)
Short name:
AGPR
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name:
NAGSA dehydrogenase
Gene namesi
Name:argC
Ordered Locus Names:TM_1782
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339N-acetyl-gamma-glutamyl-phosphate reductasePRO_0000112466Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1782.

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Helixi12 – 2312Combined sources
Beta strandi27 – 337Combined sources
Turni36 – 394Combined sources
Helixi42 – 454Combined sources
Helixi47 – 493Combined sources
Helixi60 – 667Combined sources
Beta strandi68 – 725Combined sources
Helixi78 – 836Combined sources
Beta strandi90 – 967Combined sources
Turni97 – 993Combined sources
Helixi103 – 1108Combined sources
Helixi117 – 1193Combined sources
Beta strandi122 – 1243Combined sources
Helixi127 – 1348Combined sources
Beta strandi138 – 1414Combined sources
Helixi145 – 15915Combined sources
Beta strandi166 – 17510Combined sources
Helixi176 – 1794Combined sources
Helixi185 – 1873Combined sources
Helixi189 – 1924Combined sources
Helixi206 – 21813Combined sources
Beta strandi223 – 23513Combined sources
Beta strandi237 – 2448Combined sources
Helixi249 – 26012Combined sources
Beta strandi266 – 2683Combined sources
Helixi277 – 2804Combined sources
Beta strandi286 – 2938Combined sources
Turni294 – 2974Combined sources
Beta strandi298 – 3058Combined sources
Turni307 – 3126Combined sources
Helixi313 – 32311Combined sources
Turni328 – 3314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VKNX-ray1.80A/B/C/D1-339[»]
ProteinModelPortaliQ9X2A2.
SMRiQ9X2A2. Positions 1-339.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2A2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
InParanoidiQ9X2A2.
KOiK00145.
OMAiTFVPHLT.
OrthoDBiEOG6XSZS3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1.
InterProiIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X2A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRAGIIGAT GYTGLELVRL LKNHPEAKIT YLSSRTYAGK KLEEIFPSTL
60 70 80 90 100
ENSILSEFDP EKVSKNCDVL FTALPAGASY DLVRELKGVK IIDLGADFRF
110 120 130 140 150
DDPGVYREWY GKELSGYENI KRVYGLPELH REEIKNAQVV GNPGCYPTSV
160 170 180 190 200
ILALAPALKH NLVDPETILV DAKSGVSGAG RKEKVDYLFS EVNESLRPYN
210 220 230 240 250
VAKHRHVPEM EQELGKISGK KVNVVFTPHL VPMTRGILST IYVKTDKSLE
260 270 280 290 300
EIHEAYLEFY KNEPFVHVLP MGIYPSTKWC YGSNHVFIGM QMEERTNTLI
310 320 330
LMSAIDNLVK GASGQAVQNM NIMFGLDETK GLEFTPIYP
Length:339
Mass (Da):37,936
Last modified:November 1, 1999 - v1
Checksum:iE3152D5D4E4EA116
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36845.1.
PIRiA72211.
RefSeqiNP_229579.1. NC_000853.1.
WP_004082328.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36845; AAD36845; TM_1782.
GeneIDi897760.
KEGGitma:TM1782.
PATRICi23938549. VBITheMar51294_1802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36845.1.
PIRiA72211.
RefSeqiNP_229579.1. NC_000853.1.
WP_004082328.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VKNX-ray1.80A/B/C/D1-339[»]
ProteinModelPortaliQ9X2A2.
SMRiQ9X2A2. Positions 1-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36845; AAD36845; TM_1782.
GeneIDi897760.
KEGGitma:TM1782.
PATRICi23938549. VBITheMar51294_1802.

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
InParanoidiQ9X2A2.
KOiK00145.
OMAiTFVPHLT.
OrthoDBiEOG6XSZS3.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Miscellaneous databases

EvolutionaryTraceiQ9X2A2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1.
InterProiIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiARGC_THEMA
AccessioniPrimary (citable) accession number: Q9X2A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 13, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.