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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ), Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB), Acetylglutamate kinase (Tmari_1793)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase (EC:1.2.1.38)
Short name:
AGPR
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name:
NAGSA dehydrogenase
Gene namesi
Name:argC
Ordered Locus Names:TM_1782
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001124661 – 339N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST339

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1782.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi12 – 23Combined sources12
Beta strandi27 – 33Combined sources7
Turni36 – 39Combined sources4
Helixi42 – 45Combined sources4
Helixi47 – 49Combined sources3
Helixi60 – 66Combined sources7
Beta strandi68 – 72Combined sources5
Helixi78 – 83Combined sources6
Beta strandi90 – 96Combined sources7
Turni97 – 99Combined sources3
Helixi103 – 110Combined sources8
Helixi117 – 119Combined sources3
Beta strandi122 – 124Combined sources3
Helixi127 – 134Combined sources8
Beta strandi138 – 141Combined sources4
Helixi145 – 159Combined sources15
Beta strandi166 – 175Combined sources10
Helixi176 – 179Combined sources4
Helixi185 – 187Combined sources3
Helixi189 – 192Combined sources4
Helixi206 – 218Combined sources13
Beta strandi223 – 235Combined sources13
Beta strandi237 – 244Combined sources8
Helixi249 – 260Combined sources12
Beta strandi266 – 268Combined sources3
Helixi277 – 280Combined sources4
Beta strandi286 – 293Combined sources8
Turni294 – 297Combined sources4
Beta strandi298 – 305Combined sources8
Turni307 – 312Combined sources6
Helixi313 – 323Combined sources11
Turni328 – 331Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VKNX-ray1.80A/B/C/D1-339[»]
ProteinModelPortaliQ9X2A2.
SMRiQ9X2A2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X2A2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
InParanoidiQ9X2A2.
KOiK00145.
OMAiTFVPHLT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X2A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRAGIIGAT GYTGLELVRL LKNHPEAKIT YLSSRTYAGK KLEEIFPSTL
60 70 80 90 100
ENSILSEFDP EKVSKNCDVL FTALPAGASY DLVRELKGVK IIDLGADFRF
110 120 130 140 150
DDPGVYREWY GKELSGYENI KRVYGLPELH REEIKNAQVV GNPGCYPTSV
160 170 180 190 200
ILALAPALKH NLVDPETILV DAKSGVSGAG RKEKVDYLFS EVNESLRPYN
210 220 230 240 250
VAKHRHVPEM EQELGKISGK KVNVVFTPHL VPMTRGILST IYVKTDKSLE
260 270 280 290 300
EIHEAYLEFY KNEPFVHVLP MGIYPSTKWC YGSNHVFIGM QMEERTNTLI
310 320 330
LMSAIDNLVK GASGQAVQNM NIMFGLDETK GLEFTPIYP
Length:339
Mass (Da):37,936
Last modified:November 1, 1999 - v1
Checksum:iE3152D5D4E4EA116
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36845.1.
PIRiA72211.
RefSeqiNP_229579.1. NC_000853.1.
WP_004082328.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36845; AAD36845; TM_1782.
GeneIDi897760.
KEGGitma:TM1782.
PATRICi23938549. VBITheMar51294_1802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36845.1.
PIRiA72211.
RefSeqiNP_229579.1. NC_000853.1.
WP_004082328.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VKNX-ray1.80A/B/C/D1-339[»]
ProteinModelPortaliQ9X2A2.
SMRiQ9X2A2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36845; AAD36845; TM_1782.
GeneIDi897760.
KEGGitma:TM1782.
PATRICi23938549. VBITheMar51294_1802.

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
InParanoidiQ9X2A2.
KOiK00145.
OMAiTFVPHLT.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Miscellaneous databases

EvolutionaryTraceiQ9X2A2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGC_THEMA
AccessioniPrimary (citable) accession number: Q9X2A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.