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Q9X2A1

- ASSY_THEMA

UniProt

Q9X2A1 - ASSY_THEMA

Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei85 – 851CitrullineUniRule annotation
    Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171AspartateUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei121 – 1211CitrullineUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei178 – 1781CitrullineUniRule annotation
    Binding sitei187 – 1871CitrullineUniRule annotation
    Binding sitei268 – 2681CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:TM_1780
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Argininosuccinate synthasePRO_0000148656Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.1 PublicationUniRule annotation

    Protein-protein interaction databases

    STRINGi243274.TM1780.

    Structurei

    Secondary structure

    1
    409
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 85
    Helixi13 – 2412
    Beta strandi28 – 3710
    Helixi42 – 5211
    Beta strandi55 – 617
    Helixi63 – 697
    Helixi71 – 755
    Turni76 – 783
    Turni82 – 843
    Helixi88 – 10720
    Beta strandi110 – 1134
    Helixi122 – 13312
    Beta strandi137 – 1404
    Helixi142 – 1443
    Helixi146 – 1516
    Helixi157 – 1659
    Beta strandi176 – 1816
    Beta strandi186 – 1905
    Helixi191 – 1944
    Helixi202 – 2043
    Turni211 – 2133
    Beta strandi219 – 2268
    Beta strandi229 – 2357
    Turni236 – 2383
    Helixi245 – 25814
    Beta strandi263 – 2697
    Beta strandi271 – 28111
    Helixi283 – 29917
    Helixi302 – 32120
    Helixi327 – 34014
    Beta strandi345 – 3528
    Beta strandi355 – 3628
    Beta strandi364 – 3663
    Helixi383 – 40422

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VL2X-ray1.65A/B/C/D1-409[»]
    ProteinModelPortaliQ9X2A1.
    SMRiQ9X2A1. Positions 2-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X2A1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X2A1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEKVVLAYS GGLDTSVILK WLCEKGFDVI AYVANVGQKD DFVAIKEKAL    50
    KTGASKVYVE DLRREFVTDY IFTALLGNAM YEGRYLLGTA IARPLIAKRQ 100
    VEIAEKEGAQ YVAHGATGKG NDQVRFELTY AALNPNLKVI SPWKDPEFLA 150
    KFKGRTDLIN YAMEKGIPIK VSKKRPYSED ENLMHISHEA GKLEDPAHIP 200
    DEDVFTWTVS PKDAPDEETL LEIHFENGIP VKVVNLKDGT EKTDPLELFE 250
    YLNEVGAKNG VGRLDMVENR FIGIKSRGVY ETPGATILWI AHRDLEGITM 300
    DKEVMHLRDM LAPKFAELIY NGFWFSPEME FLLAAFRKAQ ENVTGKVTVS 350
    IYKGNVMPVA RYSPYSLYNP ELSSMDVEGG FDATDSKGFI NIHALRLKVH 400
    QLVKKGYQR 409
    Length:409
    Mass (Da):46,054
    Last modified:November 1, 1999 - v1
    Checksum:iECCDC8575E962482
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36844.1.
    PIRiH72210.
    RefSeqiNP_229577.1. NC_000853.1.
    YP_007978138.1. NC_021214.1.
    YP_008991121.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36844; AAD36844; TM_1780.
    GeneIDi897844.
    KEGGitma:TM1780.
    tmi:THEMA_05300.
    tmm:Tmari_1789.
    PATRICi23938542. VBITheMar51294_1799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36844.1 .
    PIRi H72210.
    RefSeqi NP_229577.1. NC_000853.1.
    YP_007978138.1. NC_021214.1.
    YP_008991121.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VL2 X-ray 1.65 A/B/C/D 1-409 [» ]
    ProteinModelPortali Q9X2A1.
    SMRi Q9X2A1. Positions 2-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1780.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36844 ; AAD36844 ; TM_1780 .
    GeneIDi 897844.
    KEGGi tma:TM1780.
    tmi:THEMA_05300.
    tmm:Tmari_1789.
    PATRICi 23938542. VBITheMar51294_1799.

    Phylogenomic databases

    eggNOGi COG0137.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .

    Miscellaneous databases

    EvolutionaryTracei Q9X2A1.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    2. "Crystal structure of argininosuccinate synthase (TM1780) from Thermotoga maritima at 1.65 A resolution."
      Joint center for structural genomics (JCSG)
      Submitted (MAR-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiASSY_THEMA
    AccessioniPrimary (citable) accession number: Q9X2A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3