Reviewed, UniProtKB/Swiss-Prot Q9X295 (APGM_THEMA)

Names and origin

Protein names

Recommended name:
    Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
      Short name=Phosphoglyceromutase
      Short name=BPG-independent PGAM
      Short name=aPGAM
    EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	TM_1774

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402		PRO_0000138155

Sequences

	Sequence		Length	Mass (Da)
	Q9X295-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9B2FB45F1C154411	FASTA	401	44,275
	10 20 30 40 50 60 MFDKQEFVSK LVTEEKAKIV LLVMDGLGDI PVNGKTPLQA ANTPNLDNLA KESDLGQTIP 70 80 90 100 110 120 VLPGITPGSG PGHLSLFGYD PIKYQIGRGI LEALGIGVEV GEKDVVARAN FATWDGKVVL 130 140 150 160 170 180 DRRAGRPATE ESAKVVQLLS EKIKKIEDVE ITFYPGKEHR FVVKFTGEGL GDKVTDADPQ 190 200 210 220 230 240 KEGHPMVWAE GLDEPSKKTA RIVNELIKKI AEVLKDNPKI NFALIRGFSK YPDLPKFPQV 250 260 270 280 290 300 YKMKAGAIAT YPMYRGLAKL VGMEIIETGQ TVADEIKTLK EKWNDYDFFY VHVKKTDSYG 310 320 330 340 350 360 EDGKFEEKVK VIEEVDAIIP EIVSLNPDVL VITGDHSTPV PLKAHSWHPV PLLIWSKYTR 370 380 390 400 RGLSQAFNEF ECARGTLGTI HASDVMTLAL AYAGKLEKFG A

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000512 Genomic DNA. Translation: AAD36837.1.
PIR	E72213.
RefSeq	NP_229571.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	897849.
GenomeReviews	Gene locus TM_1774 in contig AE000512_GR.
KEGG	tma:TM1774.
NMPDR	fig|243274.1.peg.1755.
TIGR	TM_1774.
Phylogenomic databases
HOGENOM	Q9X295.
OMA	ITGDHST.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_1774-MON.
BRENDA	5.4.2.1. 16699.
Family and domain databases
HAMAP	MF_01402. [Tree]
InterPro	IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
ProDom	PD004704. APGAM_DeoB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00306. apgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_THEMA

Accession

Primary (citable) accession number: Q9X295

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)