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Q9X287

- FTHS_THEMA

UniProt

Q9X287 - FTHS_THEMA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi53 – 608ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTMAR243274:GC6P-1815-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:TM_1766
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Formate--tetrahydrofolate ligasePRO_0000199403Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1766.

    Structurei

    Secondary structure

    1
    542
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 107
    Helixi15 – 173
    Beta strandi18 – 214
    Turni22 – 243
    Beta strandi25 – 284
    Helixi32 – 354
    Turni36 – 383
    Beta strandi43 – 519
    Helixi59 – 7214
    Beta strandi77 – 815
    Helixi86 – 916
    Beta strandi102 – 1065
    Helixi107 – 1115
    Turni112 – 1154
    Helixi117 – 13721
    Beta strandi144 – 1496
    Beta strandi153 – 1575
    Helixi160 – 1623
    Beta strandi163 – 1686
    Helixi172 – 1743
    Beta strandi178 – 1803
    Beta strandi182 – 1843
    Helixi185 – 1873
    Helixi189 – 1968
    Helixi200 – 2089
    Beta strandi211 – 2155
    Beta strandi220 – 2223
    Helixi223 – 2264
    Helixi229 – 2357
    Turni236 – 2405
    Beta strandi243 – 2475
    Beta strandi252 – 2554
    Beta strandi261 – 2644
    Helixi270 – 27910
    Beta strandi281 – 29010
    Turni291 – 2933
    Helixi294 – 3007
    Helixi302 – 3065
    Beta strandi311 – 3177
    Helixi319 – 3257
    Helixi330 – 3323
    Helixi338 – 35720
    Beta strandi362 – 3676
    Helixi374 – 38512
    Turni386 – 3883
    Beta strandi390 – 3945
    Helixi396 – 3994
    Helixi400 – 4034
    Helixi405 – 41410
    Helixi430 – 44011
    Beta strandi445 – 4495
    Helixi451 – 46212
    Beta strandi470 – 4734
    Beta strandi476 – 4816
    Beta strandi493 – 4964
    Beta strandi498 – 5025
    Turni503 – 5064
    Beta strandi507 – 5115
    Helixi526 – 5294
    Beta strandi538 – 5403

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DO6X-ray1.85A/B1-542[»]
    ProteinModelPortaliQ9X287.
    SMRiQ9X287. Positions 1-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X287.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X287-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPIKEIADQ LELKDDILYP YGHYIAKIDH RFLKSLENHE DGKLILVTAV    50
    TPTPAGEGKT TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG 100
    RSRVLPSDEI NLHFTGDMHA VASAHNLLAA VLDSHIKHGN ELKIDITRVF 150
    WKRTMDMNDR ALRSIVIGLG GSANGFPRED SFIITAASEV MAILALSENM 200
    KDLKERLGKI IVALDADRKI VRISDLGIQG AMAVLLKDAI NPNLVQTTEG 250
    TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID 300
    FVSRVGGFYP NAAVLVATVR ALKYHGGANL KNIHEENLEA LKEGFKNLRV 350
    HVENLRKFNL PVVVALNRFS TDTEKEIAYV VKECEKLGVR VAVSEVFKKG 400
    SEGGVELAKA VAEAAKDVEP AYLYEMNDPV EKKIEILAKE IYRAGRVEFS 450
    DTAKNALKFI KKHGFDELPV IVAKTPKSIS HDPSLRGAPE GYTFVVSDLF 500
    VSAGAGFVVA LSGDINLMPG LPKKPNALNM DVDDSGNIVG VS 542
    Length:542
    Mass (Da):58,538
    Last modified:November 1, 1999 - v1
    Checksum:iBC3AE16461AF326E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36830.1.
    PIRiE72212.
    RefSeqiNP_229563.1. NC_000853.1.
    YP_007978124.1. NC_021214.1.
    YP_008991139.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36830; AAD36830; TM_1766.
    GeneIDi897854.
    KEGGitma:TM1766.
    tmi:THEMA_05395.
    tmm:Tmari_1775.
    PATRICi23938512. VBITheMar51294_1785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36830.1 .
    PIRi E72212.
    RefSeqi NP_229563.1. NC_000853.1.
    YP_007978124.1. NC_021214.1.
    YP_008991139.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DO6 X-ray 1.85 A/B 1-542 [» ]
    ProteinModelPortali Q9X287.
    SMRi Q9X287. Positions 1-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36830 ; AAD36830 ; TM_1766 .
    GeneIDi 897854.
    KEGGi tma:TM1766.
    tmi:THEMA_05395.
    tmm:Tmari_1775.
    PATRICi 23938512. VBITheMar51294_1785.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TMAR243274:GC6P-1815-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9X287.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiFTHS_THEMA
    AccessioniPrimary (citable) accession number: Q9X287
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3