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Q9X287

- FTHS_THEMA

UniProt

Q9X287 - FTHS_THEMA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1815-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TM_1766
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Formate--tetrahydrofolate ligasePRO_0000199403Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1766.

Structurei

Secondary structure

1
542
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 107
Helixi15 – 173
Beta strandi18 – 214
Turni22 – 243
Beta strandi25 – 284
Helixi32 – 354
Turni36 – 383
Beta strandi43 – 519
Helixi59 – 7214
Beta strandi77 – 815
Helixi86 – 916
Beta strandi102 – 1065
Helixi107 – 1115
Turni112 – 1154
Helixi117 – 13721
Beta strandi144 – 1496
Beta strandi153 – 1575
Helixi160 – 1623
Beta strandi163 – 1686
Helixi172 – 1743
Beta strandi178 – 1803
Beta strandi182 – 1843
Helixi185 – 1873
Helixi189 – 1968
Helixi200 – 2089
Beta strandi211 – 2155
Beta strandi220 – 2223
Helixi223 – 2264
Helixi229 – 2357
Turni236 – 2405
Beta strandi243 – 2475
Beta strandi252 – 2554
Beta strandi261 – 2644
Helixi270 – 27910
Beta strandi281 – 29010
Turni291 – 2933
Helixi294 – 3007
Helixi302 – 3065
Beta strandi311 – 3177
Helixi319 – 3257
Helixi330 – 3323
Helixi338 – 35720
Beta strandi362 – 3676
Helixi374 – 38512
Turni386 – 3883
Beta strandi390 – 3945
Helixi396 – 3994
Helixi400 – 4034
Helixi405 – 41410
Helixi430 – 44011
Beta strandi445 – 4495
Helixi451 – 46212
Beta strandi470 – 4734
Beta strandi476 – 4816
Beta strandi493 – 4964
Beta strandi498 – 5025
Turni503 – 5064
Beta strandi507 – 5115
Helixi526 – 5294
Beta strandi538 – 5403

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DO6X-ray1.85A/B1-542[»]
ProteinModelPortaliQ9X287.
SMRiQ9X287. Positions 1-540.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X287.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
InParanoidiQ9X287.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X287 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPIKEIADQ LELKDDILYP YGHYIAKIDH RFLKSLENHE DGKLILVTAV
60 70 80 90 100
TPTPAGEGKT TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG
110 120 130 140 150
RSRVLPSDEI NLHFTGDMHA VASAHNLLAA VLDSHIKHGN ELKIDITRVF
160 170 180 190 200
WKRTMDMNDR ALRSIVIGLG GSANGFPRED SFIITAASEV MAILALSENM
210 220 230 240 250
KDLKERLGKI IVALDADRKI VRISDLGIQG AMAVLLKDAI NPNLVQTTEG
260 270 280 290 300
TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID
310 320 330 340 350
FVSRVGGFYP NAAVLVATVR ALKYHGGANL KNIHEENLEA LKEGFKNLRV
360 370 380 390 400
HVENLRKFNL PVVVALNRFS TDTEKEIAYV VKECEKLGVR VAVSEVFKKG
410 420 430 440 450
SEGGVELAKA VAEAAKDVEP AYLYEMNDPV EKKIEILAKE IYRAGRVEFS
460 470 480 490 500
DTAKNALKFI KKHGFDELPV IVAKTPKSIS HDPSLRGAPE GYTFVVSDLF
510 520 530 540
VSAGAGFVVA LSGDINLMPG LPKKPNALNM DVDDSGNIVG VS
Length:542
Mass (Da):58,538
Last modified:November 1, 1999 - v1
Checksum:iBC3AE16461AF326E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36830.1.
PIRiE72212.
RefSeqiNP_229563.1. NC_000853.1.
WP_010865397.1. NC_023151.1.
YP_007978124.1. NC_021214.1.
YP_008991139.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36830; AAD36830; TM_1766.
GeneIDi18092929.
897854.
KEGGitma:TM1766.
tmi:THEMA_05395.
tmm:Tmari_1775.
PATRICi23938512. VBITheMar51294_1785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36830.1 .
PIRi E72212.
RefSeqi NP_229563.1. NC_000853.1.
WP_010865397.1. NC_023151.1.
YP_007978124.1. NC_021214.1.
YP_008991139.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DO6 X-ray 1.85 A/B 1-542 [» ]
ProteinModelPortali Q9X287.
SMRi Q9X287. Positions 1-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36830 ; AAD36830 ; TM_1766 .
GeneIDi 18092929.
897854.
KEGGi tma:TM1766.
tmi:THEMA_05395.
tmm:Tmari_1775.
PATRICi 23938512. VBITheMar51294_1785.

Phylogenomic databases

eggNOGi COG2759.
InParanoidi Q9X287.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TMAR243274:GC6P-1815-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9X287.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiFTHS_THEMA
AccessioniPrimary (citable) accession number: Q9X287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3