Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9X287 (FTHS_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:TM_1766
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199403

Regions

Nucleotide binding53 – 608ATP By similarity

Secondary structure

......................................................................................................... 542
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9X287 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: BC3AE16461AF326E

FASTA54258,538
        10         20         30         40         50         60 
MKPIKEIADQ LELKDDILYP YGHYIAKIDH RFLKSLENHE DGKLILVTAV TPTPAGEGKT 

        70         80         90        100        110        120 
TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG RSRVLPSDEI NLHFTGDMHA 

       130        140        150        160        170        180 
VASAHNLLAA VLDSHIKHGN ELKIDITRVF WKRTMDMNDR ALRSIVIGLG GSANGFPRED 

       190        200        210        220        230        240 
SFIITAASEV MAILALSENM KDLKERLGKI IVALDADRKI VRISDLGIQG AMAVLLKDAI 

       250        260        270        280        290        300 
NPNLVQTTEG TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID 

       310        320        330        340        350        360 
FVSRVGGFYP NAAVLVATVR ALKYHGGANL KNIHEENLEA LKEGFKNLRV HVENLRKFNL 

       370        380        390        400        410        420 
PVVVALNRFS TDTEKEIAYV VKECEKLGVR VAVSEVFKKG SEGGVELAKA VAEAAKDVEP 

       430        440        450        460        470        480 
AYLYEMNDPV EKKIEILAKE IYRAGRVEFS DTAKNALKFI KKHGFDELPV IVAKTPKSIS 

       490        500        510        520        530        540 
HDPSLRGAPE GYTFVVSDLF VSAGAGFVVA LSGDINLMPG LPKKPNALNM DVDDSGNIVG 


VS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD36830.1.
PIRE72212.
RefSeqNP_229563.1. NC_000853.1.
YP_007978124.1. NC_021214.1.
YP_008991139.1. NC_023151.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DO6X-ray1.85A/B1-542[»]
ProteinModelPortalQ9X287.
SMRQ9X287. Positions 1-540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM1766.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36830; AAD36830; TM_1766.
GeneID15495377.
18092929.
897854.
KEGGtma:TM1766.
tmm:Tmari_1775.
PATRIC23938512. VBITheMar51294_1785.

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycTMAR243274:GC6P-1815-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9X287.

Entry information

Entry nameFTHS_THEMA
AccessionPrimary (citable) accession number: Q9X287
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways