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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 60ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TM_1766
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994031 – 542Formate--tetrahydrofolate ligaseAdd BLAST542

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1766.

Structurei

Secondary structure

1542
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 10Combined sources7
Helixi15 – 17Combined sources3
Beta strandi18 – 21Combined sources4
Turni22 – 24Combined sources3
Beta strandi25 – 28Combined sources4
Helixi32 – 35Combined sources4
Turni36 – 38Combined sources3
Beta strandi43 – 51Combined sources9
Helixi59 – 72Combined sources14
Beta strandi77 – 81Combined sources5
Helixi86 – 91Combined sources6
Beta strandi102 – 106Combined sources5
Helixi107 – 111Combined sources5
Turni112 – 115Combined sources4
Helixi117 – 137Combined sources21
Beta strandi144 – 149Combined sources6
Beta strandi153 – 157Combined sources5
Helixi160 – 162Combined sources3
Beta strandi163 – 168Combined sources6
Helixi172 – 174Combined sources3
Beta strandi178 – 180Combined sources3
Beta strandi182 – 184Combined sources3
Helixi185 – 187Combined sources3
Helixi189 – 196Combined sources8
Helixi200 – 208Combined sources9
Beta strandi211 – 215Combined sources5
Beta strandi220 – 222Combined sources3
Helixi223 – 226Combined sources4
Helixi229 – 235Combined sources7
Turni236 – 240Combined sources5
Beta strandi243 – 247Combined sources5
Beta strandi252 – 255Combined sources4
Beta strandi261 – 264Combined sources4
Helixi270 – 279Combined sources10
Beta strandi281 – 290Combined sources10
Turni291 – 293Combined sources3
Helixi294 – 300Combined sources7
Helixi302 – 306Combined sources5
Beta strandi311 – 317Combined sources7
Helixi319 – 325Combined sources7
Helixi330 – 332Combined sources3
Helixi338 – 357Combined sources20
Beta strandi362 – 367Combined sources6
Helixi374 – 385Combined sources12
Turni386 – 388Combined sources3
Beta strandi390 – 394Combined sources5
Helixi396 – 399Combined sources4
Helixi400 – 403Combined sources4
Helixi405 – 414Combined sources10
Helixi430 – 440Combined sources11
Beta strandi445 – 449Combined sources5
Helixi451 – 462Combined sources12
Beta strandi470 – 473Combined sources4
Beta strandi476 – 481Combined sources6
Beta strandi493 – 496Combined sources4
Beta strandi498 – 502Combined sources5
Turni503 – 506Combined sources4
Beta strandi507 – 511Combined sources5
Helixi526 – 529Combined sources4
Beta strandi538 – 540Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DO6X-ray1.85A/B1-542[»]
ProteinModelPortaliQ9X287.
SMRiQ9X287.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X287.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
InParanoidiQ9X287.
KOiK01938.
OMAiCGEIMTM.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPIKEIADQ LELKDDILYP YGHYIAKIDH RFLKSLENHE DGKLILVTAV
60 70 80 90 100
TPTPAGEGKT TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG
110 120 130 140 150
RSRVLPSDEI NLHFTGDMHA VASAHNLLAA VLDSHIKHGN ELKIDITRVF
160 170 180 190 200
WKRTMDMNDR ALRSIVIGLG GSANGFPRED SFIITAASEV MAILALSENM
210 220 230 240 250
KDLKERLGKI IVALDADRKI VRISDLGIQG AMAVLLKDAI NPNLVQTTEG
260 270 280 290 300
TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID
310 320 330 340 350
FVSRVGGFYP NAAVLVATVR ALKYHGGANL KNIHEENLEA LKEGFKNLRV
360 370 380 390 400
HVENLRKFNL PVVVALNRFS TDTEKEIAYV VKECEKLGVR VAVSEVFKKG
410 420 430 440 450
SEGGVELAKA VAEAAKDVEP AYLYEMNDPV EKKIEILAKE IYRAGRVEFS
460 470 480 490 500
DTAKNALKFI KKHGFDELPV IVAKTPKSIS HDPSLRGAPE GYTFVVSDLF
510 520 530 540
VSAGAGFVVA LSGDINLMPG LPKKPNALNM DVDDSGNIVG VS
Length:542
Mass (Da):58,538
Last modified:November 1, 1999 - v1
Checksum:iBC3AE16461AF326E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36830.1.
PIRiE72212.
RefSeqiNP_229563.1. NC_000853.1.
WP_010865397.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36830; AAD36830; TM_1766.
GeneIDi897854.
KEGGitma:TM1766.
PATRICi23938512. VBITheMar51294_1785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36830.1.
PIRiE72212.
RefSeqiNP_229563.1. NC_000853.1.
WP_010865397.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DO6X-ray1.85A/B1-542[»]
ProteinModelPortaliQ9X287.
SMRiQ9X287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36830; AAD36830; TM_1766.
GeneIDi897854.
KEGGitma:TM1766.
PATRICi23938512. VBITheMar51294_1785.

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
InParanoidiQ9X287.
KOiK01938.
OMAiCGEIMTM.

Enzyme and pathway databases

UniPathwayiUPA00193.

Miscellaneous databases

EvolutionaryTraceiQ9X287.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTHS_THEMA
AccessioniPrimary (citable) accession number: Q9X287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.