Q9X278 (BUK2_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable butyrate kinase 2
Short name=BK 2
EC=2.7.2.7

Alternative name(s):
Branched-chain carboxylic acid kinase 2

Gene names

Name:	buk2
Ordered Locus Names:	TM_1756

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + butanoate = ADP + butanoyl phosphate. HAMAP MF_00542
Subcellular location	Cytoplasm By similarity HAMAP MF_00542.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW butyrate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 375

375

Probable butyrate kinase 2 HAMAP MF_00542

PRO_0000107675

Secondary structure

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375

Helix Strand Turn

Details...

Beta strand

3 – 9

7

Beta strand

11 – 20

10

Beta strand

23 – 31

9

Helix

34 – 38

5

Helix

43 – 46

4

Helix

47 – 59

13

Turn

60 – 62

3

Helix

65 – 67

3

Beta strand

69 – 74

6

Beta strand

83 – 87

5

Helix

90 – 98

9

Turn

99 – 101

3

Helix

107 – 120

14

Beta strand

124 – 128

5

Helix

137 – 139

3

Helix

155 – 168

14

Helix

173 – 175

3

Beta strand

177 – 193

17

Beta strand

196 – 200

5

Helix

203 – 205

3

Helix

220 – 227

8

Helix

236 – 238

3

Turn

240 – 243

4

Helix

247 – 251

5

Helix

256 – 264

9

Helix

268 – 291

24

Turn

292 – 294

3

Beta strand

297 – 303

7

Helix

304 – 307

4

Turn

309 – 311

3

Helix

312 – 320

9

Turn

321 – 323

3

Beta strand

326 – 331

6

Helix

334 – 346

13

Helix

355 – 369

15

Helix

371 – 373

3

Sequences

	Sequence		Length	Mass (Da)
	Q9X278 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: E42C4887071D008D	FASTA	375	42,022
	10 20 30 40 50 60 MFRILTINPG STSTKLSIFE DERMVKMQNF SHSPDELGRF QKILDQLEFR EKIARQFVEE 70 80 90 100 110 120 TGYSLSSFSA FVSRGGLLDP IPGGVYLVDG LMIKTLKSGK NGEHASNLGA IIAHRFSSET 130 140 150 160 170 180 GVPAYVVDPV VVDEMEDVAR VSGHPNYQRK SIFHALNQKT VAKEVARMMN KRYEEMNLVV 190 200 210 220 230 240 AHMGGGISIA AHRKGRVIDV NNALDGDGPF TPERSGTLPL TQLVDLCFSG KFTYEEMKKR 250 260 270 280 290 300 IVGNGGLVAY LGTSDAREVV RRIKQGDEWA KRVYRAMAYQ IAKWIGKMAA VLKGEVDFIV 310 320 330 340 350 360 LTGGLAHEKE FLVPWITKRV SFIAPVLVFP GSNEEKALAL SALRVLRGEE KPKNYSEESR 370 RWRERYDSYL DGILR

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

+

Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD36821.1.

PIR

E72214.

RefSeq

NP_229554.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1SAZ	X-ray	2.50	A	1-375	[»]
1X9J	X-ray	3.00	A/B/C/D/E/F/G/H	1-375	[»]

ProteinModelPortal

Q9X278.

SMR

Q9X278. Positions 1-375.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

897722.

GenomeReviews

Gene locus TM_1756 in contig AE000512_GR.

KEGG

tma:TM1756.

NMPDR

fig|243274.1.peg.1738.

PATRIC

23938488. VBITheMar51294_1774.

TIGR

TM_1756.

Phylogenomic databases

HOGENOM

HBG449785.

OMA

RSIFHAL.

PhylomeDB

Q9X278.

ProtClustDB

PRK03011.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_1756-MONOMER.

Family and domain databases

HAMAP

MF_00542. Butyrate_kinase.
[Tree]

InterPro

IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR011245. Butyrate_kin.
[Graphical view]

KO

K00929.

PANTHER

PTHR21060. Acetate_kin. 1 hit.
PTHR21060:SF3. Butyrate_kin. 1 hit.

Pfam

PF00871. Acetate_kinase. 1 hit.
[Graphical view]

PIRSF

PIRSF036458. Butyrate_kin. 1 hit.

PRINTS

PR00471. ACETATEKNASE.

TIGRFAMs

TIGR02707. Butyr_kinase. 1 hit.

PROSITE

PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

BUK2_THEMA

Accession

Primary (citable) accession number: Q9X278

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program