Q9X266 (Q9X266_THEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
L-allo-threonine aldolase EMBL AAD36809.1

Gene names

Ordered Locus Names:

TM_1744

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Calcium PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 2FM1 PDB 1M6S Metal-binding PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 2FM1 PDB 1M6S Pyridoxal phosphate PDB 1LW4 PDB 1LW5
Technical term	3D-structure PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 2FM1 PDB 1M6S Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	lyase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	8	1	Calcium 1; via carbonyl oxygen PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 1M6S
	Metal binding	10	1	Calcium 1 PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 1M6S
	Metal binding	198	1	Calcium 1; via carbonyl oxygen PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 1M6S
	Metal binding	203	1	Calcium 1; via carbonyl oxygen PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 1M6S
	Metal binding	232	1	Calcium 1 PDB 1JG8 PDB 1LW4 PDB 1LW5 PDB 1M6S
	Metal binding	326	1	Calcium 2 PDB 1JG8
	Metal binding	329	1	Calcium 2 PDB 1JG8
Amino acid modifications
	Modified residue	199	1	Pyridoxal phosphate PDB 1LW4 PDB 1LW5

Sequences

	Sequence		Length	Mass (Da)
	Q9X266 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: E72FB364989F0554	FASTA	343	37,574
	10 20 30 40 50 60 MIDLRSDTVT KPTEEMRKAM AQAEVGDDVY GEDPTINELE RLAAETFGKE AALFVPSGTM 70 80 90 100 110 120 GNQVSIMAHT QRGDEVILEA DSHIFWYEVG AMAVLSGVMP HPVPGKNGAM DPDDVRKAIR 130 140 150 160 170 180 PRNIHFPRTS LIAIENTHNR SGGRVVPLEN IKEICTIAKE HGINVHIDGA RIFNASIASG 190 200 210 220 230 240 VPVKEYAGYA DSVMFCLSKG LCAPVGSVVV GDRDFIERAR KARKMLGGGM RQAGVLAAAG 250 260 270 280 290 300 IIALTKMVDR LKEDHENARF LALKLKEIGY SVNPEDVKTN MVILRTDNLK VNAHGFIEAL 310 320 330 340 RNSGVLANAV SDTEIRLVTH KDVSRNDIEE ALNIFEKLFR KFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"X-ray structures of threonine aldolase complexes: structural basis of substrate recognition." Kielkopf C.L., Burley S.K. Biochemistry 41:11711-11720(2002) [PubMed: 12269813] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH CALCIUM, PYRIDOXAL PHOSPHATE AT LYS-199.
[3]	"Crystal Structure of Low-specificity Threonine Aldolase, a Key Enzyme in Glycine Biosynthesis." Kielkopf C.L., Bonanno J., Ray S., Burley S.K. Submitted (JUN-2001) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH CALCIUM.
[4]	"Crystal structure of L-ALLO-threonine aldolase (tm1744) from Thermotoga maritima at 2.25 A resolution." Joint Center for Structural Genomics (JCSG) Submitted (JAN-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD36809.1.

PIR

C72215.

RefSeq

NP_229542.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JG8	X-ray	1.80	A/B/C/D	1-343	[»]
1LW4	X-ray	1.90	A/B/C/D	1-343	[»]
1LW5	X-ray	2.05	A/B/C/D	1-343	[»]
1M6S	X-ray	1.80	A/B/C/D	1-343	[»]
2FM1	X-ray	2.25	A/B/C/D	1-343	[»]

ProteinModelPortal

Q9X266.

SMR

Q9X266. Positions 1-343.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

897167.

GenomeReviews

Gene locus TM_1744 in contig AE000512_GR.

KEGG

tma:TM1744.

NMPDR

fig|243274.1.peg.1726.

PATRIC

23938464. VBITheMar51294_1762.

TIGR

TM_1744.

Phylogenomic databases

HOGENOM

HBG293912.

OMA

QDMAAEM.

PhylomeDB

Q9X266.

ProtClustDB

CLSK875950.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_1744-MONOMER.

Family and domain databases

InterPro

IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR023603. Threonine_aldolase.
[Graphical view]

Gene3D

G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.

KO

K01620.

Pfam

PF01212. Beta_elim_lyase. 1 hit.
[Graphical view]

PIRSF

PIRSF017617. Thr_aldolase. 1 hit.

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9X266_THEMA

Accession

Primary (citable) accession number: Q9X266

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)