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Q9X255

- NADK_THEMA

UniProt

Q9X255 - NADK_THEMA

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Protein

NAD kinase

Gene

NADK

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.By similarity

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptorUniRule annotation
Binding sitei130 – 1301NADUniRule annotation
Binding sitei149 – 1491NADUniRule annotation
Binding sitei184 – 1841NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 522NADUniRule annotation
Nucleotide bindingi119 – 1202NADUniRule annotation
Nucleotide bindingi160 – 1656NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.23. 6331.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:NADK
Ordered Locus Names:TM_1733
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258NAD kinasePRO_0000120680Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243274.TM1733.

Structurei

Secondary structure

1
258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76
Helixi9 – 113
Helixi12 – 2211
Turni23 – 253
Beta strandi26 – 3611
Beta strandi43 – 497
Helixi51 – 588
Beta strandi66 – 749
Helixi83 – 853
Helixi86 – 949
Beta strandi99 – 11012
Beta strandi113 – 12412
Beta strandi132 – 1387
Beta strandi144 – 15411
Helixi157 – 1604
Turni161 – 1677
Beta strandi177 – 1848
Beta strandi193 – 1964
Beta strandi201 – 21313
Beta strandi216 – 23722
Helixi243 – 2519

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YT5X-ray2.30A/B/C/D1-258[»]
ProteinModelPortaliQ9X255.
SMRiQ9X255. Positions 1-256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X255.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
InParanoidiQ9X255.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIAILYREE REKEGEFLKE KISKEHEVIE FGEANAPGRV TADLIVVVGG
60 70 80 90 100
DGTVLKAAKK AADGTPMVGF KAGRLGFLTS YTLDEIDRFL EDLRNWNFRE
110 120 130 140 150
ETRWFIQIES ELGNHLALND VTLERDLSGK MVEIEVEVEH HSSMWFFADG
160 170 180 190 200
VVISTPTGST AYSLSIGGPI IFPECEVLEI SPIAPQFFLT RSVVIPSNFK
210 220 230 240 250
VVVESQRDIN MLVDGVLTGK TKRIEVKKSR RYVRILRPPE YDYVTVIRDK

LGYGRRIE
Length:258
Mass (Da):29,242
Last modified:November 1, 1999 - v1
Checksum:i45EBBCA0B6FD3EAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36798.1.
PIRiD72217.
RefSeqiNP_229531.1. NC_000853.1.
WP_004082250.1. NC_023151.1.
YP_007978090.1. NC_021214.1.
YP_008991173.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36798; AAD36798; TM_1733.
GeneIDi18092964.
897872.
KEGGitma:TM1733.
tmi:THEMA_05570.
tmm:Tmari_1741.
PATRICi23938442. VBITheMar51294_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36798.1 .
PIRi D72217.
RefSeqi NP_229531.1. NC_000853.1.
WP_004082250.1. NC_023151.1.
YP_007978090.1. NC_021214.1.
YP_008991173.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YT5 X-ray 2.30 A/B/C/D 1-258 [» ]
ProteinModelPortali Q9X255.
SMRi Q9X255. Positions 1-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1733.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36798 ; AAD36798 ; TM_1733 .
GeneIDi 18092964.
897872.
KEGGi tma:TM1733.
tmi:THEMA_05570.
tmm:Tmari_1741.
PATRICi 23938442. VBITheMar51294_1751.

Phylogenomic databases

eggNOGi COG0061.
InParanoidi Q9X255.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BRENDAi 2.7.1.23. 6331.

Miscellaneous databases

EvolutionaryTracei Q9X255.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. "Structure of a NAD kinase from Thermotoga maritima at 2.3 A resolution."
    Oganesyan V., Huang C., Adams P.D., Jancarik J., Yokota H.A., Kim R., Kim S.H.
    Acta Crystallogr. F 61:640-646(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiNADK_THEMA
AccessioniPrimary (citable) accession number: Q9X255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3