Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9X255 (NADK_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:NADK
Ordered Locus Names:TM_1733
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subunit structure

Homodimer. Ref.2

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258NAD kinase HAMAP-Rule MF_00361
PRO_0000120680

Regions

Nucleotide binding51 – 522NAD By similarity
Nucleotide binding119 – 1202NAD By similarity
Nucleotide binding160 – 1656NAD By similarity

Sites

Active site511Proton acceptor By similarity
Binding site1301NAD By similarity
Binding site1491NAD By similarity
Binding site1841NAD; via carbonyl oxygen By similarity

Secondary structure

...................................... 258
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9X255 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 45EBBCA0B6FD3EAB

FASTA25829,242
        10         20         30         40         50         60 
MKIAILYREE REKEGEFLKE KISKEHEVIE FGEANAPGRV TADLIVVVGG DGTVLKAAKK 

        70         80         90        100        110        120 
AADGTPMVGF KAGRLGFLTS YTLDEIDRFL EDLRNWNFRE ETRWFIQIES ELGNHLALND 

       130        140        150        160        170        180 
VTLERDLSGK MVEIEVEVEH HSSMWFFADG VVISTPTGST AYSLSIGGPI IFPECEVLEI 

       190        200        210        220        230        240 
SPIAPQFFLT RSVVIPSNFK VVVESQRDIN MLVDGVLTGK TKRIEVKKSR RYVRILRPPE 

       250 
YDYVTVIRDK LGYGRRIE 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD36798.1.
PIRD72217.
RefSeqNP_229531.1. NC_000853.1.
YP_007978090.1. NC_021214.1.
YP_008991173.1. NC_023151.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YT5X-ray2.30A/B/C/D1-258[»]
ProteinModelPortalQ9X255.
SMRQ9X255. Positions 1-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM1733.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36798; AAD36798; TM_1733.
GeneID897872.
KEGGtma:TM1733.
tmi:THEMA_05570.
tmm:Tmari_1741.
PATRIC23938442. VBITheMar51294_1751.

Phylogenomic databases

eggNOGCOG0061.
KOK00858.
OMAHPSIPGW.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BRENDA2.7.1.23. 6331.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9X255.

Entry information

Entry nameNADK_THEMA
AccessionPrimary (citable) accession number: Q9X255
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references