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Q9X248 (FABG_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:TM_1724
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2462463-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054693

Regions

Nucleotide binding62 – 632NADP By similarity
Nucleotide binding154 – 1585NADP By similarity

Sites

Active site1541Proton acceptor By similarity
Binding site891NADP; via carbonyl oxygen By similarity
Binding site1411Substrate By similarity
Binding site1871NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9X248 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8C08904D28099142

FASTA24626,402
        10         20         30         40         50         60 
MRLEGKVCLI TGAASGIGKA TTLLFAQEGA TVIAGDISKE NLDSLVKEAE GLPGKVDPYV 

        70         80         90        100        110        120 
LNVTDRDQIK EVVEKVVQKY GRIDVLVNNA GITRDALLVR MKEEDWDAVI NVNLKGVFNV 

       130        140        150        160        170        180 
TQMVVPYMIK QRNGSIVNVS SVVGIYGNPG QTNYAASKAG VIGMTKTWAK ELAGRNIRVN 

       190        200        210        220        230        240 
AVAPGFIETP MTEKLPEKAR ETALSRIPLG RFGKPEEVAQ VILFLASDES SYVTGQVIGI 


DGGLVI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD36790.1.
PIRH72219.
RefSeqNP_229523.1. NC_000853.1.
YP_007978081.1. NC_021214.1.
YP_008991183.1. NC_023151.1.

3D structure databases

ProteinModelPortalQ9X248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM1724.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36790; AAD36790; TM_1724.
GeneID15495334.
18092974.
897230.
KEGGtma:TM1724.
tmm:Tmari_1732.
PATRIC23938424. VBITheMar51294_1742.

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMATDMTHGL.
OrthoDBEOG6N3CR8.
ProtClustDBCLSK875935.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_THEMA
AccessionPrimary (citable) accession number: Q9X248
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways