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Protein

Putative ribosome biogenesis GTPase RsgA

Gene

rsgA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover.UniRule annotation

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi250ZincUniRule annotation1 Publication1
Metal bindingi255ZincUniRule annotation1 Publication1
Metal bindingi257ZincUniRule annotation1 Publication1
Metal bindingi263ZincUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi117 – 120GTPUniRule annotation1 Publication4
Nucleotide bindingi170 – 178GTPUniRule annotation1 Publication9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribosome biogenesis GTPase RsgAUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:rsgAUniRule annotation
Synonyms:yjeQ
Ordered Locus Names:TM_1717
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715361 – 295Putative ribosome biogenesis GTPase RsgAAdd BLAST295

Interactioni

Subunit structurei

Monomer. Associates with ribosomes.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi243274.TM1717.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Beta strandi16 – 21Combined sources6
Turni22 – 24Combined sources3
Beta strandi27 – 32Combined sources6
Helixi34 – 36Combined sources3
Turni37 – 40Combined sources4
Beta strandi48 – 52Combined sources5
Beta strandi56 – 64Combined sources9
Turni72 – 75Combined sources4
Beta strandi76 – 78Combined sources3
Beta strandi81 – 86Combined sources6
Helixi95 – 107Combined sources13
Beta strandi111 – 116Combined sources6
Helixi119 – 121Combined sources3
Helixi124 – 137Combined sources14
Turni138 – 140Combined sources3
Beta strandi143 – 145Combined sources3
Turni148 – 150Combined sources3
Helixi154 – 161Combined sources8
Beta strandi162 – 169Combined sources8
Helixi176 – 183Combined sources8
Beta strandi210 – 212Combined sources3
Beta strandi218 – 222Combined sources5
Helixi235 – 238Combined sources4
Helixi239 – 241Combined sources3
Beta strandi245 – 247Combined sources3
Beta strandi257 – 259Combined sources3
Helixi264 – 271Combined sources8
Helixi276 – 290Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U0LX-ray2.80A/B/C1-295[»]
ProteinModelPortaliQ9X242.
SMRiQ9X242.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 228CP-type GPROSITE-ProRule annotationAdd BLAST161

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi250 – 263Knuckle-like cysteine clusterUniRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.UniRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
InParanoidiQ9X242.
KOiK06949.
OMAiTHIIAAN.

Family and domain databases

CDDicd01854. YjeQ_EngC. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
IPR031944. RsgA_N.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
PF16745. RsgA_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRRRGIVV SFHSNMVTVE DEETGERILC KLRGKFRLQN LKIYVGDRVE
60 70 80 90 100
YTPDETGSGV IENVLHRKNL LTKPHVANVD QVILVVTVKM PETSTYIIDK
110 120 130 140 150
FLVLAEKNEL ETVMVINKMD LYDEDDLRKV RELEEIYSGL YPIVKTSAKT
160 170 180 190 200
GMGIEELKEY LKGKISTMAG LSGVGKSSLL NAINPGLKLR VSEVSEKLQR
210 220 230 240 250
GRHTTTTAQL LKFDFGGYVV DTPGFANLEI NDIEPEELKH YFKEFGDKQC
260 270 280 290
FFSDCNHVDE PECGVKEAVE NGEIAESRYE NYVKMFYELL GRRKK
Length:295
Mass (Da):33,642
Last modified:November 1, 1999 - v1
Checksum:iE8A9E7396C855848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36783.1.
PIRiA72219.
RefSeqiNP_229516.1. NC_000853.1.
WP_010865389.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD36783; AAD36783; TM_1717.
GeneIDi897880.
KEGGitma:TM1717.
tmi:THEMA_05655.
PATRICi23938410. VBITheMar51294_1735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36783.1.
PIRiA72219.
RefSeqiNP_229516.1. NC_000853.1.
WP_010865389.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U0LX-ray2.80A/B/C1-295[»]
ProteinModelPortaliQ9X242.
SMRiQ9X242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36783; AAD36783; TM_1717.
GeneIDi897880.
KEGGitma:TM1717.
tmi:THEMA_05655.
PATRICi23938410. VBITheMar51294_1735.

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
InParanoidiQ9X242.
KOiK06949.
OMAiTHIIAAN.

Miscellaneous databases

EvolutionaryTraceiQ9X242.

Family and domain databases

CDDicd01854. YjeQ_EngC. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
IPR031944. RsgA_N.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
PF16745. RsgA_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSGA_THEMA
AccessioniPrimary (citable) accession number: Q9X242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.