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Protein

Putative ribosome biogenesis GTPase RsgA

Gene

rsgA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover.UniRule annotation

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi250 – 2501ZincUniRule annotation1 Publication
Metal bindingi255 – 2551ZincUniRule annotation1 Publication
Metal bindingi257 – 2571ZincUniRule annotation1 Publication
Metal bindingi263 – 2631ZincUniRule annotation1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi117 – 1204GTPUniRule annotation1 Publication
Nucleotide bindingi170 – 1789GTPUniRule annotation1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribosome biogenesis GTPase RsgAUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:rsgAUniRule annotation
Synonyms:yjeQ
Ordered Locus Names:TM_1717
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Putative ribosome biogenesis GTPase RsgAPRO_0000171536Add
BLAST

Interactioni

Subunit structurei

Monomer. Associates with ribosomes.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi243274.TM1717.

Structurei

Secondary structure

1
295
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 139Combined sources
Beta strandi16 – 216Combined sources
Turni22 – 243Combined sources
Beta strandi27 – 326Combined sources
Helixi34 – 363Combined sources
Turni37 – 404Combined sources
Beta strandi48 – 525Combined sources
Beta strandi56 – 649Combined sources
Turni72 – 754Combined sources
Beta strandi76 – 783Combined sources
Beta strandi81 – 866Combined sources
Helixi95 – 10713Combined sources
Beta strandi111 – 1166Combined sources
Helixi119 – 1213Combined sources
Helixi124 – 13714Combined sources
Turni138 – 1403Combined sources
Beta strandi143 – 1453Combined sources
Turni148 – 1503Combined sources
Helixi154 – 1618Combined sources
Beta strandi162 – 1698Combined sources
Helixi176 – 1838Combined sources
Beta strandi210 – 2123Combined sources
Beta strandi218 – 2225Combined sources
Helixi235 – 2384Combined sources
Helixi239 – 2413Combined sources
Beta strandi245 – 2473Combined sources
Beta strandi257 – 2593Combined sources
Helixi264 – 2718Combined sources
Helixi276 – 29015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U0LX-ray2.80A/B/C1-295[»]
ProteinModelPortaliQ9X242.
SMRiQ9X242. Positions 3-293.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 228161CP-type GPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi250 – 26314Knuckle-like cysteine clusterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.UniRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
InParanoidiQ9X242.
KOiK06949.
OMAiPIICITK.
OrthoDBiEOG69SKDD.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA.
InterProiIPR030378. G_CP_dom.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
IPR031944. RsgA_N.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
PF16745. RsgA_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRRRGIVV SFHSNMVTVE DEETGERILC KLRGKFRLQN LKIYVGDRVE
60 70 80 90 100
YTPDETGSGV IENVLHRKNL LTKPHVANVD QVILVVTVKM PETSTYIIDK
110 120 130 140 150
FLVLAEKNEL ETVMVINKMD LYDEDDLRKV RELEEIYSGL YPIVKTSAKT
160 170 180 190 200
GMGIEELKEY LKGKISTMAG LSGVGKSSLL NAINPGLKLR VSEVSEKLQR
210 220 230 240 250
GRHTTTTAQL LKFDFGGYVV DTPGFANLEI NDIEPEELKH YFKEFGDKQC
260 270 280 290
FFSDCNHVDE PECGVKEAVE NGEIAESRYE NYVKMFYELL GRRKK
Length:295
Mass (Da):33,642
Last modified:November 1, 1999 - v1
Checksum:iE8A9E7396C855848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36783.1.
PIRiA72219.
RefSeqiNP_229516.1. NC_000853.1.
WP_010865389.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD36783; AAD36783; TM_1717.
GeneIDi897880.
KEGGitma:TM1717.
tmi:THEMA_05655.
PATRICi23938410. VBITheMar51294_1735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36783.1.
PIRiA72219.
RefSeqiNP_229516.1. NC_000853.1.
WP_010865389.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U0LX-ray2.80A/B/C1-295[»]
ProteinModelPortaliQ9X242.
SMRiQ9X242. Positions 3-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36783; AAD36783; TM_1717.
GeneIDi897880.
KEGGitma:TM1717.
tmi:THEMA_05655.
PATRICi23938410. VBITheMar51294_1735.

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
InParanoidiQ9X242.
KOiK06949.
OMAiPIICITK.
OrthoDBiEOG69SKDD.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1765-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9X242.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA.
InterProiIPR030378. G_CP_dom.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
IPR031944. RsgA_N.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
PF16745. RsgA_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. "Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain."
    Shin D.H., Lou Y., Jancarik J., Yokota H., Kim R., Kim S.-H.
    Proc. Natl. Acad. Sci. U.S.A. 101:13198-13203(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH GDP AND ZINC IONS, PROBABLE SUBUNIT.
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiRSGA_THEMA
AccessioniPrimary (citable) accession number: Q9X242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.