Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.

Cofactori

FADBy similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531By similarity
Active sitei203 – 2031Proton donorBy similarity
Active sitei274 – 2741By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1762-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:TM_1714
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284UDP-N-acetylenolpyruvoylglucosamine reductasePRO_0000179280Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1714.

Structurei

3D structure databases

ProteinModelPortaliQ9X239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 174163FAD-binding PCMH-typeAdd
BLAST

Sequence similaritiesi

Belongs to the MurB family.Curated
Contains 1 FAD-binding PCMH-type domain.Curated

Phylogenomic databases

eggNOGiENOG4105D4A. Bacteria.
COG0812. LUCA.
InParanoidiQ9X239.
KOiK00075.
OMAiLAPLTWF.
OrthoDBiEOG60CWQ3.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKLSCHTS IKIGGRVKYL VLPNDVFSLE RAITVLKDLP FQIMGLGTNL
60 70 80 90 100
LVQDEDLDIA VLKTERLNQI EIKGEKVLVE SGTPLKRLCL FLMEAELGGL
110 120 130 140 150
EFAYGIPGSV GGAIYMNAGA YGGEIGEFVE AVEVLRDGEK TWLSRNEIFF
160 170 180 190 200
GYRDSTFKRE KLIITRVMMS FKKEKKETIK AKMDDYMRRR LEKQPLDLPS
210 220 230 240 250
AGSVFKRPRE DFYVGKAIES LGLKGYRIGG AQISEKHAGF IVNAGSATFD
260 270 280
DVMKLIDFVR KKVKEKYGVE LETEVEIWWN GRRW
Length:284
Mass (Da):32,253
Last modified:November 1, 1999 - v1
Checksum:i689D0DA9475A30DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36780.1.
PIRiC72222.
RefSeqiNP_229513.1. NC_000853.1.
WP_010865388.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD36780; AAD36780; TM_1714.
GeneIDi897266.
KEGGitma:TM1714.
tmi:THEMA_05670.
PATRICi23938404. VBITheMar51294_1732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36780.1.
PIRiC72222.
RefSeqiNP_229513.1. NC_000853.1.
WP_010865388.1. NC_000853.1.

3D structure databases

ProteinModelPortaliQ9X239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36780; AAD36780; TM_1714.
GeneIDi897266.
KEGGitma:TM1714.
tmi:THEMA_05670.
PATRICi23938404. VBITheMar51294_1732.

Phylogenomic databases

eggNOGiENOG4105D4A. Bacteria.
COG0812. LUCA.
InParanoidiQ9X239.
KOiK00075.
OMAiLAPLTWF.
OrthoDBiEOG60CWQ3.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciTMAR243274:GC6P-1762-MONOMER.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiMURB_THEMA
AccessioniPrimary (citable) accession number: Q9X239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 11, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.