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Q9X215

- KGUA_THEMA

UniProt

Q9X215 - KGUA_THEMA

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Protein

Guanylate kinase

Gene

gmk

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:TM_1689
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Guanylate kinasePRO_0000170630Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1689.

Structurei

3D structure databases

ProteinModelPortaliQ9X215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 181179Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated
Contains 1 guanylate kinase-like domain.Curated

Phylogenomic databases

eggNOGiCOG0194.
InParanoidiQ9X215.
KOiK00942.
OMAiMSHYNEY.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR003593. AAA+_ATPase.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X215-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGQLFVICG PSGAGKTSII KEVLKRLDNV VFSVSCTTRP KRPHEEDGKD
60 70 80 90 100
YFFITEEEFL KRVERGEFLE WARVHGHLYG TLRSFVESHI NEGKDVVLDI
110 120 130 140 150
DVQGALSVKK KYSNTVFIYV APPSYADLRE RILKRGTEKE ADVLVRLENA
160 170 180 190 200
KWELMFMDEF DYIVVNENLE DAVEMVVSIV RSERAKVTRN QDKIERFKME

VKGWKKL
Length:207
Mass (Da):24,037
Last modified:November 1, 1999 - v1
Checksum:iE38375CFF2E26963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36756.1.
PIRiC72223.
RefSeqiNP_229489.1. NC_000853.1.
WP_004082205.1. NC_023151.1.
YP_007978046.1. NC_021214.1.
YP_008991218.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36756; AAD36756; TM_1689.
GeneIDi18093009.
897895.
KEGGitma:TM1689.
PATRICi23938352. VBITheMar51294_1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36756.1 .
PIRi C72223.
RefSeqi NP_229489.1. NC_000853.1.
WP_004082205.1. NC_023151.1.
YP_007978046.1. NC_021214.1.
YP_008991218.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9X215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1689.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36756 ; AAD36756 ; TM_1689 .
GeneIDi 18093009.
897895.
KEGGi tma:TM1689.
PATRICi 23938352. VBITheMar51294_1706.

Phylogenomic databases

eggNOGi COG0194.
InParanoidi Q9X215.
KOi K00942.
OMAi MSHYNEY.
OrthoDBi EOG6CP410.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR003593. AAA+_ATPase.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiKGUA_THEMA
AccessioniPrimary (citable) accession number: Q9X215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3