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Q9X215 (KGUA_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:TM_1689
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Guanylate kinase HAMAP-Rule MF_00328
PRO_0000170630

Regions

Domain3 – 181179Guanylate kinase-like
Nucleotide binding10 – 178ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9X215 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: E38375CFF2E26963

FASTA20724,037
        10         20         30         40         50         60 
MKGQLFVICG PSGAGKTSII KEVLKRLDNV VFSVSCTTRP KRPHEEDGKD YFFITEEEFL 

        70         80         90        100        110        120 
KRVERGEFLE WARVHGHLYG TLRSFVESHI NEGKDVVLDI DVQGALSVKK KYSNTVFIYV 

       130        140        150        160        170        180 
APPSYADLRE RILKRGTEKE ADVLVRLENA KWELMFMDEF DYIVVNENLE DAVEMVVSIV 

       190        200 
RSERAKVTRN QDKIERFKME VKGWKKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD36756.1.
PIRC72223.
RefSeqNP_229489.1. NC_000853.1.
YP_007978046.1. NC_021214.1.
YP_008991218.1. NC_023151.1.

3D structure databases

ProteinModelPortalQ9X215.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM1689.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36756; AAD36756; TM_1689.
GeneID897895.
KEGGtma:TM1689.
tmi:THEMA_05795.
tmm:Tmari_1697.
PATRIC23938352. VBITheMar51294_1706.

Phylogenomic databases

eggNOGCOG0194.
KOK00942.
OMAMSHYNEY.
OrthoDBEOG6CP410.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR003593. AAA+_ATPase.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_THEMA
AccessionPrimary (citable) accession number: Q9X215
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families