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Protein

Alkyl hydroperoxide reductase AhpD

Gene

TM_1620

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.SAAS annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

AntioxidantSAAS annotation, LyaseImported, Oxidoreductase, PeroxidaseSAAS annotation

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1666-MONOMER.

Protein family/group databases

PeroxiBasei4560. TmaCMD.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpDSAAS annotation (EC:1.11.1.15SAAS annotation)
Gene namesi
Ordered Locus Names:TM_1620Imported
ORF Names:Tmari_1629Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000013901 Componenti: Chromosome
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 62Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1620.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P8CX-ray2.30A/B/C/D/E/F1-121[»]
1VKEX-ray1.56A/B/C/D/E/F1-121[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10277CMDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AhpD family.SAAS annotation

Keywords - Domaini

Redox-active centerSAAS annotation

Phylogenomic databases

eggNOGiENOG4107YV4. Bacteria.
COG0599. LUCA.
OMAiRIFNLDT.
OrthoDBiEOG6X3W8C.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X1V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYKKFVEAR RELNEKVLSR GTLNTKRFFN LDSAVYRPGK LDVKTKELMG
60 70 80 90 100
LVASTVLRCD DCIRYHLVRC VQEGASDEEI FEALDIALVV GGSIVIPHLR
110 120
RAVGFLEELR EMEKNGETIS L
Length:121
Mass (Da):13,789
Last modified:November 1, 1999 - v1
Checksum:i256A16A2F49A4548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36687.1.
CP004077 Genomic DNA. Translation: AGL50553.1.
PIRiF72232.
RefSeqiNP_229420.1. NC_000853.1.
WP_004082088.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36687; AAD36687; TM_1620.
AGL50553; AGL50553; Tmari_1629.
GeneIDi897931.
KEGGitma:TM1620.
tmi:THEMA_06145.
tmm:Tmari_1629.
tmw:THMA_1661.
PATRICi23938214. VBITheMar51294_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36687.1.
CP004077 Genomic DNA. Translation: AGL50553.1.
PIRiF72232.
RefSeqiNP_229420.1. NC_000853.1.
WP_004082088.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P8CX-ray2.30A/B/C/D/E/F1-121[»]
1VKEX-ray1.56A/B/C/D/E/F1-121[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1620.

Protein family/group databases

PeroxiBasei4560. TmaCMD.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36687; AAD36687; TM_1620.
AGL50553; AGL50553; Tmari_1629.
GeneIDi897931.
KEGGitma:TM1620.
tmi:THEMA_06145.
tmm:Tmari_1629.
tmw:THMA_1661.
PATRICi23938214. VBITheMar51294_1639.

Phylogenomic databases

eggNOGiENOG4107YV4. Bacteria.
COG0599. LUCA.
OMAiRIFNLDT.
OrthoDBiEOG6X3W8C.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1666-MONOMER.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
  2. "Crystal Structure Analysis of Thermotoga maritima protein TM1620 (APC4843)."
    Kim Y., Joachimiak A., Brunzelle J.S., Korolev S.V., Edwards A., Xu X., Savchenko A.
    Submitted (MAY-2003) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS), DISULFIDE BONDS.
  3. "Crystal structure of carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response (TM1620) from Thermotoga maritima at 1.56 A resolution."
    Joint Center for Structural Genomics (JCSG)
    Submitted (MAY-2004) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS), DISULFIDE BONDS.
  4. "The genome organization of Thermotoga maritima reflects its lifestyle."
    Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
    PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.

Entry informationi

Entry nameiQ9X1V5_THEMA
AccessioniPrimary (citable) accession number: Q9X1V5
Secondary accession number(s): G4FG09
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.